Novel Avenues to Nucleoside Modification by Palladium Catalysis

钯催化核苷修饰的新途径

• 批准号: 0314326
• 负责人: Mahesh Lakshman
• 金额: $ 36.8万
• 依托单位: CUNY City College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0314326&HistoricalAwards=false
• 关键词: Novel; Avenues; Nucleoside; Modification; Palladium

The focus of this research is in the development of synthetic methods for the synthesis of modified nucleosides by palladium catalysis. This research project aims will develop methods that use Pd-catalysis for C-N, and C-C bond formation to produce modified nucleosides. In addition to the fundamental work involving the catalysis itself, specific applications of C-N bond-formation will aid in developing novel approaches to advance the understanding biological responses to DNA damage. Use of polymer-supported synthesis techniques, including traceless linkers and high-throughput, diversity-oriented studies will be explored. With this new award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Mhesh K. Lakshman of the Department of Chemistry at City College in New York City. Professor Lakshman will focus his research on the development of new ways to synthesize DNA bearing unusual nucleoside bases. This research will contribute to the fundamental understanding of the role DNA plays in biological activity, and how cells respond to DNA damage. Chemistry students at the graduate, undergraduate and post-doctoral level will be trained in Professor Lakshman's laboratory, which has a strong track record of training minority students.

本研究的重点是开发通过钯催化合成修饰核苷的合成方法。 该研究项目的目标是开发利用 Pd 催化 C-N 和 C-C 键形成来生产修饰核苷的方法。 除了涉及催化本身的基础工作外，C-N 键形成的具体应用将有助于开发新方法，以促进对 DNA 损伤的生物反应的理解。 将探索使用聚合物支持的合成技术，包括无痕连接体和高通量、面向多样性的研究。 通过这一新奖项，有机和高分子化学项目将支持纽约市城市学院化学系 Mhesh K. Lakshman 博士的研究和教育工作。 Lakshman 教授的研究重点是开发合成带有不寻常核苷碱基的 DNA 的新方法。 这项研究将有助于从根本上理解 DNA 在生物活性中所扮演的角色，以及细胞如何应对 DNA 损伤。 研究生、本科生和博士后水平的化学学生将在拉克什曼教授的实验室接受培训，该实验室在培养少数民族学生方面拥有良好的记录。