"PESO: Microfabricated surfaces for analysis of exosome-based paracrine signaling in hepatocellular carcinomas"

1233617/Revzin该奖项是通过国家科学基金会和国家癌症研究所之间的联合计划支持的。 癌症起源于组织和器官的微米级区域，称为癌症微环境。 这种微环境由健康细胞和癌细胞组成，这些细胞非常接近，并通过可溶性分子相互传递信号。 细胞信号传导或通信的研究很重要，因为它可以揭示为什么一些癌症保持休眠状态，而另一些则变得具有侵略性，从原发部位转移。 该基金的目标是研究癌症细胞间通讯的新机制。 这种机制是基于称为外泌体的脂质颗粒，由癌细胞分泌并在其中携带核酸和蛋白质的有效载荷。研究人员假设，邻近非癌细胞对外泌体的摄取可能会促进癌症的进展和转移。 这项工作的目标是开发用于检测外泌体产生的新型传感技术，以及用于评估外泌体产生癌细胞对邻近非癌细胞影响的新型细胞培养方法。 研究工作将集中在肝癌的研究上。

1233617/ RevzinThis award is supported through a joint program between the National Science Foundation and the National Cancer Institute. Cancers originate in micrometere scale regions of tissues and organs called cancer microenvironment. This microenvironment consists of healthy as well as cancerous cells that are present in close proximity and signal to each other via soluble molecules. The study of cell signaling or communication is important as it may reveal why some cancers remain dormant while others become aggressive, metastasizing from the primary site. The goal of this grant is to investigate a new mechanism of intercellular communication in cancers. This mechanism is based on lipid particles called exosomes, secreted by cancer cells and carrying within them the payload of nucleic acids and proteins. The researchers hypothesize that uptake of exosomes by neighboring non-cancerous cells may facilitate cancer progression and metastasis. The goal of the work will be to develop novel sensing techonologies for detection of exosome production and novel cell culture approaches for assessing the impact of exosome-producing cancer cells on neighboring non-cancer cells. The research efforts will focus on the study of liver cancer.