COLLABORATIVE RESEARCH: Virus removal in membrane bioreactors: Role of virus aggregation and adhesion

合作研究:膜生物反应器中的病毒去除:病毒聚集和粘附的作用

基本信息

  • 批准号:
    1236672
  • 负责人:
  • 金额:
    $ 19.06万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-01-01 至 2016-12-31
  • 项目状态:
    已结题

项目摘要

1236672/1236393Nguyen/Tarabara Aerobic membrane bioreactors (MBRs) have become a state-of-the-art technology for municipal and industrial wastewater treatment. Compared to traditional activated sludge reactors, advantages of MBR include smaller footprint and better effluent quality. MBRs have become a particularly attractive treatment choice for water reuse. In reuse applications or when the effluent is released to sensitive water bodies such as recreational water, it is especially important that viral pathogens are removed so that public health is not threatened. Comprehensive studies of virus fate in MBRs are currently lacking yet required for wider application of MBR technology, including decentralized water reuse with variable influent quality. The PIs will systematically investigate the role of virus adhesion and aggregation on virus removal in MBRs. The central hypothesis is that the extent of virus adhesion to extracellular polymeric substances (EPS) and soluble microbial products (SMP) counter-correlates with virus passage through the membrane. The experimental plan consists of the following tasks: (1) conduct bench-scale aerobic MBR studies with flat sheet and hollow fiber membranes of varied pore size; in a subset of tests operating conditions will mimic those used in the CH2M Hill full-scale MBR facility in Traverse City, MI, (2) characterize SMP, EPS, and membrane biofilm harvested from the bench-scale MBR system and the full-scale MBR plant, (3) quantify virus aggregation and adhesion to fouled membranes using SMP and EPS characterized in Task 2, (4) correlate adhesion and aggregation with the removal of virus by fouled membranes at different stages of biofilm development, and (5) evaluate virus removal in MBRs using cell culture-dependent methods and quantitative PCR. Adenovirus is selected as target virus for this study. The findings will have the potential for transforming MBR design criteria particularly as they pertain to membrane selection. While MBR-based treatment relies on the membrane to ensure an appropriate separation barrier, virus removal has not been a criterion in designing MBRs. As our technological, economic and social attitudes and approaches toward water shift from the unidirectional resource-to-waste approach toward the concept of sustainable reuse, stricter control over microbiological quality of treated used water becomes a question of when rather than if. With this in mind, we see the practical end of the research we propose in informing the decision-making process reqiered for the development of water reuse policies and regulations of the near future. Successful completion of this project will provide scientific basis for re-conceptualizing MBR design and operation to accommodate virus removal as one of design criteria and treatment goals. The project brings together a diverse team of PIs with a complimentary set of skills including interfacial science, membrane processes, and environmental microbiology and an industrial partner representing a full-scale MBR facility. A group of graduate and undergraduate students co-advised by all PIs will be provided a range of learning opportunities in an environment that combines academic studies, laboratory research in collaboration with the industrial sector, and international work. We will organize annual mini-symposia - at UIUC (year 1), MSU (year 2), and at the Traverse City MBR facility (year 3) where project participants will present their findings, discuss future research and receive feedback from the industrial partner.
1236672/1236393 Nguyen/Tarabara好氧膜生物反应器(MBR)已成为处理城市和工业废水的最先进技术。与传统的活性污泥法相比,膜生物反应器具有占地面积小、出水水质好等优点。MBR已成为一种特别有吸引力的水回用处理选择。在再利用应用中,或当污水被排放到娱乐用水等敏感水体时,尤其重要的是清除病毒病原体,以使公众健康不受威胁。目前缺乏对MBR中病毒去向的全面研究,但需要更广泛地应用MBR技术,包括分散的可变进水水质的水回用。PIS将系统地研究MBR中病毒黏附和聚集在病毒去除中的作用。中心假设是病毒对胞外聚合物(EPS)和可溶性微生物产物(SMP)的黏附程度与病毒通过细胞膜的程度相反。实验计划包括以下任务:(1)采用不同孔径的平板膜和中空纤维膜进行好氧膜生物反应器的小试研究;在一组测试中,操作条件将模拟密歇根州特拉弗斯市CH2M Hill全尺寸MBR设施中使用的操作条件,(2)表征从小规模MBR系统和全规模MBR工厂获得的SMP、EPS和膜生物膜,(3)使用任务2中描述的SMP和EPS来量化病毒聚集和与污染膜的黏附,(4)在生物膜发展的不同阶段,黏附和聚集与污染膜去除病毒的相关性,以及(5)使用细胞培养依赖的方法和定量PCR来评估MBR中病毒的去除。腺病毒被选为本研究的靶病毒。这些发现将有可能改变MBR的设计标准,特别是当它们与膜选择有关时。虽然基于膜生物反应器的治疗依赖于膜来确保适当的分离屏障,但病毒去除并不是设计膜生物反应器的标准。随着我们对水的技术、经济和社会态度和方法从单向的资源到废物的方法转变为可持续再利用的概念,对处理过的旧水的微生物质量进行更严格的控制成为一个何时而不是是否的问题。考虑到这一点,我们看到了我们提出的研究的实际目的,即为不久的将来制定水再利用政策和法规所需的决策过程提供信息。该项目的成功完成将为重新构思MBR的设计和运行提供科学基础,以适应病毒去除作为设计标准和治疗目标之一。该项目汇集了一个多元化的PI团队,他们拥有包括界面科学、膜工艺和环境微生物学在内的一系列免费技能,以及一个代表全面MBR设施的工业合作伙伴。在所有私人投资机构的共同指导下,一批研究生和本科生将在一个结合学术研究、与工业界合作的实验室研究和国际工作的环境中获得一系列学习机会。我们将在UIUC(一年级)、密歇根州立大学(二年级)和Traverse City MBR设施(三年级)组织年度小型研讨会,项目参与者将在这些研讨会上展示他们的发现,讨论未来的研究并听取行业合作伙伴的反馈。

