Novel Avenues to Nucleoside Modification by Palladium Catalysis

本研究的重点是钯催化合成修饰核苷的合成方法的发展。该研究项目旨在开发利用pd催化C-N和C-C键形成来生产修饰核苷的方法。除了涉及催化本身的基础工作外，C-N键形成的特定应用将有助于开发新的方法来推进对DNA损伤的生物反应的理解。使用聚合物支持的合成技术，包括无迹连接和高通量，以多样性为导向的研究将被探索。通过这个新奖项，有机和大分子化学项目支持纽约市城市学院化学系的Mhesh K. Lakshman博士的研究和教育工作。拉克什曼教授将把他的研究重点放在开发合成含有不寻常核苷基的DNA的新方法上。这项研究将有助于从根本上理解DNA在生物活动中的作用，以及细胞如何对DNA损伤作出反应。研究生、本科生和博士后水平的化学学生将在拉克什曼教授的实验室接受培训，该实验室在培养少数民族学生方面有着良好的记录。

The focus of this research is in the development of synthetic methods for the synthesis of modified nucleosides by palladium catalysis. This research project aims will develop methods that use Pd-catalysis for C-N, and C-C bond formation to produce modified nucleosides. In addition to the fundamental work involving the catalysis itself, specific applications of C-N bond-formation will aid in developing novel approaches to advance the understanding biological responses to DNA damage. Use of polymer-supported synthesis techniques, including traceless linkers and high-throughput, diversity-oriented studies will be explored. With this new award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Mhesh K. Lakshman of the Department of Chemistry at City College in New York City. Professor Lakshman will focus his research on the development of new ways to synthesize DNA bearing unusual nucleoside bases. This research will contribute to the fundamental understanding of the role DNA plays in biological activity, and how cells respond to DNA damage. Chemistry students at the graduate, undergraduate and post-doctoral level will be trained in Professor Lakshman's laboratory, which has a strong track record of training minority students.