EFRI-ODISSEI: Origami and Assembly Techniques for Human-Tissue-Engineering (OATH)

EFRI-ODISSEI：人体组织工程 (OATH) 的折纸和组装技术

• 批准号: 1332249
• 负责人: Carol Livermore
• 金额: $ 200万
• 依托单位: Northeastern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1332249&HistoricalAwards=false
• 关键词: EFRI; ODISSEI; Origami; Assembly; Techniques

The overall research objective of this project is to create assembly- and origami-based techniques for the generation of fully three-dimensional living tissues that are structured like natural tissues and include effective vascular networks. To accomplish this goal, the research first uses two-dimensional directed assembly to selectively locate multiple cell types in their proper locations on two-dimensional scaffold structures. The scaffolds are then origami-folded to convert the two-dimensional cell assemblies into three-dimensional structures that replicate the structure of natural tissues. This research addresses the three limitations to tissue engineering - tissue quality, tissue quantity, and speed of production - that have stood in the way of generating tissues for medical therapies. The project will also create new K-12 teacher training materials on origami in mathematics; involve high school students and teachers directly in the research; enable research opportunities for undergraduates from a diversity of backgrounds; and engage with high school students and the public through museum and high school level mathematics outreach. If successful, this project offers the potential to save lives through the creation of tissues rapidly and efficiently with an extremely high level of control over tissue structure. At present, the limited supply of donor organs leads to thousands of deaths every year. The improved engineering of human tissues has the potential to save lives directly, through the provision of transplants to supplement the supply of donor organs, as well as indirectly, by creating tissues for the screening of new medical therapies before human testing takes place. From an educational and societal perspective, the benefits include enhancement of grade school and high school mathematics education through wide distribution of teacher training materials; increased opportunities for public engagement with origami mathematics through museum exhibits; and broadened research engagement of high school students, undergraduates, and teachers, with a particular emphasis on those from underrepresented minority backgrounds or who serve predominantly underrepresented minority communities. This research project is jointly supported by the National Science Foundation and the US Air Force Office of Scientific Research.

该项目的总体研究目标是创建基于组装和折纸的技术，用于生成完全三维的活组织，其结构类似于天然组织，并包括有效的血管网络。为了实现这一目标，该研究首先使用二维定向组装来选择性地将多种细胞类型定位在二维支架结构上的适当位置。然后将支架折纸折叠以将二维细胞组装体转化为复制天然组织结构的三维结构。这项研究解决了组织工程的三个局限性-组织质量，组织数量和生产速度-这些都阻碍了医学治疗组织的产生。该项目还将创建新的K-12数学折纸教师培训材料;让高中学生和教师直接参与研究;为来自不同背景的本科生提供研究机会;并通过博物馆和高中数学外展活动与高中学生和公众接触。如果成功，该项目将提供通过快速有效地创建组织并对组织结构进行极高水平控制来挽救生命的潜力。目前，捐献器官的供应有限，每年导致数千人死亡。改进人体组织工程有可能通过提供移植以补充捐赠器官的供应而直接拯救生命，也有可能通过在人体试验之前制造用于筛选新的医学疗法的组织而间接拯救生命。从教育和社会的角度来看，其好处包括通过广泛分发教师培训材料加强小学和高中数学教育;通过博物馆展览增加公众参与折纸数学的机会;扩大了高中生、本科生和教师的研究参与度，特别强调那些来自代表性不足的少数群体背景或为代表性不足的少数群体社区服务的人。该研究项目由美国国家科学基金会和美国空军科学研究办公室共同支持。