Catalysis Chemistry Involving Nucleosides and Related Heterocycles

涉及核苷和相关杂环的催化化学

• 批准号: 1265687
• 负责人: Mahesh Lakshman
• 金额: $ 50万
• 依托单位: CUNY City College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1265687&HistoricalAwards=false
• 关键词: Catalysis; Chemistry; Involving; Nucleosides; Related

The Chemical Catalysis Program of the Chemistry Division at the National Science Foundation supports the research and pedagogical activities of Prof. Mahesh K. Lakshman at The City College and The City University of New York. Professor Lakshman's research involves the chemical modification of nucleosides and purine derivatives as well as closely related heterocycles, using catalysis methodology. Studies are conducted on metal-catalyzed carbon-carbon and carbon-nitrogen bond-formation methodologies. There are several aims of the research: chemoselective and room-temperature transformations of nucleosides, design of new ligands for modulation of catalytic conversions, development of benzotriazolyl nucleoside analogues, and use of pyrimidine, quinazoline, and purine as potentially disposable handles for functionalization of organic molecules. Professor Lakshman collaborates with researchers at several national and international institutions to access the activity of the new nucleosides and related heterocycles created as part of this project. The research has various levels of complexity and students at all educational levels participate in the program. In addition, this research has led to opportunities for outreach to local schools and colleges. Metal-catalyzed reactions offer a state-of-the-art approach to assembling complex molecular structures, often not accessible by other means. Nucleosides and purines are highly important biomolecules with applications in biochemistry, biology, and medicine. Metal-catalyzed reactions of nucleosides and purines allow for ready diversification of these biochemical scaffolds and provide access to previously unknown molecular architectures. Metal catalysis also offers access to molecules that resemble nucleosides, and the intrinsic chemical reactivity of purines and related heterocycles can potentially be exploited in new ways. New nucleosides and related heterostructures that are produced as part of this research are evaluated at several schools of pharmacy and medical institutions as potential anti-viral or anti-HIV medicines as well as treatments for cardiovascular disease and cancer. Students at various educational levels, including those from local middle and high schools and colleges, gain training in contemporary chemistry and professional preparation by participating in this research project.

美国国家科学基金会化学部的化学催化计划支持马赫什·K·拉克什曼教授在城市学院和纽约城市大学的研究和教学活动。拉克什曼教授的研究涉及使用催化方法对核苷和嘌呤衍生物以及密切相关的杂环进行化学修饰。研究了金属催化的碳-碳和碳-氮键形成方法。这项研究的目的有几个：核苷的化学选择性和室温转化，设计新的配体来调节催化转化，开发苯并三氮唑核苷类似物，以及使用嘧啶、喹唑啉和嘌呤作为潜在的一次性处理有机分子的官能化处理。拉克什曼教授与几个国家和国际机构的研究人员合作，获取作为该项目的一部分而创建的新核苷和相关杂环的活动。这项研究具有不同程度的复杂性，所有教育水平的学生都参与了该计划。此外，这项研究还带来了接触当地学校和大学的机会。金属催化的反应提供了一种最先进的方法来组装复杂的分子结构，这通常是其他方法无法实现的。核苷和嘌呤是非常重要的生物大分子，在生物化学、生物和医学等领域有着广泛的应用。金属催化的核苷和嘌呤的反应使这些生化支架易于多样化，并提供了进入以前未知的分子结构的途径。金属催化还提供了获得类似核苷的分子的途径，嘌呤和相关杂环的内在化学反应能力可能会被以新的方式开发。作为这项研究的一部分，新的核苷和相关的异质结构在几所药房和医疗机构作为潜在的抗病毒或抗艾滋病毒药物以及心血管疾病和癌症的治疗药物进行了评估。不同教育水平的学生，包括来自当地初中、高中和大学的学生，通过参与这一研究项目，获得现代化学和专业准备的培训。