Complex Emergent Behaviors Arising from Simple Mechanically-Mediated Cell-Matrix Interactions

简单的机械介导的细胞-基质相互作用引起的复杂的突发行为

• 批准号: 1334757
• 负责人: Keith Gooch
• 金额: $ 28.03万
• 依托单位: Ohio State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1334757&HistoricalAwards=false
• 关键词: Complex; Emergent; Behaviors; Arising; Simple

The research objective of this award is to develop, validate, and utilize a computer model of cell-matrix interactions. The cell-matrix interactions are an important component a number of important biological processes including growth, development, cell migration, tumor metastasis, wound healing and tissue regeneration. Previous models of cell-matrix interactions have failed to capture the dynamic nature of these interactions and have only given static snapshots of what experiments reveal to be a constantly changing process. Agent-based models, a simulation technique well suited for dynamic processes, will be employed. The model will be validated against experimental data consisting of the shape and position of cells and extracellular matrix fibers. Once validated, the model can be used to gain insight into processes that cannot be explored directly using experiments. If successful, these studies would add significantly to the field's understanding of cell-matrix interactions, including the basic underlying biomechanical rules that work together to give rise to the observed biological behaviors. The work directed towards the completion of the scientific aims will provide the basis for extensive laboratory, project and lecture-based learning opportunities for high school, undergraduate and graduate students. An important component of such work will be incorporating agent-based modeling ongoing work with the Ohio Supercomputing Centers summer program for high school students and initiating a new collaboration with the Math and Science Program at The Ohio State University's African American and African Studies Community Extension Center.

该奖项的研究目标是开发，验证和利用细胞-基质相互作用的计算机模型。细胞-基质相互作用是许多重要生物学过程的重要组成部分，包括生长、发育、细胞迁移、肿瘤转移、伤口愈合和组织再生。以前的细胞-基质相互作用模型未能捕捉到这些相互作用的动态本质，只能给出实验揭示的不断变化的过程的静态快照。将采用基于代理的模型，这是一种非常适合于动态过程的模拟技术。该模型将验证对实验数据组成的细胞和细胞外基质纤维的形状和位置。一旦得到验证，该模型可用于深入了解无法直接使用实验探索的过程。 如果成功，这些研究将大大增加该领域对细胞-基质相互作用的理解，包括共同作用产生所观察到的生物行为的基本生物力学规则。针对科学目标的完成工作将为高中，本科和研究生提供广泛的实验室，项目和基于讲座的学习机会的基础。此类工作的一个重要组成部分将是将基于代理的建模与俄亥俄州超级计算中心针对高中生的夏季项目进行的工作结合起来，并与俄亥俄州州立大学的数学和科学项目发起新的合作。非裔美国人和非洲研究社区推广中心。