Acquisition of a mass spectrometer for research and teaching

购置一台质谱仪用于研究和教学

• 批准号: 0520963
• 负责人: Mahesh Lakshman
• 金额: $ 19.13万
• 依托单位: CUNY City College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0520963&HistoricalAwards=false
• 关键词: Acquisition; mass; spectrometer; research; teaching

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at CUNY City College will acquire a time-of-flight mass spectrometer. Research programs that will be supported by this instrument include a) metal catalysis and metal catalyzed synthesis of novel nucleoside entities, carcinogen-nucleoside adducts and studies on site-specifically modified DNA; b) selective vinyl and aryl fluorination, synthesis of specifically fluorinated hydrocarbons and their metabolites, studies of conformational and biological modulation by fluorine; c) fate of organic xenobiotics in the environment and elucidation of relevant reaction mechanisms; d) studies on ligand-protein interactions as well as synthetic drug-like molecules; e) structural studies of integral membrane proteins of medical relevance; and d) synthesis and studies of furanose-based novel ene-diyne antibiotic analogs. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The results from these studies will have an impact in a number of areas including environmental chemistry and synthetic chemistry.

通过这项来自主要研究仪器（MRI）项目的奖励，纽约市立大学化学系将获得一台飞行时间质谱仪。该仪器将支持的研究项目包括a)金属催化和金属催化合成新型核苷实体，致癌核苷加合物和位点特异性修饰DNA的研究；B)选择性乙烯基和芳基氟化，特定氟化碳氢化合物及其代谢物的合成，氟对构象和生物调节的研究；C)环境中有机异种生物的命运及相关反应机制的阐明；D)配体-蛋白质相互作用以及合成类药物分子的研究；E)与医学相关的整体膜蛋白结构研究；d)呋喃糖基新型烯-二炔类抗生素类似物的合成与研究。质谱（MS）是一种用于探测内部结构细节和获得大量有机、生物有机和有机金属分子的分子组成的技术。这些研究的结果将对包括环境化学和合成化学在内的许多领域产生影响。