RUI-Benzannulated antiaromatic dications and dianions: using antiaromaticity to probe delocalization

通过这个奖项，由化学系的化学结构，动力学和机制-B计划资助，Trinity大学的Nancy米尔斯博士将研究影响反芳族二价阳离子和二价阴离子修饰离域的因素。反芳族物质已被证明是更敏感的影响离域的因素，因为它们的内在趋势，以避免离域，这导致在反芳性的增加。例如，通过将多种多环芳族化合物成环为阳离子，可以探测正电荷离域的能量优势与来自完整多环芳族化合物的稳定性之间的张力。反芳族二价阴离子也可通过实验获得。初步研究表明，它们比相应的dications更反芳香。改变环庚三烯基阴离子体系的苯环化位置也会通过离域模式的不同而导致反芳香性的不同。稳定性是化学中最重要的概念之一，因为所有的化学反应都是为了使最稳定的分子成为可能。有一类化合物被称为反芳香族化合物，理论上认为它们特别不稳定。不用说，这些化合物还没有被仔细研究，因为预期的困难，使他们。然而，人们在尝试制造其他东西时发现了一系列这些化合物，并且已经证明它们比预期的更容易制造和研究。因为它们仍然相对不稳定，所以它们对结构的变化非常敏感。就像房屋或汽车等物理结构的某些变化在黄昏的昏暗光线下可能很难看到，但在白天却非常明显一样，在稳定的分子结构中难以理解的变化，在不太稳定的反芳香化合物中变得非常明显。这些研究将由本科生进行，重点是刚刚开始学习化学的学生。通过让这些学生在学术生涯的早期参与研究，他们能够更好地了解他们最感兴趣的科学方面，并在课程中做出选择以支持这种兴趣。他们将得到博士后研究人员的帮助，他们有兴趣将本科生作为职业。培训本科生和未来教师所固有的劳动力发展是赠款的主要广泛影响。

Through this award, funded by the Chemical Structure, Dynamics, and Mechanisms-B Program of the Division of Chemistry, Dr. Nancy Mills of Trinity University will examine the factors that affect delocalization by modification of antiaromatic dications and dianions. Antiaromatic species have been shown to be more sensitive to factors affecting delocalization because of their inherent tendency to avoid delocalization which results in an increase in antiaromaticity. For example, by annulation of a variety of polycyclic aromatic compounds to a cyclopentadienyl cation, the tension between the energetic advantages of delocalization of positive charge versus the stability from the intact polycyclic aromatic compound can be probed. Antiaromatic dianions are also accessible experimentally. Initial studies suggest that they are more antiaromatic than corresponding dications. Varying the position of benzannulation of a cycloheptatrienyl anionic system can again result in differences in antiaromaticity through differences in patterns of delocalization.Stability is one of the most important concepts in chemistry because all chemical reactions result in making the most stable molecules possible. There is a class of compounds, called antiaromatic, which have been suggested by theory to be particularly unstable. Needless to say, these compounds have not been carefully studied because of the anticipated difficulty in making them. However, a suite of these compounds was discovered in an attempt to make something else and have proven to be much easier to make and study than anticipated. Because they are still relatively unstable, they turn out to be very sensitive to changes in their structure. Just as some changes in a physical structure, like a house or an automobile, might be hard to see in the dim light of dusk, but be very visible in daylight, changes that are hard to understand in a molecular structure that is stable, become very visible in a less stable, antiaromatic compound. These studies will be carried out by undergraduate students, with an emphasis on students just beginning their study of chemistry. By engaging these students in research early in their academic career, they are in a better position to learn what aspects of science interest them the most, and to make choices in coursework to support that interest. They will be aided by post-doctoral researchers who are interested in teaching undergraduate students as a career. The workforce development inherent in training undergraduates and prospective faculty is the primary broader impact of the grant.