Phase II I/UCRC Trustees of Boston University: Center on Biophotonic Sensors and Systems

波士顿大学 II 期 I/UCRC 受托人：生物光子传感器和系统中心

• 批准号: 1650504
• 负责人: Thomas Bifano
• 金额: $ 50万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1650504&HistoricalAwards=false
• 关键词: Phase; II; UCRC; Trustees; Boston

CBSS operates at the intersection of life sciences and photonics engineering and focuses on precompetitive research that provides the enabling technologies for advanced methods to detect, sense and identify biological properties, conditions or changes at the molecular, cellular and subcellular level. These innovations will address solutions in the areas of Disease Diagnosis, Drug Efficacy Testing & Monitoring, Drug Discovery, and Food & Water Safety through long-term partnerships with industry members. During Phase II, research efforts will continue at Boston University (lead institution) and UC Davis (university site) to develop collaborations with faculty across our campuses whose research is relevant to the Center?s mission. BU?s Creating the Societal Engineer, a concept of a social consciousness and appreciation for how products advance our quality of life while creating jobs and economic opportunity, resonates well with a primary mission of the Center to educate a diverse pipeline of trained scientist and engineers. Students have an opportunity to directly participate in the technology transfer process and with industry learn to identify applications and define areas of greatest needs, evaluate new technologies and research tools, and pursue research that can be applied to solving real-world challenges and improving healthcare outcomes. As CBSS grows, the Center intends to capitalize on a trend by companies in the life sciences sector to accelerate innovation through collaborative research and university-led innovations, specifically in the area of biophotonic sensing. The Center's value to the membership is based on the ability to deliver pre-competitive research that can be adapted to align with a member?s product portfolio plans. This high priority research and product directed research typically remains the focus of each individual company, but collectively, the membership values the Center for:- Adding to the breadth and diversity of a member's research portfolio.- Working on pre-competitive technologies that could add some benefits in the future.- Working on alternative approaches that have merit but which a member company has neither, the time or resources to pursue. This also helps a member better position their existing product/technology approaches.- Providing exposure to emerging areas of research that may be outside the company?s domain, thus adding to a member?s innovation capability.The research projects, guided by industry strategic oversight, will lead to breakthroughs in understanding cell/host interactions, new biomarker discovery, point-of-care and interoperation diagnostics, personalized cancer treatment, and many other technologies that will improve the quality of healthcare. The Center?s research is aligned with three overlapping thrust areas: Bio-Imaging, Optical Diagnostics and Analytics, and each of these thrust areas has a component in Systems, Sensors & Devices, and Materials & Biology. The goal of the Analytics research is to embed data retrieval and computing processing power in imaging and diagnostic tools to develop an understanding of biological, genetic, behavioral and environmental data gathered so that healthcare decisions can be made down to the individual level. At BU recent developments in high-resolution tip-tilt-position deformable mirrors (TPP-DM) combined with computation and machine learning algorithms demonstrate the combinations of bio-imaging and analytics for applications such as imaging of blood and tissue samples or cell sorting.

CBSS在生命科学和光子学工程的交汇处进行操作，并专注于预竞争性研究，该研究为高级方法提供了能力技术，以检测，感知和识别分子，细胞和亚细胞水平的生物学特性，条件或变化。 这些创新将通过与行业成员的长期合作伙伴关系来解决疾病诊断，药物疗效测试，药物发现以及食品和水安全领域的解决方案。在第二阶段期间，研究工作将继续在波士顿大学（领导机构）和加州大学戴维斯分校（UC Davis）（大学站点）继续进行，以在我们的校园中与研究中心的任务相关的校园中与教师进行合作。 建立社会工程师，这是一种社会意识和对产品如何提高我们的生活质量和创造就业机会和经济机会的概念的概念，这与中心的主要使命令人着迷，以教育多样化的受过训练的科学家和工程师。 学生有机会直接参与技术转移流程，并随着行业学习确定应用程序并定义最大需求的领域，评估新技术和研究工具，并从事可以应用于解决现实世界中的挑战和改善医疗保健结果的研究。随着CBS的发展，该中心打算利用生命科学领域的公司通过协作研究和大学主导的创新来加速创新的趋势，特别是在生物光传感领域。该中心对会员资格的价值是基于提供竞争性研究的能力，该研究可以适应与会员的产品组合计划相一致的能力。这项高优先研究和产品的指示研究通常仍然是每个公司的重点，但总的来说，成员重视以下中心： - 增加会员研究组合的广度和多样性。 This also helps a member better position their existing product/technology approaches.- Providing exposure to emerging areas of research that may be outside the company?s domain, thus adding to a member?s innovation capability.The research projects, guided by industry strategic oversight, will lead to breakthroughs in understanding cell/host interactions, new biomarker discovery, point-of-care and interoperation diagnostics, personalized cancer treatment, and many other technologies that will improve the quality of 卫生保健。该中心的研究与三个重叠的推力区域保持一致：生物成像，光学诊断和分析，并且这些推力区域中的每一个都具有系统，传感器和设备以及材料与生物学的组成部分。分析研究的目的是将数据检索和计算处理能力嵌入成像和诊断工具中，以发展对收集的生物学，遗传，行为和环境数据的理解，以便可以将医疗保健决策降低到个人水平。 在BU最新的发展中，高分辨率倾斜位置可变形镜（TPP-DM）与计算和机器学习算法相结合，证明了生物形象和分析的组合，用于应用诸如血液和组织样品或细胞分类的应用。

项目成果

Extended depth-of-field microscopy with a high-speed deformable mirror

• DOI: 10.1364/ol.42.000995
• 发表时间: 2017-03-01
• 期刊: OPTICS LETTERS
• 影响因子: 3.6
• 作者: Shain, William J.;Vickers, Nicholas A.;Mertz, Jerome
• 通讯作者: Mertz, Jerome

Protective Effect of Intravitreal Administration of Exosomes Derived from Mesenchymal Stem Cells on Retinal Ischemia.

• DOI: 10.1080/02713683.2017.1319491
• 发表时间: 2017-10
• 期刊: Current eye research
• 影响因子: 2
• 作者: Moisseiev E;Anderson JD;Oltjen S;Goswami M;Zawadzki RJ;Nolta JA;Park SS
• 通讯作者: Park SS

Dual fluorescence-absorption deconvolution applied to extended-depth-of-field microscopy

双荧光吸收解卷积应用于扩展景深显微镜

• DOI: 10.1364/ol.42.004183
• 发表时间: 2017
• 期刊: Optics Letters
• 影响因子: 3.6
• 作者: Shain, William J.;Vickers, Nicholas A.;Negash, Awoke;Bifano, Thomas;Sentenac, Anne;Mertz, Jerome
• 通讯作者: Mertz, Jerome