Acquisition of a 500 MHz NMR Spectrometer for Research and Education

在主要研究仪器计划(MRI)的这一奖项下，纽约市立大学-市立大学校区的化学系将获得一台500 MHz核磁共振光谱仪。该设备将使研究人员能够开展以下研究：(I)化学修饰的核苷和脱氧核糖核酸的研究；(Ii)特殊核苷的合成及其含有核苷的脱氧核糖核酸的研究；(Iii)高能量密度N-硝氨基和双二氟氨基固体推进剂的合成；(Iv)部分分离蛋白质片段的结构和动力学研究，以了解蛋白质的展开状态；(V)针对艾滋病相关机会性感染的新型药效团；(Vi)短乳杆菌S层蛋白质的研究；以及(Vii)呋喃二烯糖苷的合成。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对包括合成化学、药物化学和生物学在内的许多领域产生影响。

With this award from the Major Research Instrumentation Program (MRI) Program, the Department of Chemistry at the City University of New York - City College Campus will acquire a 500 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on (i) studies of chemically modified nucleosides and DNA; (ii) synthesis of unusual nucleosides and studies on DNA containing them; (iii) synthesis of high energy-density N-nitramino and geminal difluoramino solid propellants; (iv) studies of the structure and dynamics of selected isolated protein fragments to learn about the unfolded state of proteins; (v) novel pharmacophores against opportunistic infections related to AIDS; (vi) studies of the S-layer protein of Lactobacillus brevis; and (vii) synthesis of enediyne glycofuranosides. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including synthetic chemistry, pharmaceutical chemistry and biology.