项目成果

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Thanh Nguyen其他文献

The effects of ownership structure on dividend policy: Evidence from seasoned equity offerings (SEOs)
股权结构对股利政策的影响:来自经验丰富的股票发行(SEO)的证据
  • DOI:
    10.1016/j.gfj.2018.06.002
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    5.2
  • 作者:
    A. Ngo;H. Duong;Thanh Nguyen;Liem Nguyen
  • 通讯作者:
    Liem Nguyen
Information Sharing in Logistics Firms: An Exploratory Study of theVietnamese Logistics Sector
物流企业的信息共享:越南物流业的探索性研究
  • DOI:
    10.1016/j.ajsl.2019.06.001
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    3.1
  • 作者:
    Hiep;Thanh Nguyen;Scott Mcdonald;Nhu Quynh Tran
  • 通讯作者:
    Nhu Quynh Tran
The Effect of Social Vulnerability on Perioperative Tonsillectomy Outcomes in Children
社会脆弱性对儿童围术期扁桃体切除术结果的影响
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Salina H. Goff;Kaci Pickett;Thanh Nguyen;K. Rove;Norman R Friedman
  • 通讯作者:
    Norman R Friedman
Physical activity in Ontario preschoolers: prevalence and measurement issues
Board 179 - Program Innovations Abstract Inmates Running the Asylum: Residents Creating Their Own Curriculum (Submission #424)
Board 179 - 项目创新抽象囚犯管理庇护所:居民创建自己的课程(提交内容

Thanh Nguyen的其他文献

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{{ truncateString('Thanh Nguyen', 18)}}的其他基金

I-Corps: Biodegradable Piezoelectric Cartilage Graft with Physical Exercise for Osteoarthritis Treatment
I-Corps:可生物降解的压电软骨移植物结合体育锻炼治疗骨关节炎
  • 批准号:
    2341853
  • 财政年份:
    2023
  • 资助金额:
    $ 19.06万
  • 项目类别:
    Standard Grant
LEAPS-MPS: Splitting All-At-Once Approach to Inverse Medium Scattering Problems
LEAPS-MPS:解决逆介质散射问题的一次性分裂方法
  • 批准号:
    2316843
  • 财政年份:
    2023
  • 资助金额:
    $ 19.06万
  • 项目类别:
    Standard Grant
Global Center Track 2: Climate Risk and Resilience: Southeast Asia as a Living Lab (SEALL)
全球中心轨道 2:气候风险和复原力:东南亚作为一个活的实验室 (SEALL)
  • 批准号:
    2330308
  • 财政年份:
    2023
  • 资助金额:
    $ 19.06万
  • 项目类别:
    Standard Grant
Collaborative Research: Plant-based Pathogen Filters
合作研究:基于植物的病原体过滤器
  • 批准号:
    2023248
  • 财政年份:
    2020
  • 资助金额:
    $ 19.06万
  • 项目类别:
    Standard Grant
Collaborative Research: Influence of Drinking Water Chemical Composition on Biofilm Properties and Decay of Disinfectant Residual: An Experimental and Modeling Study
合作研究:饮用水化学成分对生物膜特性和消毒剂残留衰减的影响:实验和模型研究
  • 批准号:
    1855609
  • 财政年份:
    2019
  • 资助金额:
    $ 19.06万
  • 项目类别:
    Standard Grant
RAPID: Characterization of Pathogens in Water, Soil and Animal Facilities for Resilience Assessment of Civil Infrastructure After Extreme Weather Events
RAPID:水、土壤和动物设施中病原体的表征,用于极端天气事件后民用基础设施的复原力评估
  • 批准号:
    1901754
  • 财政年份:
    2018
  • 资助金额:
    $ 19.06万
  • 项目类别:
    Standard Grant
IRES Water Quality and Household Energy in Post-Earthquake Nepal: Long Term Protection of Community Health
IRES 尼泊尔震后水质和家庭能源:社区健康的长期保护
  • 批准号:
    1559530
  • 财政年份:
    2016
  • 资助金额:
    $ 19.06万
  • 项目类别:
    Standard Grant
Determinants of medical equipment performance to improve management capacity within health system in Viet Nam
提高越南卫生系统管理能力的医疗设备性能的决定因素
  • 批准号:
    MR/M002306/1
  • 财政年份:
    2015
  • 资助金额:
    $ 19.06万
  • 项目类别:
    Research Grant
Collaborative Research:EARS: Creating an Ecosystem for Enhanced Spectrum Utilization Through Dynamic Market Mechanisms.
合作研究:EARS:通过动态市场机制创建增强频谱利用率的生态系统。
  • 批准号:
    1443965
  • 财政年份:
    2014
  • 资助金额:
    $ 19.06万
  • 项目类别:
    Standard Grant
US-Singapore planning visit: Survivability of human enteric virus in surface water
美国-新加坡计划访问:人类肠道病毒在地表水中的生存能力
  • 批准号:
    1066152
  • 财政年份:
    2011
  • 资助金额:
    $ 19.06万
  • 项目类别:
    Standard Grant

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