MRI: Acquisition of A High-sensitivity Electrospray Ionization Mass Spectrometer for Research and Education at the University of Texas at Dallas

MRI：德克萨斯大学达拉斯分校购买高灵敏度电喷雾电离质谱仪用于研究和教育

• 批准号: 2018188
• 负责人: Jie Zheng
• 金额: $ 24.31万
• 依托单位: University of Texas at Dallas
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2018188&HistoricalAwards=false
• 关键词: MRI; Acquisition; sensitivity; Electrospray; Ionization

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The University of Texas Dallas is acquiring an ultra-performance, electrospray ionization, mass spectrometer (UP-ESI-MS) to support Professor Jie Zheng and colleagues Jeremiah Gassensmith, Xianming Dai, Sheena D'Arcy and Yanping Qin. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species in complex samples. In the electrospray technique a high voltage is applied to a liquid to create an aerosol. This is useful to produce ions from large molecules by avoiding the propensity of macromolecules to fragment when ionized. The acquisition strengthens the research infrastructure at the university and regional area. The instrument broadens participation by involving diverse students with this modern analytical technique. It is also used in outreach activities involving students and faculty from the University of Texas at Arlington, the University of North Texas, and other activities involving local high-school students.The award of the mass spectrometer is aimed at enhancing research and education at all levels. It especially impacts the discovery of atomically precise gold nanoclusters that can be used to unravel nano-bio interactions in the sub-nanometer regime and the optimization of wetting and adhesion in surface-chemistry. The instrumentation is also used for developing methodology for the synthesis and assembly of symmetric aromatic building blocks and for developing bottom-up proteomics for self-assembling, self-healing electronics. In addition, it benefits studies of non-covalent transition metal-protein complexes and the development of activity-based imaging and proteomic tools for biological sulfurylation. The mass spectrometer is also used to develop bottom-up and top-down hydrogen-deuterium exchange of protein complexes and to design small organic molecules to inhibit protein-protein interactions. The ESI spectrometer is also employed in studies developing methodologies for selective carbon–hydrogen bond functionalization of aromatic and aliphatic molecules and for characterizing synthesized natural product derivatives which could eventually improve manufacturing processes.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划支持。德克萨斯大学达拉斯分校正在购买一台超性能电喷雾电离质谱仪（UP-ESI-MS），以支持Jie Zheng教授及其同事Jeremiah Gassensmith、Xianming Dai、Sheena D 'Arcy和Yanping Qin。一般来说，质谱（MS）是用于识别和表征复杂样品中少量化学物质的关键分析方法之一。在电喷雾技术中，将高电压施加到液体以产生气溶胶。这对于通过避免大分子在电离时碎裂的倾向而从大分子产生离子是有用的。此次收购加强了大学和地区的研究基础设施。该仪器通过让不同的学生参与这种现代分析技术来扩大参与。它也被用于涉及来自德克萨斯大学阿灵顿分校、北德克萨斯大学的学生和教师的外联活动，以及涉及当地高中生的其他活动。它特别影响了原子级精确的金纳米团簇的发现，这些纳米团簇可用于解开亚纳米范围内的纳米生物相互作用以及表面化学中润湿和粘附的优化。该仪器还用于开发对称芳香族结构单元的合成和组装方法，以及开发自下而上的蛋白质组学，用于自组装，自修复电子产品。此外，它有利于非共价过渡金属-蛋白质复合物的研究和生物磺酰化的基于活性的成像和蛋白质组学工具的开发。质谱仪还用于开发蛋白质复合物的自下而上和自上而下的氢-氘交换，并设计小有机分子以抑制蛋白质-蛋白质相互作用。ESI光谱仪还用于芳香族和脂肪族分子的选择性碳-氢键功能化方法的研究，以及用于表征合成天然产物衍生物的研究，这些衍生物最终可以改善制造工艺。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Crosstalk between Hepatic Glutathione Efflux and Tumor Targeting Efficiency of Indocyanine Green‐Conjugated Gold Nanoparticles

肝脏谷胱甘肽流出与吲哚菁绿-共轭金纳米粒子的肿瘤靶向效率之间的串扰

• DOI: 10.1002/anie.202308909
• 发表时间: 2023
• 期刊: Angewandte Chemie International Edition
• 作者: Huang, Yingyu;Xiao, Wei;Ahrari, Samira;Yu, Mengxiao;Zheng, Jie
• 通讯作者: Zheng, Jie

Sustainable icephobicity on durable quasi-liquid surface

• DOI: 10.1016/j.cej.2021.133475
• 发表时间: 2021-11
• 期刊: Chemical Engineering Journal
• 影响因子: 15.1
• 作者: Jyotirmoyee Sarma;Lei Zhang;Zongqi Guo;X. Dai

Proximal tubules eliminate endocytosed gold nanoparticles through an organelle-extrusion-mediated self-renewal mechanism

• DOI: 10.1038/s41565-023-01366-7
• 发表时间: 2023-04-17
• 期刊: NATURE NANOTECHNOLOGY
• 影响因子: 38.3
• 作者: Huang, Yingyu;Yu, Mengxiao;Zheng, Jie
• 通讯作者: Zheng, Jie