I-Corps: Development of Bent DNA Molecules as Amplifying Sensors

I-Corps:开发弯曲 DNA 分子作为放大传感器

基本信息

  • 批准号:
    2129225
  • 负责人:
  • 金额:
    $ 5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-06-01 至 2023-05-31
  • 项目状态:
    已结题

项目摘要

The broader impact/commercial potential of this I-Corps project is the development of sensors to investigate DNA interactions with ions and small organic molecules, and the screening of DNA-targeting molecules as potential drugs. DNA is one of the most essential elements of life. The interactions of DNA with inorganic salts and small organic molecules are important for understanding various fundamental cellular processes in living systems, for deciphering the mechanisms of diseases and cancers related to DNA damage and repair, and for discovering, designing, and developing inhibitors and drugs to treat various diseases and cancers. The proposed sensor technology is designed to amplify, detect, and quantify the interactions of various molecules (e.g., metal ions, small organic molecules, and DNA-targeting drugs) with DNA. Although various techniques have been developed for investigating the interactions between DNA and other molecules, the current techniques suffer from various drawbacks, such as requiring expensive, sophisticated, and complex equipment, or lacking sensitivity. The development of this technology may benefit and has application in several market areas including life science research tools, analytical lab services, and the pharmaceutical industry.This I-Corps project is based on the development of nano-amplifiers/sensors based on bent DNA molecules for amplifying, detecting, and quantifying DNA interactions with other molecules. Current methods to measure and quantify DNA interactions have drawbacks and there is a need for easier, more sensitive, and more economic technologies. The proposed technology makes use of bent DNA molecules in the shape of archery bows that are under mechanical stress and more sensitive to the presence of ions, small organic molecules, and DNA-targeting drug molecules. The proposed design is based on self-assembled bent DNA amplifiers. Recent results have demonstrated that bent DNA amplifiers are able to amplify and detect the interactions between DNA and 14 different inorganic salts and small organic molecules, including one anti-cancer drug. This technology may enable life science research activities that were previously not possible or easy to carry out. The potential applications may include developing an assay for amplifying and detecting DNA interactions with various molecules and ions, enabling quantitative understanding of the mechanisms of DNA interactions with these molecules, detecting the accumulation of heavy ions in cells and tissues, and screening DNA-targeting molecules as potential drugs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这个I-Corps项目更广泛的影响/商业潜力是开发传感器来研究DNA与离子和小有机分子的相互作用,以及筛选DNA靶向分子作为潜在药物。DNA是生命最基本的元素之一。DNA与无机盐和有机小分子的相互作用对于理解生命系统中的各种基本细胞过程,对于破译与DNA损伤和修复相关的疾病和癌症的机制,以及对于发现,设计和开发治疗各种疾病和癌症的抑制剂和药物都很重要。 所提出的传感器技术被设计为放大、检测和量化各种分子(例如,金属离子、小有机分子和DNA靶向药物)与DNA的结合。尽管已经开发了各种技术来研究DNA与其他分子之间的相互作用,但目前的技术存在各种缺点,例如需要昂贵、精密和复杂的设备,或者缺乏灵敏度。 这项技术的发展可能会受益,并在几个市场领域,包括生命科学研究工具,分析实验室服务,和制药industry.This I-Corps项目是基于纳米放大器/传感器的发展为基础的弯曲DNA分子的扩增,检测和量化DNA与其他分子的相互作用。目前测量和量化DNA相互作用的方法存在缺陷,需要更容易、更灵敏和更经济的技术。这项技术利用了弓箭形状的弯曲DNA分子,这些分子处于机械应力下,对离子、小有机分子和DNA靶向药物分子的存在更敏感。所提出的设计是基于自组装弯曲DNA放大器。 最近的研究结果表明,弯曲DNA放大器能够放大和检测DNA与14种不同的无机盐和小有机分子之间的相互作用,其中包括一种抗癌药物。 这项技术可以使以前不可能或不容易进行的生命科学研究活动成为可能。 潜在的应用可以包括开发用于扩增和检测DNA与各种分子和离子的相互作用的测定,使得能够定量地理解DNA与这些分子的相互作用的机制,检测重离子在细胞和组织中的积累,筛选DNA-该奖项反映了NSF的法定使命,并被认为值得通过使用基金会的学术价值和更广泛的影响审查标准。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Yong Wang其他文献

