MRI: Acquisition of High-Sensitivity, Solids Capable 400 MHz NMR for Research and Undergraduate Training at the University of Colorado at Denver

MRI：获取高灵敏度、固体能力 400 MHz NMR，用于丹佛科罗拉多大学的研究和本科生培训

• 批准号: 1726947
• 负责人: Scott Reed
• 金额: $ 28.98万
• 依托单位: University of Colorado at Denver-Downtown Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2020-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1726947&HistoricalAwards=false
• 关键词: MRI; Acquisition; Sensitivity; Solids; Capable

This award is supported by the Major Research Instrumentation (MRI) and the Chemistry Research Instrumentation (CRIF) Programs. Professor Scott Reed from University of Colorado Denver-Downtown Campus and colleague Liliya Vugmeyster have acquired a 400 MHz nuclear magnetic resonance (NMR) spectrometer with solid state capabilities. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance. In general, NMR spectroscopy is one of the most powerful tools available to chemists for studying the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the changes in interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is important to chemists who are carrying out frontier research. The results from these NMR studies have an impact in synthetic organic/inorganic chemistry, materials chemistry, forensics and biochemistry. This instrument is an integral part of teaching as well as research performed by undergraduate students via independent student research and traditional academic coursework as well as researchers and master's students. The spectrometer is used by several programs that cater to underrepresented minority populations. Examples are Colorado Undergraduate Summer Program (CUSP), Graduate Experiences for Multicultural Students (GEMS), Building Research Achievement in Neuroscience (BRAiN), Summer Undergraduate Research Fellowship, LabCoats, Research Initiative for Scientific Enhancement (RISE), Maximizing Access to Research Careers (MARC U-STAR), Student Cancer Research Fellowship and Summer Undergraduate Minority Mentoring in Translational Science (SUMMiT).This NMR spectrometer enhances research and education at all levels. It may impact research efforts on the preparation of photo-releasable lipid probes, studies of structure-function relationships of modified RNA, and exploration of near-infrared self-illuminating nanoparticles for in vivo optical imaging of tumors. The instrumentation is also used for studying structural mechanisms of calcium inhibited C2 domains, exploring the role of interfacial interactions in the survival of unfrozen water in Antartic soils, and studying the mechanistic nature of protein dynamics transitions. The spectrometer benefits investigations on the effects of lipid interactions on internal dynamics of amyloid-beta fibrils, on phase transitions in liquid-crystalline elastomers, and on applications of solid state 14-nitrogen and 17-oxygen NMR to natural organic matter.

该奖项由主要研究仪器(MRI)和化学研究仪器(CRIF)项目支持。科罗拉多大学丹佛市中心校区的Scott Reed教授和同事Liliya Vugmeyster获得了一台具有固态功能的400 MHz核磁共振(核磁共振)光谱仪。这种光谱仪允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域。总体而言，核磁共振波谱是化学家研究分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体状态下相互作用的变化。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是很重要的。这些核磁共振研究的结果对合成有机/无机化学、材料化学、法医学和生物化学产生了影响。该仪器是本科生通过独立的学生研究和传统的学术课程以及研究人员和硕士学生进行的教学和研究的组成部分。有几个项目使用了这种光谱仪，这些项目迎合了少数族裔人口的需求。例如科罗拉多州本科生暑期计划(CUSP)、多文化学生研究生体验计划(GEMS)、建立神经科学研究成就(BRAN)、暑期本科生研究奖学金、LABCOAT、科学增强研究计划(RISE)、最大限度地获得研究职业机会(MARC U-STAR)、学生癌症研究奖学金和翻译科学本科生少数族裔暑期辅导(MOMIT)。这款核磁共振光谱仪增强了所有级别的研究和教育。这可能会影响到光释放脂质探针的制备，修饰RNA的结构-功能关系的研究，以及用于体内肿瘤光学成像的近红外自发光纳米颗粒的探索。该仪器还用于研究钙抑制C2结构域的结构机制，探索界面相互作用在南极土壤中未冻水生存中的作用，以及研究蛋白质动力学转变的机制性质。该光谱仪有助于研究脂质相互作用对淀粉样β纤维内部动力学的影响，对液晶弹性体相变的影响，以及固体14-氮和17-氧核磁共振在天然有机物中的应用。

项目成果

A Semester-Long, Organic Chemistry Laboratory Structured around Unknown Analysis and Resynthesis as a Bridge to Guided-Inquiry

一个为期一个学期的有机化学实验室，围绕未知分析和重新合成构建，作为引导探究的桥梁

• DOI: 10.1021/acs.jchemed.9b01037
• 发表时间: 2020
• 期刊: Journal of Chemical Education
• 影响因子: 3
• 作者: Kovacevic, Tanja;Skinner, Austin;Fisk, John D.;Fishback, Vanessa;Reed, Scott M.
• 通讯作者: Reed, Scott M.