I/UCRC: Characterization and Bioengineering of Optogenetic Rhodopsins
I/UCRC:光遗传学视紫红质的表征和生物工程
基本信息
- 批准号:1230851
- 负责人:
- 金额:$ 20万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-07-01 至 2013-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Program Director's Recommendation Center for Biophotonic Sensors and Systems (CBSS) Proposal # 1230851 Thomas Bifano This proposal seeks funding for the Center forBiophotonic Sensors and Systems located at Boston University. Funding Requests for Fundamental Research are authorized by an NSF approved solicitation, NSF 11-570. The solicitation invites I/UCRCs to submit proposals for support of industry-defined fundamental research. Recent developments in membrane biophysics, neurophysiology and molecular biology have provided the catalyst for the birth of a new field termed "optogenetics". Optogenetics relies on the expression of several unusual microbial rhodopsins in the neuronal membrane including channelrhodopsin (ChR) for light activating nerves and Archaerhodopsin (AR3) for light silencing nerves. There is a need to understand the molecular mechanisms of these proteins followed by bottoms-up bioengineering to circumvent current limitations. This project will focus on application of a set of powerful spectroscopic and biomolecular engineering techniques developed at Boston University (BU) and UC Davis. The project involves close collaboration with several industry partners and a team of leading experts in optogenetics and rhodopsins from BU, UC Davis, MIT, Harvard and the University of Texas. Impact of the proposed project includes potentially transformative approaches to study brain function, treatment for brain disorders and restoring vision for retinal degenerative diseases. The deliverables from this project are: (1) Improved versions of ChR and AR3 with red-shifted visible absorbance, improved dynamics and improved voltage response, and (2) Document product requirements for optogenetic research tools and product vision. The industry support of the I/UCRC and active participation in this research program enhances the graduate educational experience by providing a pipeline for talented engineers and scientist to industry. BU's commitment to develop the academic potential of underrepresented groups in STEM fields will be further enhanced by offering industrial career options, informal mentorships and internships with the I/UCRC partners.
项目主任推荐生物光子传感器和系统中心 (CBSS) 提案#1230851 Thomas Bifano 该提案为位于波士顿大学的生物光子传感器和系统中心寻求资金。基础研究的资助申请由 NSF 批准的征集 NSF 11-570 授权。此次征集邀请 I/UCRC 提交支持行业定义的基础研究的提案。膜生物物理学、神经生理学和分子生物学的最新发展为“光遗传学”这一新领域的诞生提供了催化剂。光遗传学依赖于神经元膜中几种不寻常的微生物视紫红质的表达,包括用于光激活神经的通道视紫红质(ChR)和用于光沉默神经的古视紫红质(AR3)。需要了解这些蛋白质的分子机制,然后进行自下而上的生物工程来规避当前的限制。该项目将重点应用波士顿大学 (BU) 和加州大学戴维斯分校开发的一套强大的光谱和生物分子工程技术。该项目涉及多个行业合作伙伴以及来自波士顿大学、加州大学戴维斯分校、麻省理工学院、哈佛大学和德克萨斯大学的光遗传学和视紫红质领先专家团队的密切合作。拟议项目的影响包括研究大脑功能、治疗大脑疾病和恢复视网膜退行性疾病视力的潜在变革方法。该项目的可交付成果是:(1) ChR 和 AR3 的改进版本,具有红移可见光吸光度、改进的动力学和改进的电压响应,以及 (2) 记录光遗传学研究工具和产品愿景的产品要求。 I/UCRC 的行业支持以及对该研究项目的积极参与,为有才华的工程师和科学家进入行业提供了渠道,从而增强了研究生教育体验。通过提供工业职业选择、非正式指导和与 I/UCRC 合作伙伴的实习,BU 将进一步加强对开发 STEM 领域代表性不足群体的学术潜力的承诺。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Thomas Bifano其他文献
Thomas Bifano的其他文献
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{{ truncateString('Thomas Bifano', 18)}}的其他基金
MRI: Acquisition of a Spinning Disk Confocal Super-resolution Microscope for Transcriptomics Research at Boston University
MRI:波士顿大学购买用于转录组学研究的转盘共焦超分辨率显微镜
- 批准号:
2215990 - 财政年份:2022
- 资助金额:
$ 20万 - 项目类别:
Standard Grant
Phase II I/UCRC Trustees of Boston University: Center on Biophotonic Sensors and Systems
波士顿大学 II 期 I/UCRC 受托人:生物光子传感器和系统中心
- 批准号:
1650504 - 财政年份:2017
- 资助金额:
$ 20万 - 项目类别:
Continuing Grant
2014 Workshop on Noninvasive Brain Imaging
2014年无创脑成像研讨会
- 批准号:
1445762 - 财政年份:2014
- 资助金额:
$ 20万 - 项目类别:
Standard Grant
MRI: Development of a Holographic Nanoscale Optics Instrument
MRI:全息纳米级光学仪器的开发
- 批准号:
1429437 - 财政年份:2014
- 资助金额:
$ 20万 - 项目类别:
Standard Grant
PFI-AIR: Nanoplasmonic Metamaterial Antennae for Efficient Wireless Power Transmission
PFI-AIR:用于高效无线电力传输的纳米等离子体超材料天线
- 批准号:
1237848 - 财政年份:2012
- 资助金额:
$ 20万 - 项目类别:
Standard Grant
IUCRC Collaborative Research: I/UCRC: Center for Biophotonic Sensors and Systems (CBSS)
IUCRC 合作研究:I/UCRC:生物光子传感器和系统中心 (CBSS)
- 批准号:
1068070 - 财政年份:2011
- 资助金额:
$ 20万 - 项目类别:
Continuing Grant
Scalable, cost-effective, high-actuator-count deformable mirrors for astronomical adaptive optics
用于天文自适应光学的可扩展、经济高效、高执行器数量的可变形镜
- 批准号:
1105615 - 财政年份:2011
- 资助金额:
$ 20万 - 项目类别:
Continuing Grant
TRIPSS - RET Site in Biophotonics Sensors and Systems
TRIPSS - 生物光子学传感器和系统中的 RET 站点
- 批准号:
1009808 - 财政年份:2010
- 资助金额:
$ 20万 - 项目类别:
Continuing Grant
Collaborative Research: Center for Biophotonic Sensors and Systems
合作研究:生物光子传感器和系统中心
- 批准号:
0855971 - 财政年份:2009
- 资助金额:
$ 20万 - 项目类别:
Standard Grant
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