Conference: FASEB Summer Research Conference on Mitosis: Spindle Assembly and Function conference being held August 5-10, 2012 in Steamboat Springs, Colorado.

会议：FASEB 有丝分裂夏季研究会议：纺锤体组装和功能会议将于 2012 年 8 月 5 日至 10 日在科罗拉多州斯廷博特斯普林斯举行。

• 批准号: 1240213
• 负责人: Claire Walczak
• 金额: $ 0.75万
• 依托单位: Federation of Amer Societies For Exper Biology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1240213&HistoricalAwards=false
• 关键词: Conference; FASEB; Summer; Research; Mitosis

Objectives: Cell division (mitosis) is the culmination of the cell cycle, and even seemingly minute deficiencies in the molecular mechanisms that control mitosis profoundly affect the fate of the daughter cells and ultimately, the fate of the entire organism. As such, elucidating the fundamental mechanisms of cell division has been in the focus of cell biology ever since this dynamic and complex process was revealed by early microscopy. A vast number of scientists investigate various aspects of the mitotic apparatus assembly and function. In fact, the field of mitosis amalgamates molecular cell biology, biochemistry, biophysics, computational biology, and functional genomics. To foster exchange of the information and ideas, as well as to encourage new interdisciplinary collaborations funds are requested to provide NSF travel awards for young scientists (graduate students, post-docs, and junior faculty) to attend the FASEB sponsored meeting on Mitosis: Spindle Assembly and Function.Intellectual Merit: This international meeting, organized by professors Claire Walczak of Indiana University (Bloomington, Indiana, USA) and Erich Nigg of Biozentrum, University of Basel (Basel, Switzerland), will bring together approximately 175 researchers from the various subdisciplines within the field of mitosis. The overall aim of the meeting is to encourage direct exchange of ideas and experimental data among scientists who study diverse aspects of mitosis. The meeting will feature a keynote address by the eminent scientist Dr. Conly Rieder of the Wadsworth Center (Albany, NY). His lecture will focus on conceptual developments in the understanding of cell division, and it will put recently-unveiled molecular mechanisms in the context of live-cell microscopy observations made over the course of several decades. Podium presentations will feature invited internationally-renowned experts, as well as younger scientists (graduate students, post-docs, and junior faculty) whose work will be selected from the submitted abstracts. Nine platform sections covering all major aspects of mitosis will be held: 1. Mitotic spindle assembly; 2. Quantitative approaches to mitosis; 3. Centrosome structure and function; 4. Kinetochore assembly and function; 5. Chromosome structure and function; 6. Mitosis career symposium; 7. Cytokinesis and mitotic exit; 8. Chromosome segregation and aneuploidy; 9. Mitosis in Development. Of special note is the Mitosis Career Symposium in which three senior leaders in the field (Professors Dick McIntosh, MaryAnn Jordan, and Ted Salmon) will provide an overview of their many contributions to this field. In addition, the session on quantitative approaches to mitosis represents the newest multidisciplinary science that is critical to the future of this field, and the session on mitosis in development is aimed to integrate the cell biology with mitosis in the broader context of the organism. To complement the platform sessions, time will be allocated for three poster sessions, each 2 hours long. The remainder of the afternoons will be orchestrated for informal scientific exchanges to promote cross-disciplinary interactions and to nurture the initiation of new collaborations.Broader Impacts: A unique feature of the meeting is that it will focus on disseminating new cutting-edge information in a didactic and expertly assimilated form, which is essential in the rapidly changing scientific landscape of research in mitosis. Due to enormously vast and diverse professional literature it has become difficult, particularly for younger scientists who only recently entered the field, to view individual discoveries in a common perspective. In addition, because of the small size and informal nature of the meeting, this venue provides a unique opportunity for young scientists to interact with world-renowned experts in the field to gain their insight and perspective on their research. Graduate students, post-doctoral fellows, and junior faculty will all be considered for platform presentations to feature their work, and all attendees are expected to present research in platform or poster sessions to ensure that everyone actively participates in the meeting. The information gathered from this meeting will be used to advance both the research and educational goals of the meeting participants by broadly disseminating the latest information to participants, who are actively involved in graduate and undergraduate training and education at institutions throughout the world.

细胞分裂（有丝分裂）是细胞周期的高潮，即使在控制有丝分裂的分子机制中看似微小的缺陷也会深刻地影响子细胞的命运，并最终影响整个生物体的命运。因此，阐明细胞分裂的基本机制一直是细胞生物学的焦点，因为这一动态和复杂的过程是由早期显微镜揭示的。大量的科学家研究有丝分裂装置的组装和功能的各个方面。事实上，有丝分裂领域融合了分子细胞生物学、生物化学、生物物理学、计算生物学和功能基因组学。为了促进信息和思想的交流，以及鼓励新的跨学科合作，要求NSF为年轻科学家（研究生，博士后和初级教师）提供旅行奖励，以参加FASEB主办的有丝分裂：纺锤体组装和功能会议。智力优势：这次国际会议由印第安纳大学（Bloomington, Indiana， USA）的Claire Walczak教授和巴塞尔大学（Basel, Switzerland） Biozentrum的Erich Nigg教授组织，将汇集来自有丝分裂领域各个分支学科的大约175名研究人员。会议的总体目标是鼓励研究有丝分裂不同方面的科学家直接交流思想和实验数据。会议将由沃兹沃斯中心（纽约州奥尔巴尼）的著名科学家康利·里德博士发表主旨演讲。他的演讲将集中在理解细胞分裂的概念发展上，并将最近揭示的分子机制置于几十年来活细胞显微镜观察的背景下。演讲台将邀请国际知名专家，以及年轻科学家（研究生、博士后和初级教师），他们的工作将从提交的摘要中选出。将举行九个平台部分，涵盖有丝分裂的所有主要方面：有丝分裂纺锤体装配；2. 有丝分裂的定量方法；3. 中心体结构与功能；4. 着丝点的组装和功能；5. 染色体结构与功能；6. 有丝分裂职业研讨会；7. 细胞分裂和有丝分裂退出；8. 染色体分离和非整倍体；9. 发育中的有丝分裂。特别值得注意的是有丝分裂职业研讨会，该领域的三位资深领导者（Dick McIntosh教授，MaryAnn Jordan教授和Ted Salmon教授）将概述他们在该领域的许多贡献。此外，有丝分裂的定量方法会议代表了对该领域未来至关重要的最新多学科科学，而有丝分裂的发展会议旨在将细胞生物学与有丝分裂在更广泛的生物体背景下结合起来。为了配合平台会议，我们将安排三次海报会议，每次2小时。下午的剩余时间将安排为非正式的科学交流，以促进跨学科的互动和培育新的合作。更广泛的影响：会议的一个独特之处在于，它将侧重于以教学和专业吸收的形式传播新的前沿信息，这在有丝分裂研究快速变化的科学景观中至关重要。由于专业文献的浩瀚和多样化，很难从一个共同的角度来看待个别的发现，特别是对刚刚进入这个领域的年轻科学家来说。此外，由于会议的小型和非正式性质，该地点为年轻科学家提供了与该领域世界知名专家互动的独特机会，以获得他们对其研究的见解和观点。研究生、博士后研究员和初级教师都将被考虑在平台上展示他们的工作，所有与会者都应该在平台或海报会议上展示研究成果，以确保每个人都积极参与会议。从本次会议收集的信息将用于促进与会者的研究和教育目标，向与会者广泛传播最新信息，他们在世界各地的机构积极参与研究生和本科生的培训和教育。