Collaborative Research: Dakota Bioprocessing Consortium (DakotaBioCon)

合作研究：达科他生物加工联盟 (DakotaBioCon)

• 批准号: 1330842
• 负责人: James Rice
• 金额: $ 300万
• 依托单位: South Dakota State University
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1330842&HistoricalAwards=false
• 关键词: Collaborative; Research; Dakota; Bioprocessing; Consortium

The Dakota Bioprocessing Consortium (DakotaBioCon) brings together researchers from four institutions in two neighboring states, North Dakota and South Dakota, with similar geographical, socio-economic and environmental diversity: North Dakota State University (NDSU), South Dakota State University (SDSU), University of North Dakota (UND) and South Dakota School of Mines & Technology (SDSMT). The vision of DakotaBioCon is through cutting-edge research and development to become a recognized intellectual leader in biomass bioprocessing that can help the region, nation and global society transition to a bio-based economy. The primary goal of DakotaBioCon is to establish a multi-state, multi-institution, multi-disciplinary, collaborative infrastructure to enable and facilitate the development of novel bioprocessing technologies for sustainable production of high-value chemicals and materials from renewable resources, with emphasis on lignin-derived products as economically viable substitutes for imported fossil-fuel based chemicals. DakotaBioCon achieves its goal of regional infrastructure development in the area of lignin bioprocessing through the accomplishment of several integrated objectives:1) Convert lignin into low molecular weight chemical fractions using a suite of novel processing methods, including high-temperature liquefaction and biodegradation of lignin, and analytical methods, (chromatography, spectrometry and chemical methods) to enable mass balance closure;2) Decipher the reaction mechanisms associated with the proposed lignin disassembly methods as a means to optimize and channel lignin fragmentation reaction pathways;3) Design process/purification schemes to convert precursor chemicals into valuable products;4) Develop new monomers/polymers and composites from lignin-derived aromatics/phenolics;5) Develop and upgrade the research and education infrastructure through joint collaborative activities that include sharing of data, knowledge, expertise, equipment, facilities, and educational programs.The impacts of DakotaBioCon are far-reaching, and extend beyond the award period. Bioprocessing of renewable resources addresses strategic national security priorities by reducing national dependence on imported oil and creates new jobs. To ensure continuation and long-term sustainability, DakotaBioCon leverages existing partnerships within UND's Sustainable Energy Research Initiative and Supporting Education (SUNRISE), SDSU's SunGrant Initiative, and SDSMT's Center for Bioprocessing Research and Development (CBRD) and future commercial intellectual property.Intellectual Merit:DakotaBioCon focuses on bioprocessing of lignin to renewable phenolics, aromatic chemicals and green polymers with potential uses as chemical and polymeric alternatives to petrochemicals. New knowledge and scientific contributions to the field of lignin bioprocessing are being generated. The intellectual merit of the proposed research approach is: 1) the potential for development of new, more cost-efficient and environmentally-friendly methods/agents for lignin depolymerization; 2) the potential for development of a suite of novel analytical methods enabling detailed product analysis; 3) the potential for deciphering the mechanistic aspects of lignin thermochemical and biological fragmentation to attain enhanced conversion rates and/or generate new lignin building-block precursors for industrial chemical processes; and 4) the potential for development of new, green materials with improved chemical and physical properties.Broader Impacts:DakotaBioCon infrastructure supports basic and applied research programs and offer expanded education, training and workforce development opportunities for a diverse cohort of K-12, undergraduate, and graduate students. It contributes to meeting national energy and economic security needs. These programs are leveraged to enhance collaboration, knowledge, and resource-sharing in the growing interdisciplinary field of renewable energy and materials. The education and workforce development strategy of DakotaBioCon are characterized by an interdisciplinary approach and a unique web of partnerships that helps advance these programs to the next level of performance and delivery. Research findings are widely disseminated to the scientific community and public through website, news media, radio, public databases, presentations at national and international meetings, and peer-reviewed publications in journals of international repute.

达科他生物处理联盟（DakotaBioCon）汇集了来自两个相邻州（北达科他州和南达科他州）的四个机构的研究人员，这些机构具有相似的地理，社会经济和环境多样性：北达科他州州立大学（NDSU），南达科他州州立大学（SDSU），北达科他州大学（UND）和南达科他州矿业技术学院（SDSMT）。DakotaBioCon的愿景是通过尖端的研究和开发，成为生物质生物加工领域公认的知识领导者，帮助地区，国家和全球社会向生物经济过渡。DakotaBioCon的主要目标是建立一个多州、多机构、多学科的协作基础设施，以实现和促进新型生物加工技术的开发，用于从可再生资源中可持续生产高价值化学品和材料，重点是木质素衍生产品作为进口化石燃料化学品的经济可行替代品。DakotaBioCon通过实现几个综合目标来实现其在木质素生物加工领域的区域基础设施发展目标：1）使用一套新的加工方法将木质素转化为低分子量化学馏分，包括木质素的高温液化和生物降解，以及分析方法，（色谱法、光谱法和化学方法），以实现质量平衡关闭; 2）破译与所提出的木质素分解方法相关的反应机制，作为优化和引导木质素裂解反应途径的手段; 3）设计工艺/纯化方案以将前体化学品转化为有价值的产品;4）从木质素衍生的芳烃/酚类化合物开发新的单体/聚合物和复合材料; 5）通过联合合作活动，包括共享数据，知识，专业知识，设备，设施和教育计划，发展和升级研究和教育基础设施。DakotaBioCon的影响是深远的，并延长到奖励期之后。可再生资源的生物加工通过减少国家对进口石油的依赖和创造新的就业机会，解决了国家安全的战略优先事项。为了确保持续和长期的可持续性，DakotaBioCon充分利用UND的可持续能源研究计划和支持教育（日出）、SDSU的SunGrant计划和SDSMT的生物加工研究与发展中心（CBRD）内的现有合作伙伴关系以及未来的商业知识产权。知识优势：DakotaBioCon专注于将木质素生物加工成可再生酚醛树脂、芳香族化学品和绿色聚合物，这些聚合物具有潜在的化学和聚合物替代石化产品的用途。木质素生物加工领域的新知识和科学贡献正在产生。提出的研究方法的智力价值是：1）开发新的，更具成本效益和环境友好的木质素解聚方法/试剂的潜力; 2）开发一套新的分析方法的潜力，使详细的产品分析; 3）破译木质素热化学和生物裂解的机制方面以获得提高的转化率的潜力，和/或或为工业化学过程产生新的木质素结构单元前体;以及4）开发具有改进化学和物理特性的新型绿色材料的潜力。更广泛的影响：DakotaBioCon基础设施支持基础和应用研究项目，并为K-12、本科生和研究生的多样化群体提供扩大的教育、培训和劳动力发展机会。它有助于满足国家能源和经济安全需求。这些计划被用来加强可再生能源和材料日益增长的跨学科领域的合作，知识和资源共享。DakotaBioCon的教育和劳动力发展战略的特点是跨学科的方法和独特的合作伙伴关系网络，有助于将这些计划推向下一个绩效和交付水平。研究结果通过网站、新闻媒体、广播、公共数据库、在国家和国际会议上的介绍以及在国际知名期刊上发表同行评审的出版物，向科学界和公众广泛传播。