Carbon Nanotube Based Nanofluidic Device for Biological Sensing
用于生物传感的碳纳米管纳米流体装置
基本信息
- 批准号:1334417
- 负责人:
- 金额:$ 38.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-01 至 2018-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The objective of this award is to develop and test a novel nanofluidic-nanoelectronic device with high specificity and sensitivity for biological sensing applications. To exploit the recently discovered nanofluidic advantages of carbon nanotube (CNT) nanochannel, nanofluidic devices based on high quality horizontally aligned single-walled CNT (SWCNT) arrays will first be fabricated. Then, the electrokinetic motion of analytes passing through the interior of CNT arrays will be characterized and controlled. Subsequently, practical approaches will be developed in these CNT nanofluidic devices to utilize several CNT based electrical sensing methods, including field effect transistor (FET), electrochemical sensing and capacitive charge sensing methods. Fundamental understandings of these sensing methods when they are incorporated into nanofluidic devices will be developed and different sensing methods will be combined together to achieve multimode sensing. Finally, the biosensor performance will be evaluated through the detection of secreted small molecules from individual living cells in real time. If successful, this highly interdisciplinary research will develop new ways to integrate nanofluidics and nanoelectronics into one device. The knowledge and methods obtained from this project can be applied to other metallic or semiconducting nanotubes and nanopores. This project will lead to a new type of all-electrical biosensor, which will be ultrasensitive, highly selective, portable, cheap, requiring a low sample and power consumption. A new class of biosensor for single living cell sensing will be developed. The developed biosensor is also potentially applicable to a wide variety of areas: clinic diagnostics, environment protection and preservation, health improvement, national defense and bioterrorism prevention.
该奖项的目标是开发和测试一种具有高特异性和灵敏度的新型纳米流体-纳米电子器件,用于生物传感应用。为了充分利用碳纳米管(CNT)纳米通道在纳米流控方面的优势,将首先制备基于高质量水平排列单壁碳纳米管(SWCNT)阵列的纳米流控器件。然后,分析物通过碳纳米管阵列内部的电动力学运动将被表征和控制。随后,将在这些碳纳米管纳米流体器件中开发实用方法,以利用几种基于碳纳米管的电传感方法,包括场效应晶体管(FET)、电化学传感和电容电荷传感方法。当这些传感方法被纳入纳米流体器件时,将发展对这些传感方法的基本理解,并将不同的传感方法结合在一起实现多模传感。最后,将通过实时检测单个活细胞分泌的小分子来评估生物传感器的性能。如果成功,这项高度跨学科的研究将开发出将纳米流体学和纳米电子学集成到一个设备中的新方法。本项目所获得的知识和方法可以应用于其他金属或半导体纳米管和纳米孔。该项目将导致一种新型的全电生物传感器,它将具有超灵敏、高选择性、便携、廉价、低样本和低功耗的特点。将开发一种用于单个活细胞传感的新型生物传感器。开发的生物传感器还可以广泛应用于临床诊断,环境保护和保存,健康改善,国防和生物恐怖主义预防等领域。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jin He其他文献
Hepatocytic precursor (stem-like) WB-F344 cells reduce tumorigenicity of hepatoma CBRH-7919 cells via TGF-beta/Smad pathway.
肝细胞前体(干细胞样)WB-F344 细胞通过 TGF-β/Smad 途径降低肝癌 CBRH-7919 细胞的致瘤性。
- DOI:
- 发表时间:
2010 - 期刊:
- 影响因子:0
- 作者:
Wei;Yi;Jia Guo;Yu;Xiao;Hui;Yi Xu;Hui;Jin He;Hong - 通讯作者:
Hong
Variation in Photodynamic Efficacy during the Cellular Uptake of Two Phthalocyanine Photosensitizers
两种酞菁光敏剂细胞摄取过程中光动力功效的变化
- DOI:
- 发表时间:
1998 - 期刊:
- 影响因子:3.3
- 作者:
Jin He;M. Horng;J. T. Deahl;N. Oleinick;H. H. Evans - 通讯作者:
H. H. Evans
Polynunomial Effective Channel Mobility Based Above-Threshold Current Model for Undoped Polycrystalline-Silicon Thin-Film Transistors Consistent With Pao-Sah Model
基于多项式有效沟道迁移率的与 Pao-Sah 模型一致的未掺杂多晶硅薄膜晶体管阈值以上电流模型
- DOI:
- 发表时间:
2012 - 期刊:
- 影响因子:3.1
- 作者:
Hongyu He;Xueren Zheng;Jin He;Mansun Chan - 通讯作者:
Mansun Chan
Micro-Strip Line 90 degrees Phase Shifter with Double Ground Slots for D-Band Applications
适用于 D 频段应用的具有双接地槽的微带线 90 度移相器
- DOI:
10.1142/s021812661850192x - 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
Jiang Luo;Jin He;Pengwei Chen;Hao Wang;Sheng Chang;Qijun Huang;Xurui Mao;Yueping Zhang - 通讯作者:
Yueping Zhang
The distributed temperature abatement by the phase changing materials for battery in electric tools and its influence on aging
电动工具电池相变材料的分布式降温及其对老化的影响
- DOI:
10.1016/j.seta.2022.102199 - 发表时间:
2022 - 期刊:
- 影响因子:8
- 作者:
Ruifei Ma;Jin He;Xueliang Fan;Yaoqiu Qian;Yelin Deng - 通讯作者:
Yelin Deng
Jin He的其他文献
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{{ truncateString('Jin He', 18)}}的其他基金
CAREER: Investigate 3D Extracellular Potential Distribution at Single Cell Level
职业:研究单细胞水平的 3D 细胞外电位分布
- 批准号:
1454544 - 财政年份:2015
- 资助金额:
$ 38.5万 - 项目类别:
Standard Grant
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