MRI: Acquisition of a Small Molecule Single Crystal X-ray Diffractometer for Research and Education Across Montana

由化学研究仪器和设施（CRIF）项目共同资助的主要研究仪器项目，蒙大拿大学的Orion Berryman教授和他的同事Tom Livingstone、Robert Szilagyi、Edward Rosenberg和Charles Thompson将获得一台单晶x射线衍射仪。该提案旨在加强各级的研究和教育，特别是在以下领域：(a)卤素键合有机催化剂的开发；(b)发光二亚胺钌配合物的固态结构；(c)确定谷氨酸转运蛋白的空间尺寸和关键结合基序的分子尺度的发展；(d) 3族金属的不对称催化和阳离子环化；(e)发展含异恶唑候选药物的结构活性关系；金属酶和有机金属催化剂的电子和几何结构。x射线衍射仪可以精确测量分子的完整三维结构，包括键距和角度，并提供有关分子相对于邻近分子的空间排列的准确信息。这里描述的研究将影响许多领域，包括有机和无机化学，材料化学和生物化学。这种乐器将成为教学、研究和研究培训的一个组成部分，并将有助于蒙大拿州大学和蒙大拿州立大学的学生，包括来自美洲原住民背景的学生以及高中生和部落学院的学生。

With this award from the Major Research Instrumentation Program that is co-funded by the Chemistry Research Instrumentation and Facilities (CRIF) Program, Professor Orion Berryman from the University of Montana and colleagues Tom Livingstone, Robert Szilagyi, Edward Rosenberg and Charles Thompson will acquire a single crystal X-ray diffractometer. The proposal is aimed at enhancing research and education at all levels, especially in areas such as (a) development of organocatalysts with halogen bonding; (b) solid-state structures of luminescent ruthenium diimine complexes; (c) development of molecular yardsticks to determine the spatial dimensions and key binding motifs of glutamate transporter proteins; (d) asymmetric catalysis of Group 3 metals and cationic cyclizations; (e) development of structure activity relationships for isoxazole containing drug candidates; and (f) electronic and geometric structures of metalloenzymatic and organometallic catalysts.An X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here will impact a number of areas, including organic and inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research and research training and will contribute to educate students both at the University of Montana and Montana State University including those from a Native American background as well as high school students and those at a tribal college.