Acquisition of a 500 MHz NMR Spectrometer for Research and Education

有了这个奖项从主要研究仪器计划（MRI）计划，化学系在纽约城市大学-城市学院校园将获得一个500兆赫核磁共振光谱仪。这些设备将使研究人员能够进行以下研究：㈠化学修饰核苷和脱氧核糖核酸的研究; ㈡合成不寻常的核苷和研究含有这些核苷的脱氧核糖核酸; ㈢合成高能量密度的N-硝氨基和偕二氟氨基固体推进剂; ㈣研究选定的分离蛋白质片段的结构和动力学，以了解蛋白质的未折叠状态;（v）对抗与艾滋病有关的机会性感染的新药效团;（vi）短乳杆菌S-层蛋白的研究;和（vii）烯二炔呋喃糖苷的合成。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些核磁共振研究的结果将对合成化学、药物化学和生物学等多个领域产生影响。

With this award from the Major Research Instrumentation Program (MRI) Program, the Department of Chemistry at the City University of New York - City College Campus will acquire a 500 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on (i) studies of chemically modified nucleosides and DNA; (ii) synthesis of unusual nucleosides and studies on DNA containing them; (iii) synthesis of high energy-density N-nitramino and geminal difluoramino solid propellants; (iv) studies of the structure and dynamics of selected isolated protein fragments to learn about the unfolded state of proteins; (v) novel pharmacophores against opportunistic infections related to AIDS; (vi) studies of the S-layer protein of Lactobacillus brevis; and (vii) synthesis of enediyne glycofuranosides. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including synthetic chemistry, pharmaceutical chemistry and biology.