RUI-Antiaromaticity of Indenylidene Dications and the Aromaticity/Antiaromaticity Continuum
RUI-茚亚基双阳离子的反芳香性和芳香性/反芳香性连续体
基本信息
- 批准号:0242227
- 负责人:
- 金额:$ 25.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-05-15 至 2007-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The concepts of aromaticity and antiaromaticity play central roles in organic chemistry. Although somewhat elusive concepts, a combination of experimental and calculational tools may be used to assess aromacity and antiaromaticity through analysis of magnetic, structural, and energetic criteria. Indenylidene dications allow the assessment of magnetic properties through the paratropicity of protons on both the five- and six-membered rings, allowing evaluation of the antiaromaticity suggested by the nucleus independent chemical shift values. Because the cyclopentadienyl ring of the indenylidene cation can respond to increased antiaromaticity through deformation, structural properties can be assessed. Energetic properties can be assessed by electrochemical oxidation and comparison of redox potentials with those of non-antiaromatic model systems. By playing the various criteria against each other in aromatic and antiaromatic systems, the criteria that most effectively define aromatic/antiaromatic systems will be exposed.Ever since the initial realization that benzene and related "aromatic" hydrocarbons display unusually high stability, the factors responsible for this stability have been of great interest. "Aromaticity" and its counterpoint, antiaromaticity, in which compounds display lower than anticipated stability, play central roles in defining organic chemical structure and reactivity. With the support of a Research at Undergraduate Institutions (RUI) grant from the Organic and Macromolecular Chemistry Program, Professor Nancy S. Mills, of the Department of Chemistry at Trinity University, is exploring new molecular systems expected to display antiaromaticity. Through the rational design and synthesis of appropriate organic molecules and analysis of their magnetic, structural, and energetic properties, Professor Mills is defining the criteria that most effectively define aromaticity and antiaromaticity. A large number of undergraduate research assistants will participate in these studies, providing them with valuable research experience and education in a variety of experimental, instrumental, and theoretical techniques.
芳香性和反芳香性的概念在有机化学中起着中心作用。虽然有些难以捉摸的概念,实验和计算工具的组合可以用来评估芳香性和反芳香性通过分析磁性,结构和能量标准。茚基dications允许通过在五元环和六元环上的质子的顺磁性来评估磁性,允许评估由核独立化学位移值所建议的反芳香性。由于亚茚基阳离子的反式环化可以通过变形对增加的反芳香性作出响应,因此可以评估结构性质。能量性质可以通过电化学氧化和与非反芳模型系统的氧化还原电位的比较来评估。通过在芳族和反芳族体系中使用不同的标准来相互对抗,最有效地定义芳族/反芳族体系的标准将被暴露。自从最初认识到苯和相关的“芳族”烃显示出异常高的稳定性以来,对这种稳定性负责的因素引起了极大的兴趣。“芳香性”及其对应物,反芳香性,其中化合物显示出低于预期的稳定性,在定义有机化学结构和反应性方面起着核心作用。在有机和高分子化学项目的本科院校研究资助的支持下,南希S。Trinity大学化学系的米尔斯正在探索有望显示反芳香性的新分子系统。通过合理设计和合成适当的有机分子,并分析其磁性,结构和能量特性,米尔斯教授正在定义最有效地定义芳香性和反芳香性的标准。大量的本科生研究助理将参与这些研究,为他们提供宝贵的研究经验和各种实验,仪器和理论技术的教育。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Nancy Mills其他文献
New strategies for union survival and revival
- DOI:
10.1007/s12122-001-1023-x - 发表时间:
2001-09-01 - 期刊:
