CAREER: Development of Conjugated Polymer-Drug Nanoparticulate Delivery Vehicles

职业：共轭聚合物-药物纳米颗粒输送载体的开发

• 批准号: 0748834
• 负责人: Jianjun Cheng
• 金额: $ 62.5万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2015-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0748834&HistoricalAwards=false
• 关键词: CAREER; Development; Conjugated; Polymer; Drug

This Career award by the Biomaterials program in the Division of Materials Research to University of Illinois is to develop synthetic chemistry tools to facilitate the formation of polymeric lactic acid nanoparticle utilizing drug-initiated ring-opening polymerization that precisely controls the formation of nanoparticle drug delivery system. This polymerization approach, where drug is attached to the terminal of polymer chains during polymerization would have the following unique characteristics. 1) Drug loading to polymers is completed in a drug-initiated, living polymerization process instead of being conjugated or encapsulated to an existing polymer; 2) Drug molecules quantitatively coordinate with metal catalysts and facilitate quantitative chain initiation and complete monomer consumption in the polymerization; and 3) Drug release kinetics is modulated by the degradation of polymer matrix and the hydrolysis kinetics of the cleavable polymer-drug bond with low or no burst release effect. By this approach, drug incorporation efficiency could reach 100%, and drug loading could be controlled by adjusting monomer/drug ratio. The scientific broader impact of this project is possible development of well-controlled drug delivery technologies using drug polymer particulates with clear application in medicine and food industryThe project will develop unique and innovative education and outreach programs, such as the development of a workshop on nanobiomaterials for undergraduates and mentoring these students. K-12 students will participate in the project through the Engineering Summer Programs. During the course of this project, the PI plans to develop three biomaterials courses focusing on synthesis and biomedical applications of biomaterials. In addition, a senior undergraduate course will be developed and this course will cover regulatory, legal and business aspects of biomaterials, integrating the PI's interactions with the Tech Transfer Office.

这项由伊利诺伊大学材料研究部生物材料计划颁发的职业奖项是开发合成化学工具，利用药物引发的开环聚合促进聚合乳酸纳米颗粒的形成，这种聚合精确控制纳米药物输送系统的形成。这种聚合方法在聚合过程中将药物连接到聚合链的末端，具有以下独特的特征。1)药物在聚合物中的负载是在药物引发的活性聚合过程中完成的，而不是被连接或包裹到现有的聚合物上；2)药物分子定量地与金属催化剂配位，促进聚合过程中定量的链启动和完全的单体消耗；3)药物释放动力学受聚合物基质的降解和可断裂的聚合物-药物键的水解动力学的调节，具有低的或没有突发释放效应。通过这种方法，药物的包封率可以达到100%，并且可以通过调节单体/药物的比例来控制载药量。该项目的科学影响更广泛，可能开发使用药物聚合物颗粒的良好控制的药物输送技术，并在医药和食品行业中有明确的应用。该项目将制定独特和创新的教育和推广计划，例如为本科生开发纳米生物材料研讨会，并对这些学生进行指导。K-12年级的学生将通过工程暑期项目参与该项目。在这个项目的过程中，PI计划开发三个生物材料课程，重点是生物材料的合成和生物医学应用。此外，还将开发一门高级本科课程，该课程将涵盖生物材料的监管、法律和商业方面，将PI与技术转让办公室的互动整合在一起。