SusChEM: CAREER: Synthesis of Macrocyclic Carbene Complexes for Catalytic Aziridination
SusChEM: CAREER: Synthesis of Macrocyclic Carbene Complexes for Catalytic Aziridination
批准号:
1254536
负责人:
David Jenkins
金额:
$65.0万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-05-01 至 2019-04-30
中文摘要
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英文摘要
The Chemical Catalysis Program of the NSF Division of Chemistry supports the research efforts of Professor David M. Jenkins of the University of Tennessee at Knoxville (UTK) to explore new aziridination reactions using organic azides (both aryl and alkyl variants) as the nitrene source and alkenes as the carbon source. This innovative reaction involves novel transition metal complexes supported by strong sigma-donor macrocyclic tetra-N-heterocyclic carbenes (NHCs) as auxiliary ligands which act as homogeneous azirdination catalysts. The research is accomplished in four steps: ligation of tetracarbenes to first and second row transition metals (especially iron), catalytic studies of aziridination reactions between organic azides and alkenes, mechanistic studies of the reaction through probes of intermediates (i.e., metal imide complexes), and expansion of substrate scope to make the reactions relevant to industrial, pharmaceutical, and biological applications. The broader impacts of this work include providing opportunities for pre-college scholars from Central High School (CHS), an economically-disadvantaged high school in Knoxville, TN, to perform research at the UTK. With the assistance of high school teachers at CHS and collaborators in the Knox County School District, new Advanced Placement (AP) laboratories that match Professor Jenkins's research interests are being developed within the guidelines of the AP Chemistry curriculum. The laboratory capabilities at CHS are being upgraded in order to support the new experiments. Finally, in addition to the typical technical presentations and publications, these research results are being disseminated though the Pre-Game Showcase at UTK football games.Aziridine compounds are found in natural products, such as mitomycins and azinomycins, that have antitumor and antibiotic properties crucial to the development of new pharmaceutical products. Despite the myriad of uses, the synthesis of aziridine compounds has been wasteful and expensive due to the need for additional reagents that are not fully used in the final products. This CAREER project utilizes less expensive metal-based catalytic processes to avoid the need for expensive reagents. The improved reactions are expected to have impact in biology and synthetic organic chemistry, particularly in the preparation of new medicines. In his work with teachers and administrators at Central High School in Knoxville, Tennessee, Professor Jenkins stresses the use of sustainable processes in the development of new laboratories for the Advanced Placement (AP) Chemistry courses. Professor Jenkins publishes his work in technical journals but also disseminates his group's results in non-traditional forums, such as the Pre-Game Showcase at the University of Tennessee Knoxville football games.
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NP Consolidated Grant York
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批准号:ST/Y000285/1
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项目类别:Research Grant
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资助金额:$426.26万
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财政年份:2024
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负责人:David Jenkins
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依托单位:
3D Radioactive Scanning System (3D-RSS)
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批准号:ST/X000842/1
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项目类别:Research Grant
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资助金额:$20.47万
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财政年份:2023
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负责人:David Jenkins
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依托单位:
A novel sensor platform for early detection of pancreatic cancer
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批准号:BB/X004775/1
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项目类别:Research Grant
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资助金额:$23.17万
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财政年份:2023
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负责人:David Jenkins
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依托单位:
CAS: Chiral Epoxidation and Oxaziridination Catalysis with First-row Transition Metals
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批准号:2154697
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项目类别:Continuing Grant
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资助金额:$62.5万
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财政年份:2022
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负责人:David Jenkins
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依托单位:
Collaborative Research: Metal-Organic Nanotubes as Tunable Porous Fibers
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批准号:2207224
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项目类别:Continuing Grant
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资助金额:$45.59万
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财政年份:2022
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负责人:David Jenkins
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依托单位:
UoY - Nuclear Physics STFC KE and commercialisation fellow
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批准号:ST/W002086/1
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项目类别:Fellowship
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资助金额:$38.63万
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财政年份:2022
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负责人:David Jenkins
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依托单位:
RADCASE: Functional materials for radiation detection
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批准号:ST/W000709/1
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项目类别:Research Grant
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资助金额:$11.29万
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财政年份:2021
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负责人:David Jenkins
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依托单位:
Collaborative Research: Characterization and Optimization of N-Heterocyclic Carbene Functionalized Nanoparticle Systems
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批准号:2108328
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项目类别:Standard Grant
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资助金额:$36.59万
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财政年份:2021
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负责人:David Jenkins
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依托单位:
Nuclear Physics Consolidated Grant 21-24 - University of York
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批准号:ST/V001035/1
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项目类别:Research Grant
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资助金额:$235.78万
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财政年份:2021
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负责人:David Jenkins
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依托单位:
Modern African Nuclear DEtector LAboratory
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批准号:ST/S003118/1
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项目类别:Research Grant
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资助金额:$52.77万
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财政年份:2019
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负责人:David Jenkins
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依托单位:
NUTRAIN: Translating nuclear applications from University of York to University of Western Cape and University of Zululand
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批准号:ST/R002649/1
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项目类别:Research Grant
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资助金额:$12.75万
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财政年份:2018
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负责人:David Jenkins
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依托单位:
Stability and Thermochemistry of some Chlorine-bearing Calcium Amphiboles
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批准号:1725053
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项目类别:Standard Grant
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资助金额:$28.91万
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财政年份:2017
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负责人:David Jenkins
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依托单位:
Collaborative Research: N-Heterocyclic Carbene Functionalized Metal Films and Nanoparticles for Next-Generation Surface-Enhanced Spectroscopy and Sensing
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批准号:1709468
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项目类别:Standard Grant
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资助金额:$31.0万
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财政年份:2017
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负责人:David Jenkins
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依托单位:
Community-scale Energy Demand Reduction in India (CEDRI)
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批准号:EP/R008655/1
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项目类别:Research Grant
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资助金额:$75.6万
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财政年份:2017
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负责人:David Jenkins
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依托单位:
New generation nuclear detectors for use in well logging
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批准号:ST/L006251/1
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项目类别:Research Grant
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资助金额:$13.0万
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财政年份:2014
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负责人:David Jenkins
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依托单位:
Experimental Investigation of Chlorine Substitution into Calcic Amphiboles
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批准号:1347463
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项目类别:Standard Grant
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资助金额:$26.47万
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财政年份:2014
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负责人:David Jenkins
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依托单位:
High-Performance Portable Isotope Identification
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批准号:ST/M000044/1
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项目类别:Research Grant
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资助金额:$14.5万
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财政年份:2014
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负责人:David Jenkins
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依托单位:
Single atom imaging
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批准号:ST/K00199X/1
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项目类别:Research Grant
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资助金额:$5.25万
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财政年份:2012
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负责人:David Jenkins
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依托单位:
GAmma detection with New Advanced Scintillators - GANAS
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批准号:ST/J002747/1
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项目类别:Research Grant
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资助金额:$11.22万
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财政年份:2011
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负责人:David Jenkins
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依托单位:
Experimental Investigation of Glaucophane Solid Solution with Several Calcic Amphiboles
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批准号:0947175
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项目类别:Standard Grant
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资助金额:$25.42万
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财政年份:2010
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负责人:David Jenkins
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依托单位:
海外基金