CAREER: Manipulating Microcomponents for Self-Assembly-Based Manufacturing and Chromatography

carol liver更多- clifford，麻省理工学院这份职业计划书的重点是一种被称为选择性去除模板组装（TASR）的选择性微组件操作过程，它在通过自组装制造复杂微系统中的应用，以及它在过滤和色谱中的应用。这项工作的智力价值在于基于TASR的灵活、广泛应用的微纳米制造技术的创造和理解，以及它所能实现的实用系统的创造，如基于光学的传感器。TASR同时有选择地将流体中的各种小尺寸（100纳米到10微米）组件组织成基材上形状和尺寸匹配的孔。对基板的地形进行预图案化，并对其表面进行涂覆以促进组件-基板的粘附。采用兆赫频率超声激励，保证了选择性；由此产生的可定量描述的、可控的流体力优先将组分从匹配不佳的孔中移除，而将它们留在匹配良好的孔中，这些孔中它们的附着强度更强。一个关键的研究课题是选择放置不同形状、材料和硬度的部件。充分表征的实验和定量分析模型将阐明TASR的能力和局限性。第二个重点研究课题是创建经济的模板硬件来指导选择性操作过程。最后的主要研究课题是应用TASR方法创建功能系统。TASR基于尺寸和形状的差异提供了极高的选择性，同时还具有快速组装各种组件系统的手段，这是传统自上而下的技术难以创建的。这项工作的更广泛影响在于将教育和研究活动结合起来，并广泛传播研究中产生的工具。教育活动包括创建与自组装相关的本科实验课程，为研究生和本科生提供研究机会，以及创建、实施和传播与研究相关的材料，以扩展到代表性不足的高中学生。

ECCS-0644245Carol Livermore-Clifford, MITThis CAREER proposal focuses on a selective microcomponent manipulation process called templated assembly by selective removal (TASR), its applications for manufacturing complex microsystems by self-assembly, and its use for filtering and chromatography. The intellectual merit of this work lies in the creation and understanding of flexible, broadly-applicable micro and nanomanufacturing techniques based on TASR, and in the creation of the practical systems such as optically-based sensors that it enables. TASR simultaneously and selectively organizes diverse, small-scale (100 nanometer to 10 micron) components from fluid into shape- and size-matched holes in a substrate. The topography of the substrate is prepatterned, and the surface is coated to promote component-substrate adhesion. Selectivity is ensured by applying megahertz frequency ultrasonic excitation; the resulting quantitatively-describable, controllable fluid forces preferentially remove components from poorly-matched holes while leaving them in the well-matched holes in which they are more strongly attached. One key research topic is the selective placement of components of different shapes, materials, and hardnesses. Well-characterized experiments and quantitative analytic models will elucidate TASR's capabilities and limits. A second key research topic is the creation of economical template hardware to guide the selective manipulation process. The final major research topic is the application of the TASR approach to create functional systems. TASR offers extremely high selectivity based on differences in size and shape along with a rapid means of assembling systems of diverse components that are hard to create by traditional top-down techniques. The broader impacts of this work are in the integration of educational and research activities and in the broad dissemination of tools produced in the research. Educational activities include the creation of undergraduate laboratory curriculum pertaining to self-assembly, research opportunities for graduate and undergraduate students, and the creation, implementation, and dissemination of research-related materials for outreach to underrepresented high school students.