Enhancing heat production by managing heat and water flow in confined geothermal aquifers
通过管理承压地热含水层中的热量和水流来提高产热能力
  • DOI:
    10.1016/j.renene.2019.03.147
  • 发表时间:
    2019-11
  • 期刊:
  • 影响因子:
    8.7
  • 作者:
    Zhenjiao Jiang;Tianfu Xu;Yong Wang
  • 通讯作者:
    Yong Wang
Propofol affects mouse embryonic fibroblast survival and proliferation in vitro via ATG5- and calcium-dependent regulation of autophagy
异丙酚通过 ATG5 和钙依赖性自噬调节影响体外小鼠胚胎成纤维细胞的存活和增殖
  • DOI:
    10.1038/s41401-019-0303-z
  • 发表时间:
    2019-10
  • 期刊:
  • 影响因子:
    8.2
  • 作者:
    Zhen-dong Xu;Yong Wang;Ge Liang;Zhi-qiang Liu;Wu-hua Ma;Charleen T Chu;Hua-feng Wei
  • 通讯作者:
    Hua-feng Wei
Numerical Investigation on Wave Drag Reduction by Laser Energy Deposition
激光能量沉积减阻波阻的数值研究
  • DOI:
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Xiaojing Yu;Hong Yan;Yong Wang
  • 通讯作者:
    Yong Wang
Retraction Note to: SELP genetic polymorphisms may contribute to the pathogenesis of coronary heart disease and myocardial infarction: a meta-analysis
撤回注释:SELP 基因多态性可能有助于冠心病和心肌梗死的发病机制:一项荟萃分析
  • DOI:
    10.1007/s11033-015-3888-4
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    2.8
  • 作者:
    Donghui Zhou;Yong Wang;Wei;Li;Qi Wang;M. Chi;Yuanzhe Jin
  • 通讯作者:
    Yuanzhe Jin
Clinical and Population Studies Deficient CD 4 CD 25 T Regulatory Cell Function in Patients With Abdominal Aortic Aneurysms
腹主动脉瘤患者 CD 4 CD 25 T 调节细胞功能缺陷的临床和人群研究
  • DOI:
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ming;Jian Zhang;Yong Wang;Shao;D. Böckler;Z. Duan;S. Xin
  • 通讯作者:
    S. Xin

Yong Wang的其他文献

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{{ truncateString('Yong Wang', 18)}}的其他基金

IIBR Instrumentation: Collaborative Research: Development of a Single-Biomolecule Detection Instrument via Digital Counting of Nanoparticles
IIBR Instrumentation:合作研究:通过纳米颗粒数字计数开发单生物分子检测仪器
  • 批准号:
    1911764
  • 财政年份:
    2019
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
REU Site in IoT Security
物联网安全领域的 REU 站点
  • 批准号:
    1852145
  • 财政年份:
    2019
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
Understanding the antimicrobial mechanism of metal nanoparticles using super resolution fluorescence microscopy
使用超分辨率荧光显微镜了解金属纳米颗粒的抗菌机制
  • 批准号:
    1826642
  • 财政年份:
    2018
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
Growth of Hybrid Polymeric Nanostructures for Enzyme-Free Amplified Protein Imaging
用于无酶放大蛋白质成像的混合聚合物纳米结构的生长
  • 批准号:
    1802953
  • 财政年份:
    2018
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
UKCRIC National Centre for Infrastructure Materials - Extreme Loading Facilities
UKCRIC 国家基础设施材料中心 - 极限负载设施
  • 批准号:
    EP/P017061/1
  • 财政年份:
    2017
  • 资助金额:
    $ 5万
  • 项目类别:
    Research Grant
Structural and Fire Resistance of a Reusable Steel/Concrete Composite Floor System
可重复使用的钢/混凝土复合地板系统的结构和防火性能
  • 批准号:
    EP/N01135X/1
  • 财政年份:
    2016
  • 资助金额:
    $ 5万
  • 项目类别:
    Research Grant
CAREER: Creation of Complex Biomimetic Materials via Molecular Recognition
职业:通过分子识别创建复杂的仿生材料
  • 批准号:
    1332351
  • 财政年份:
    2013
  • 资助金额:
    $ 5万
  • 项目类别:
    Continuing Grant
Reversible Cell Capture and Release for Cell Separation
用于细胞分离的可逆细胞捕获和释放
  • 批准号:
    1340173
  • 财政年份:
    2013
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
MRI: Acquisition of Equipment to Establish Mobile Testing Infrastructure for Bring Your Own Device Research and Education
MRI:采购设备以建立移动测试基础设施,以便自带设备进行研究和教育
  • 批准号:
    1337529
  • 财政年份:
    2013
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
Controlling Protein Release via Intermolecular Hybridization
通过分子间杂交控制蛋白质释放
  • 批准号:
    1342893
  • 财政年份:
    2013
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant

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水稻边界发育缺陷突变体abnormal boundary development(abd)的基因克隆与功能分析
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使用弯曲晶体通道的光束处理技术的开发
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    17K05483
  • 财政年份:
    2017
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扩频法渗透探伤弯管流精确流量测量系统的研制
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用于 X 射线成像偏振测量的弯曲硅晶体的开发
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