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Femtosecond Stimulated Raman Scattering, Time Resolved Dynamics, and Electron-Nuclear coupling in Biomolecules

生物分子中的飞秒受激拉曼散射、时间分辨动力学和电子核耦合

基本信息

批准号：
1243948
负责人：
Paul Champion
金额：
$ 63.6万
依托单位：
Northeastern University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2018-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1243948&HistoricalAwards=false
关键词：
Femtosecond Stimulated Raman Scattering Time

项目摘要

In this award, funded by the Chemical Structure, Dynamics, and Mechanisms Program (A) of the Division of Chemistry, the Molecular Biophysics Program of the Division of Molecular and Cellular Biosciences, and the Physics of Living Systems Program of the Division of Physics, Prof. Paul M. Champion at Northeastern University will use modern, ultrafast laser methods to study the ways in which biomolecular systems use thermal energy to carry out and control biochemical reactions. In particular, Prof. Champion and his research group will use vibrational coherence spectroscopy (VCS) and femtosecond stimulated Raman scattering (FSRS) will be used to probe the ways in which low-frequency vibrations of complex biomolecules influence or modify the reactivity of large biomolecules.Understanding the chemical reactivity of biomolecular systems is critical towards understanding the way that biological systems operate at the macroscopic scale. Advances in this field will yield advances in medicine and biotechnology. The undergraduate and graduate students working with Prof. Champion will receive excellent training in cutting-edge science at the intersection of Biology and the Physical Sciences. Prof. Champion is also actively collaborating with scientists from underrepresented groups at Northeastern as well as in Puerto Rico.

在这个奖项，由化学系的化学结构，动力学和机制计划（A），分子和细胞生物科学系的分子生物物理计划，以及物理系的生命系统物理计划资助，Paul M.东北大学的Champion将使用现代超快激光方法来研究生物分子系统使用热能进行和控制生化反应的方式。特别是Champion教授及其研究小组将使用振动相干光谱（Vibrational Coherence Spectroscopy，简称SPR）和飞秒受激拉曼散射（FSRS）来探测复杂生物分子的低频振动如何影响或改变大生物分子的反应性。了解生物分子系统的化学反应性对于理解生物系统在宏观尺度上的运作方式至关重要。这一领域的进步将带来医学和生物技术的进步。与冠军教授合作的本科生和研究生将在生物学和物理科学的交叉点接受尖端科学的优秀培训。冠军还积极与科学家从代表性不足的群体在东北部以及在波多黎各。