MRI-R2: Acquisition of a 500 MHz NMR spectrometer by Trinity University

MRI-R2：三一大学购买 500 MHz NMR 波谱仪

• 批准号: 0957839
• 负责人: Nancy Mills
• 金额: $ 49.85万
• 依托单位: Trinity University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0957839&HistoricalAwards=false
• 关键词: MRI; R2; Acquisition; 500; MHz

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research Instrumentation (MRI) program Professor Nancy S. Mills and colleagues Jessica Hollenbeck, Laura Hunsicker-Wang and Adam R. Urbach from the Department of Chemistry at Trinity University will acquire a 500 MHz NMR spectrometer equipped with a broad band probe. The instrument will be used to support research activities such as: 1) probing the conformational flexibility of designed ankyrin-repeat proteins; 2) studying the cooperation of intermolecular interactions within the framework of a rigid DNA duplex in complexes containing polyamide ligands; 3) examination of the pH dependence of the redox behavior of Rieske proteins through chemical modification of potential titratable groups to characterize modified amino acids; and 4) evaluation of interactions of lithium counterions with antiaromatic dianions.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。米尔斯及其同事杰西卡·霍伦贝克、劳拉·亨塞克-王和亚当·R·来自Trinity大学化学系的Urbach将获得一台配备宽带探头的500 MHz NMR光谱仪。该仪器将用于支持以下研究活动：1）探测设计的锚定重复序列蛋白的构象柔性; 2）研究含有聚酰胺配体的复合物中刚性DNA双链体框架内分子间相互作用的协作;第三章通过潜在可滴定基团的化学修饰来表征修饰的氨基，酸;核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为教学和研究的一个组成部分。