Polymerization of N-carboxyanhydrides Catalyzed by Macromolecular Architecture
大分子结构催化N-羧酸酐的聚合
基本信息
- 批准号:1709820
- 负责人:
- 金额:$ 26万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-03-01 至 2021-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Polypeptides, the structural components of proteins, is an important class of biopolymers. Because of their structural and functional diversity, both naturally occurring and synthetic polypeptides are used in a wide range of applications. Professor Jianjun Cheng's research group at the University of Illinois at Urbana-Champaign develops novel strategies to synthesize polypeptides and investigates the factors that accelerate the rate of polymerization. This project provides research training to students, including members of underrepresented groups, preparing a skilled workforce for the polymer industry. Research is integrated into various educational and outreach endeavors, including the Discover Engineering Summer Camp Program and Engineering Open-House Program at the University of Illinois, for undergraduates and K-12 students.Prof. Cheng's research group aims to develop the chain growth polymerization of N-carboxyanhydride (NCA) monomers as an efficient approach to synthesize polypeptides with high conversion, high degree of polymerization, and low polydispersity. To understand the mechanism of this chemistry and the factors that control the polymerization kinetics, the research group studies the dependence of polymerization rate on monomer structures, helical conformation, additives, and solvent. The team further investigates the effects of the architecture of the initiator on the rate of NCA polymerization. The roles of architecture provided by dendrimers, micelles, and non-covalent perylene-based pi-stacks are explored.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
多肽是蛋白质的结构组分,是一类重要的生物大分子。 由于其结构和功能的多样性,天然存在的和合成的多肽都用于广泛的应用中。 伊利诺伊大学厄巴纳-香槟分校程建军教授的研究小组开发了合成多肽的新策略,并研究了加速聚合速率的因素。 该项目为学生提供研究培训,包括代表性不足的群体的成员,为聚合物行业准备熟练的劳动力。 郑教授的研究小组致力发展N-羧酸酐单体的链增长聚合反应,以高转化率、高聚合度、高分子量和高分子量的多肽为目标,和低多分散性。 为了了解这种化学反应的机理和控制聚合动力学的因素,研究小组研究了聚合速率对单体结构、螺旋构象、添加剂和溶剂的依赖性。 该团队进一步研究了引发剂结构对NCA聚合速率的影响。 该奖项反映了NSF的法定使命,并被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Enzyme-mimetic self-catalyzed polymerization of polypeptide helices
- DOI:10.1038/s41467-019-13502-w
- 发表时间:2019-11-29
- 期刊:
- 影响因子:16.6
- 作者:Song, Ziyuan;Fu, Hailin;Cheng, Jianjun
- 通讯作者:Cheng, Jianjun
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Jianjun Cheng其他文献
A novel method combining fuzzy SVM and sampling for imbalanced classification
模糊支持向量机与抽样相结合的不平衡分类新方法
- DOI:
10.1504/ijass.2018.10012176 - 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
Tao Ma;Ying Hou;Jianjun Cheng;Xiaoyun Chen - 通讯作者:
Xiaoyun Chen
Properties of saline soil stabilized with fly ash and modified aeolian sand
粉煤灰和改性风积沙稳定盐渍土的特性
- DOI:
10.1016/j.cscm.2024.e03503 - 发表时间:
2024-12-01 - 期刊:
- 影响因子:6.600
- 作者:
Yuanqing Chen;Akelamjiang. maimait;Jianjun Cheng;Yanfu Duan;Dawei Yin;Hongguang Dong;Yupeng Li - 通讯作者:
Yupeng Li
Investigating Hofmeister ions on rice starch gelatinization using simultaneous rheology and FTIR techniques combined with 2D correlation analysis
使用同步流变学和傅里叶变换红外光谱技术结合二维相关分析研究水稻淀粉糊化中的霍夫米斯特离子
- DOI:
10.1016/j.foodhyd.2025.111265 - 发表时间:
2025-08-01 - 期刊:
- 影响因子:12.400
- 作者:
Weijie Qi;Yaxing Xie;Lina Sun;Zhimo Jiang;Jianjun Cheng;Qingfeng Ban - 通讯作者:
Qingfeng Ban
Biomaterials and Tissue Engineering Micropatterned cell co-cultures using layer-by-layer deposition of extracellular matrix components
生物材料和组织工程利用细胞外基质成分的逐层沉积进行微图案细胞共培养
- DOI:
- 发表时间:
2005 - 期刊:
- 影响因子:0
- 作者:
J. Fukuda;A. Khademhosseini;Judy Yeh;G. Eng;Jianjun Cheng;O. Farokhzad;R. Langer - 通讯作者:
R. Langer
Effects of carbonation on probiotic survivability, physicochemical, and sensory properties of milk-based symbiotic beverages.
碳酸化对乳共生饮料益生菌存活率、理化和感官特性的影响。
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:3.9
- 作者:
H. Walsh;Jianjun Cheng;M. Guo - 通讯作者:
M. Guo
Jianjun Cheng的其他文献
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{{ truncateString('Jianjun Cheng', 18)}}的其他基金
Hindered Urea Bond Based Dynamic Chemistry and Polymer Synthesis
基于位阻脲键的动态化学与聚合物合成
- 批准号:
1508710 - 财政年份:2015
- 资助金额:
$ 26万 - 项目类别:
Standard Grant
Poly(alpha-hydroxy acids) via Ring-Opening Polymerization of O-Carboxyanhydrides
通过 O-羧酸酐的开环聚合得到聚(α-羟基酸)
- 批准号:
1308485 - 财政年份:2013
- 资助金额:
$ 26万 - 项目类别:
Standard Grant
Synthesis and Studies of Water-Soluble, Alpha-Helical Polypeptide with Charged Side Chains
带电荷侧链的水溶性α螺旋多肽的合成与研究
- 批准号:
1153122 - 财政年份:2012
- 资助金额:
$ 26万 - 项目类别:
Standard Grant
CAREER: Development of Conjugated Polymer-Drug Nanoparticulate Delivery Vehicles
职业:共轭聚合物-药物纳米颗粒输送载体的开发
- 批准号:
0748834 - 财政年份:2008
- 资助金额:
$ 26万 - 项目类别:
Continuing Grant
Controlled Polymerization of Amino Acid N-Carboxyanhydrides
氨基酸 N-羧酸酐的受控聚合
- 批准号:
0809420 - 财政年份:2008
- 资助金额:
$ 26万 - 项目类别:
Continuing Grant
相似海外基金
Controlled Synthesis of Polypeptides from Non-Purified N-Carboxyanhydrides
由未纯化的 N-羧酸酐控制合成多肽
- 批准号:
1905097 - 财政年份:2020
- 资助金额:
$ 26万 - 项目类别:
Standard Grant
Photoredox Polymerization of O-Carboxyanhydrides for Functionalized Polyesters
O-羧酸酐光氧化还原聚合制备功能化聚酯
- 批准号:
1807911 - 财政年份:2018
- 资助金额:
$ 26万 - 项目类别:
Continuing Grant
Poly(alpha-hydroxy acids) via Ring-Opening Polymerization of O-Carboxyanhydrides
通过 O-羧酸酐的开环聚合得到聚(α-羟基酸)
- 批准号:
1308485 - 财政年份:2013
- 资助金额:
$ 26万 - 项目类别:
Standard Grant
Controlled Polymerization of Amino Acid N-Carboxyanhydrides
氨基酸 N-羧酸酐的受控聚合
- 批准号:
0809420 - 财政年份:2008
- 资助金额:
$ 26万 - 项目类别:
Continuing Grant