- 影响因子:1.400
- 作者:
Nancy Mills - 通讯作者:
Nancy Mills
Erratum to: A pilot study of dose-dense adjuvant paclitaxel without growth factor support for women with early breast carcinoma
- DOI:
10.1007/s10549-009-0482-2 - 发表时间:
2009-07-22 - 期刊:
- 影响因子:3.000
- 作者:
Steven Sugarman;Carolyn Wasserheit;Elizabeth Hodgman;Maryellen Coglianese;Anne D’Alassandro;Monica Fornier;Tiffany Troso-Sandoval;Gabriella D’Andrea;Pamela Drullinsky;Diana Lake;Roshini George;Nancy Mills;Maryellen Moynahan;Joyce Smith;Katherine Panageas;Larry Norton;Clifford Hudis - 通讯作者:
Clifford Hudis
Nancy Mills的其他文献
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{{ truncateString('Nancy Mills', 18)}}的其他基金
RUI-Benzannulated antiaromatic dications and dianions: using antiaromaticity to probe delocalization
RUI-苯扎环反芳香双键和双阴离子:利用反芳香性探测离域
- 批准号:
1265545 - 财政年份:2013
- 资助金额:
$ 25.3万 - 项目类别:
Standard Grant
MRI-R2: Acquisition of a 500 MHz NMR spectrometer by Trinity University
MRI-R2:三一大学购买 500 MHz NMR 波谱仪
- 批准号:
0957839 - 财政年份:2010
- 资助金额:
$ 25.3万 - 项目类别:
Standard Grant
RUI-Antiaromatic Hydrocarbon Dications and Hydrocarbon/Heterocylic Dianions: The Relationship between Delocalization and Antiaromaticity
RUI-反芳香烃双阳离子和烃/杂环双阴离子:离域与反芳香性之间的关系
- 批准号:
0948445 - 财政年份:2010
- 资助金额:
$ 25.3万 - 项目类别:
Standard Grant
RUI: The Role of Bond Localization in Antiaromaticity: Aromaticity/Antiaromaticity Continuum for Indenyl Systems
RUI:键定位在反芳香性中的作用:茚基系统的芳香性/反芳香性连续体
- 批准号:
0553589 - 财政年份:2006
- 资助金额:
$ 25.3万 - 项目类别:
Standard Grant
Establishment of a Regional NMR Site at Trinity University
在三一大学建立区域核磁共振站点
- 批准号:
0126417 - 财政年份:2002
- 资助金额:
$ 25.3万 - 项目类别:
Standard Grant
Development of a Molecular Computing Laboratory
分子计算实验室的发展
- 批准号:
9151353 - 财政年份:1991
- 资助金额:
$ 25.3万 - 项目类别:
Standard Grant
ARFMP: Renovation of Chemistry Departmental Research Laboratories
ARFMP:化学系研究实验室的改造
- 批准号:
9021739 - 财政年份:1991
- 资助金额:
$ 25.3万 - 项目类别:
Standard Grant
Human Performance Laboratory Improvement for Enhanced Pro- ductivity Management Instruction
人类绩效实验室改进以增强生产力管理指导
- 批准号:
9050799 - 财政年份:1990
- 资助金额:
$ 25.3万 - 项目类别:
Standard Grant
Optical Activity Determinations in Chemistry and Biochemistry
化学和生物化学中的旋光度测定
- 批准号:
8750180 - 财政年份:1987
- 资助金额:
$ 25.3万 - 项目类别:
Standard Grant
Metallacyclobutanes and Trimethylenemethane Metal Complexes via Delocalized Dianions
通过离域二价阴离子形成金属环丁烷和三亚甲基甲烷金属配合物
- 批准号:
8506038 - 财政年份:1985
- 资助金额:
$ 25.3万 - 项目类别:
Continuing Grant
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Real-World Applications of the Antiaromaticity Concept: Assemblies, Synthetic Strategies, and Functional Properties
反芳香性概念的实际应用:组装、合成策略和功能特性
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2246964 - 财政年份:2023
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RUI-Benzannulated antiaromatic dications and dianions: using antiaromaticity to probe delocalization
RUI-苯扎环反芳香双键和双阴离子:利用反芳香性探测离域
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RUI-反芳香烃双阳离子和烃/杂环双阴离子:离域与反芳香性之间的关系
- 批准号:
0948445 - 财政年份:2010
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$ 25.3万 - 项目类别:
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- 资助金额:
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