Controlled Polymerization of Amino Acid N-Carboxyanhydrides

氨基酸 N-羧酸酐的受控聚合

• 批准号: 0809420
• 负责人: Jianjun Cheng
• 金额: $ 39万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0809420&HistoricalAwards=false
• 关键词: Controlled; Polymerization; Amino; Acid; Carboxyanhydrides

This project aims at the development of new methods for the synthesis of polypeptides with well defined structures. Polypeptides are a class of biomaterials with numerous applications. The most economical process for synthesizing high molecular-weight polypeptides in large-scale is through the polymerization of alpha-amino acid N-carboxyanhydrides with amines as the initiators. Although polypeptides can be readily synthesized using this process, the resulting polypeptides have uncontrolled molecular weights, broad molecular weight distributions, and poorly defined end groups. This project will study the in situ silylation of amine initiators for the controlled polymerization of alpha-amino acid N-carboxyanhydrides. With this grant, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Jianjun Cheng of the Department of Materials Science and Engineering at the University of Illinois at Urbana-Champaign. Professor Cheng's research efforts involve the development of initiators for the controlled polymerization of alpha-amino acid N-carboxyanhydrides. Such chemistry will allow control over the end groups as well as the polypeptide molecular weight distribution. Successful development of this methodology has significant impact on both the pharmaceutical and biomaterials industries.

该项目旨在开发合成结构明确的多肽的新方法。多肽是一类应用广泛的生物材料。以胺为引发剂，通过α-氨基酸-N-羧酸酐聚合，是大规模合成高分子量多肽最经济的方法。虽然利用这种方法可以很容易地合成多肽，但得到的多肽具有不可控的分子量、广泛的分子量分布和不明确的端基。本项目将研究用于控制α-氨基酸N-羧酸酐聚合的胺引发剂的原位硅基化。通过这笔赠款，有机化学和高分子化学项目正在支持伊利诺伊大学香槟分校材料科学与工程系郑建军教授的研究。程教授的研究工作涉及α-氨基酸N-羧酸酐控制聚合引发剂的开发。这样的化学将允许控制端基以及多肽的分子量分布。这一方法的成功开发对制药和生物材料行业都有重大影响。