CAREER: Effects of emotion on hippocampal representations and memory retrieval

职业：情绪对海马表征和记忆检索的影响

• 批准号: 1256941
• 负责人: Isabel Muzzio
• 金额: $ 65万
• 依托单位: University of Pennsylvania
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1256941&HistoricalAwards=false
• 关键词: CAREER; Effects; emotion; hippocampal; representations

Emotions have been shown to have profound and long-lasting effects on memory. In particular, negative emotional memories can remain salient even years after a traumatic episode occurs. In some cases, such as in post-traumatic stress disorder (PTSD), traumatic memories are improperly retrieved and often interfere with daily life. The hippocampus, an area involved in memory formation, plays an important role in learned fear of a context. However, the specific ways in which emotional information is stored in hippocampal subregions are not well understood.This project will investigate the roles of the dorsal and ventral regions of the hippocampus in the encoding and consolidation of fear memories by combining in vivo recordings in freely moving mice with genetic, computational, and behavioral tools to evaluate how the firing properties of hippocampal neurons change over time as animals form and retrieve emotional memories. The expectation is that contextual representations in the dorsal and the ventral hippocampus will change as animals learn that a specific location is fearful. These experiments will be critical to our understanding of how episodic fear memories are encoded along the longitudinal hippocampal axis. The broader impact of this project will be to expand interest in the field of neuroscience by enhancing local infrastructure for education through contributions to the Neuroscience in Your World program organized by the Franklin Institute and the University of Pennsylvania. Also, the tools developed for this program will be linked to the Resources for Science Learning at http://www.fi.edu, an educational website that welcomes 1 million visits per month.

情绪已经被证明对记忆有深远而持久的影响。特别是，负面的情绪记忆甚至在创伤事件发生多年后仍然很突出。在某些情况下，例如在创伤后应激障碍（PTSD）中，创伤记忆被不适当地检索，并且经常干扰日常生活。海马体是一个参与记忆形成的区域，在学习恐惧中起着重要作用。然而，情绪信息在海马亚区储存的具体方式还不太清楚，本项目将通过结合自由移动小鼠的体内记录和遗传、计算、和行为工具，以评估海马神经元的放电特性如何随着动物形成和检索情感记忆的时间而变化。我们的预期是，当动物学习到一个特定的位置是可怕的时，背侧和腹侧海马体中的情境表征会发生变化。这些实验对于我们理解情景性恐惧记忆是如何沿着纵向海马轴沿着编码的至关重要。该项目的更广泛的影响将是通过对富兰克林研究所和宾夕法尼亚大学组织的“你的世界中的神经科学”项目的贡献来加强当地的教育基础设施，从而扩大对神经科学领域的兴趣。此外，为该计划开发的工具将链接到http://www.fi.edu的科学学习资源，这是一个每月欢迎100万次访问的教育网站。