MRI: Acquisition of a High Sensitivity X-Detect NMR Instrument

利用由化学研究仪器和设施(CRIF)计划共同资助的重大研究仪器计划授予的这一奖项，凯斯西储大学的Gregory Tochtrop教授和他的同事Blanton Tolbert将获得一台配备液氮冷却宽带X探测探头和自动采样系统的500 MHz核磁共振波谱仪。该建议旨在加强各级的研究和教育，特别是在下列领域：(A)研究脂质过氧化产物的分解代谢去向；(B)核磁共振检测病毒复制中涉及的RNA结构和蛋白质-RNA接触；(C)机械增强聚合物的研究；(D)基于有机共轭聚合物和分子的先进功能材料；(D)蛋白质的稳定性、结构和动力学；(E)互锁聚合物体系；(F)在信号转导途径中酶被激活的机制；(G)共轭分子和聚合物的表征；和(H)人类胰岛素的含氟芳香族类似物的设计和表征。核磁共振波谱是化学家可用于阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为化学、生物、聚合物科学与工程、化学工程和生物医学工程系学生教学和研究不可或缺的一部分。该仪器将加强大克利夫兰科学界的研究和教学能力，为非现场用户提供基于网络的时间表和启用网络的数据传输/处理。

With this award from the Major Research Instrumentation Program that is co-funded by the Chemistry Research Instrumentation and Facilities (CRIF) Program, Professor Gregory Tochtrop from Case Western Reserve and colleague Blanton Tolbert will acquire a 500 MHz NMR spectrometer equipped with a liquid-nitrogen cooled broadband X-detect probe and an automated sampling system. The proposal is aimed at enhancing research and education at all levels, especially in areas such as (a) studies of the catabolic fate of lipid peroxidation products; (b) NMR detection of RNA structures and protein-RNA contacts involved in viral replication; (c) studies of mechanically enhanced polymers; (d) advanced functional materials based upon organic conjugated polymers and molecules; (d) protein stability, structure, and dynamics; (e) interlocked polymeric architectures; (f) mechanisms by which enzymes are activated during signal transduction pathways; (g) characterization of conjugated molecules and polymers; and (h) design and characterization of fluoro-aromatic analogues of human insulin.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research of students in the departments of Chemistry, Biology, Polymer Science & Engineering, Chemical Engineering and Biomedical Engineering. The instrument will enhance the research and teaching capabilities of the greater Cleveland scientific community with web-based scheduling and cyber-enabled data delivery/processing for off-site users.