CAREER: Manipulating Microcomponents for Self-Assembly-Based Manufacturing and Chromatography

职业：操纵微元件进行自组装制造和色谱分析

• 批准号: 0644245
• 负责人: Carol Livermore
• 金额: $ 40万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0644245&HistoricalAwards=false
• 关键词: CAREER; Manipulating; Microcomponents; Self; Assembly

ECCS-0644245Carol Livermore-Clifford, MITThis CAREER proposal focuses on a selective microcomponent manipulation process called templated assembly by selective removal (TASR), its applications for manufacturing complex microsystems by self-assembly, and its use for filtering and chromatography. The intellectual merit of this work lies in the creation and understanding of flexible, broadly-applicable micro and nanomanufacturing techniques based on TASR, and in the creation of the practical systems such as optically-based sensors that it enables. TASR simultaneously and selectively organizes diverse, small-scale (100 nanometer to 10 micron) components from fluid into shape- and size-matched holes in a substrate. The topography of the substrate is prepatterned, and the surface is coated to promote component-substrate adhesion. Selectivity is ensured by applying megahertz frequency ultrasonic excitation; the resulting quantitatively-describable, controllable fluid forces preferentially remove components from poorly-matched holes while leaving them in the well-matched holes in which they are more strongly attached. One key research topic is the selective placement of components of different shapes, materials, and hardnesses. Well-characterized experiments and quantitative analytic models will elucidate TASR's capabilities and limits. A second key research topic is the creation of economical template hardware to guide the selective manipulation process. The final major research topic is the application of the TASR approach to create functional systems. TASR offers extremely high selectivity based on differences in size and shape along with a rapid means of assembling systems of diverse components that are hard to create by traditional top-down techniques. The broader impacts of this work are in the integration of educational and research activities and in the broad dissemination of tools produced in the research. Educational activities include the creation of undergraduate laboratory curriculum pertaining to self-assembly, research opportunities for graduate and undergraduate students, and the creation, implementation, and dissemination of research-related materials for outreach to underrepresented high school students.

ECCS-0644245Carol Livermore-Clifford，麻省理工学院此职业提案重点关注称为选择性去除模板组装 (TASR) 的选择性微元件操作过程、其通过自组装制造复杂微系统的应用，以及其在过滤和色谱中的用途。 这项工作的智力价值在于创建和理解基于 TASR 的灵活、广泛适用的微米和纳米制造技术，以及创建实用系统，例如它所支持的基于光学的传感器。 TASR 同时选择性地将流体中的各种小尺寸（100 纳米至 10 微米）成分组织到基板上形状和尺寸匹配的孔中。 基板的形貌已预先图案化，并且表面经过涂层以促进元件与基板的粘合。 采用兆赫频率超声波激励，保证选择性；由此产生的可定量描述、可控的流体力优先将组件从不匹配的孔中移除，同时将它们留在匹配良好的孔中，从而使它们更牢固地附着在其中。一个关键的研究课题是不同形状、材料和硬度的组件的选择性放置。 充分表征的实验和定量分析模型将阐明 TASR 的功能和局限性。 第二个关键研究课题是创建经济的模板硬件来指导选择性操作过程。 最后一个主要研究课题是应用 TASR 方法来创建功能系统。 TASR 根据尺寸和形状的差异提供极高的选择性，并提供快速组装不同组件系统的方法，而传统的自上而下技术很难创建这些组件。这项工作的更广泛影响在于教育和研究活动的整合以及研究中产生的工具的广泛传播。 教育活动包括创建与自组装相关的本科生实验室课程、为研究生和本科生提供研究机会，以及创建、实施和传播与研究相关的材料以向代表性不足的高中生推广。