Acquisition of a 500 MHz NMR Spectrometer for Research and Education

采购 500 MHz NMR 波谱仪用于研究和教育

• 批准号: 0210295
• 负责人: Mahesh Lakshman
• 金额: --
• 依托单位: CUNY City College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0210295&HistoricalAwards=false
• 关键词: Acquisition; 500; MHz; NMR; Spectrometer

With this award from the Major Research Instrumentation Program (MRI) Program, the Department of Chemistry at the City University of New York - City College Campus will acquire a 500 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on (i) studies of chemically modified nucleosides and DNA; (ii) synthesis of unusual nucleosides and studies on DNA containing them; (iii) synthesis of high energy-density N-nitramino and geminal difluoramino solid propellants; (iv) studies of the structure and dynamics of selected isolated protein fragments to learn about the unfolded state of proteins; (v) novel pharmacophores against opportunistic infections related to AIDS; (vi) studies of the S-layer protein of Lactobacillus brevis; and (vii) synthesis of enediyne glycofuranosides. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including synthetic chemistry, pharmaceutical chemistry and biology.

凭借重大研究仪器计划 (MRI) 计划的这一奖项，纽约城市大学城市学院校区化学系将购买一台 500 MHz NMR 波谱仪。该设备将使研究人员能够开展以下研究：(i) 化学修饰核苷和 DNA 的研究； (ii) 异常核苷的合成以及含有它们的 DNA 的研究； (iii)高能量密度N-硝氨基和偕二氟氨基固体推进剂的合成； (iv) 研究选定的分离蛋白质片段的结构和动力学，以了解蛋白质的未折叠状态； (v) 对抗艾滋病相关机会性感染的新药效基团； (vi) 短乳杆菌S层蛋白的研究； (vii)烯二炔呋喃糖苷的合成。 核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于进行前沿研究的化学家来说，使用最先进的核磁共振波谱仪至关重要。这些核磁共振研究的结果将对合成化学、药物化学和生物学等多个领域产生影响。