Phase II I/UCRC Trustees of Boston University: Center on Biophotonic Sensors and Systems

波士顿大学 II 期 I/UCRC 受托人：生物光子传感器和系统中心

• 批准号: 1650504
• 负责人: Thomas Bifano
• 金额: $ 50万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1650504&HistoricalAwards=false
• 关键词: Phase; II; UCRC; Trustees; Boston

CBSS operates at the intersection of life sciences and photonics engineering and focuses on precompetitive research that provides the enabling technologies for advanced methods to detect, sense and identify biological properties, conditions or changes at the molecular, cellular and subcellular level. These innovations will address solutions in the areas of Disease Diagnosis, Drug Efficacy Testing & Monitoring, Drug Discovery, and Food & Water Safety through long-term partnerships with industry members. During Phase II, research efforts will continue at Boston University (lead institution) and UC Davis (university site) to develop collaborations with faculty across our campuses whose research is relevant to the Center?s mission. BU?s Creating the Societal Engineer, a concept of a social consciousness and appreciation for how products advance our quality of life while creating jobs and economic opportunity, resonates well with a primary mission of the Center to educate a diverse pipeline of trained scientist and engineers. Students have an opportunity to directly participate in the technology transfer process and with industry learn to identify applications and define areas of greatest needs, evaluate new technologies and research tools, and pursue research that can be applied to solving real-world challenges and improving healthcare outcomes. As CBSS grows, the Center intends to capitalize on a trend by companies in the life sciences sector to accelerate innovation through collaborative research and university-led innovations, specifically in the area of biophotonic sensing. The Center's value to the membership is based on the ability to deliver pre-competitive research that can be adapted to align with a member?s product portfolio plans. This high priority research and product directed research typically remains the focus of each individual company, but collectively, the membership values the Center for:- Adding to the breadth and diversity of a member's research portfolio.- Working on pre-competitive technologies that could add some benefits in the future.- Working on alternative approaches that have merit but which a member company has neither, the time or resources to pursue. This also helps a member better position their existing product/technology approaches.- Providing exposure to emerging areas of research that may be outside the company?s domain, thus adding to a member?s innovation capability.The research projects, guided by industry strategic oversight, will lead to breakthroughs in understanding cell/host interactions, new biomarker discovery, point-of-care and interoperation diagnostics, personalized cancer treatment, and many other technologies that will improve the quality of healthcare. The Center?s research is aligned with three overlapping thrust areas: Bio-Imaging, Optical Diagnostics and Analytics, and each of these thrust areas has a component in Systems, Sensors & Devices, and Materials & Biology. The goal of the Analytics research is to embed data retrieval and computing processing power in imaging and diagnostic tools to develop an understanding of biological, genetic, behavioral and environmental data gathered so that healthcare decisions can be made down to the individual level. At BU recent developments in high-resolution tip-tilt-position deformable mirrors (TPP-DM) combined with computation and machine learning algorithms demonstrate the combinations of bio-imaging and analytics for applications such as imaging of blood and tissue samples or cell sorting.

CBSS在生命科学和光子工程的交叉点上运作，专注于竞争前研究，为先进方法提供技术，以检测，感知和识别分子，细胞和亚细胞水平的生物特性，条件或变化。 这些创新将通过与行业成员的长期合作关系，解决疾病诊断、药物疗效测试监测、药物发现和食品水安全等领域的解决方案。在第二阶段，研究工作将继续在波士顿大学（牵头机构）和加州大学戴维斯分校（大学网站），以发展与教师在我们的校园，其研究是相关的中心合作？的使命。 布鲁里？创造社会工程师，一个社会意识的概念，并赞赏产品如何提高我们的生活质量，同时创造就业机会和经济机会，共鸣与该中心的主要使命，教育训练有素的科学家和工程师的多样化管道。 学生有机会直接参与技术转让过程，并与行业一起学习识别应用程序并定义最大需求的领域，评估新技术和研究工具，并进行可应用于解决现实世界挑战和改善医疗保健结果的研究。随着CBSS的发展，该中心打算利用生命科学领域公司的趋势，通过合作研究和大学主导的创新来加速创新，特别是在生物光子传感领域。中心对会员的价值是基于提供竞争前研究的能力，这些研究可以根据会员的需要进行调整。的产品组合计划。这种高优先级的研究和产品导向的研究通常仍然是每个公司的重点，但总的来说，会员重视中心：-增加成员研究组合的广度和多样性。致力于竞争前的技术，可以在未来增加一些好处。致力于有价值的替代方法，但成员公司既没有时间也没有资源去追求。 这也有助于成员更好地定位其现有的产品/技术方法。提供对可能在公司之外的新兴研究领域的接触？的域，从而添加到一个成员？在行业战略监督的指导下，这些研究项目将在理解细胞/宿主相互作用、新的生物标志物发现、即时和互操作诊断、个性化癌症治疗以及许多其他技术方面取得突破，这些技术将提高医疗保健质量。中心？的研究与三个重叠的推力领域：生物成像，光学诊断和分析，这些推力领域中的每一个都有系统，传感器设备和材料生物学的组成部分。分析研究的目标是在成像和诊断工具中嵌入数据检索和计算处理能力，以了解收集的生物，遗传，行为和环境数据，从而可以在个人层面做出医疗决策。 在BU，高分辨率倾斜位置可变形反射镜（TPP-DM）与计算和机器学习算法相结合的最新发展展示了生物成像和分析的组合，用于血液和组织样本成像或细胞分选等应用。

项目成果

Extended depth-of-field microscopy with a high-speed deformable mirror

• DOI: 10.1364/ol.42.000995
• 发表时间: 2017-03-01
• 期刊: OPTICS LETTERS
• 影响因子: 3.6
• 作者: Shain, William J.;Vickers, Nicholas A.;Mertz, Jerome
• 通讯作者: Mertz, Jerome

Protective Effect of Intravitreal Administration of Exosomes Derived from Mesenchymal Stem Cells on Retinal Ischemia.

• DOI: 10.1080/02713683.2017.1319491
• 发表时间: 2017-10
• 期刊: Current eye research
• 影响因子: 2
• 作者: Moisseiev E;Anderson JD;Oltjen S;Goswami M;Zawadzki RJ;Nolta JA;Park SS
• 通讯作者: Park SS

Dual fluorescence-absorption deconvolution applied to extended-depth-of-field microscopy

双荧光吸收解卷积应用于扩展景深显微镜

• DOI: 10.1364/ol.42.004183
• 发表时间: 2017
• 期刊: Optics Letters
• 影响因子: 3.6
• 作者: Shain, William J.;Vickers, Nicholas A.;Negash, Awoke;Bifano, Thomas;Sentenac, Anne;Mertz, Jerome
• 通讯作者: Mertz, Jerome