MRI: Acquisition of a Small Molecule Single Crystal X-ray Diffractometer for Research and Education Across Montana

MRI：购买小分子单晶 X 射线衍射仪，用于蒙大拿州的研究和教育

• 批准号: 1337908
• 负责人: Orion Berryman
• 金额: $ 26.5万
• 依托单位: University of Montana
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1337908&HistoricalAwards=false
• 关键词: MRI; Acquisition; Small; Molecule; Single

With this award from the Major Research Instrumentation Program that is co-funded by the Chemistry Research Instrumentation and Facilities (CRIF) Program, Professor Orion Berryman from the University of Montana and colleagues Tom Livingstone, Robert Szilagyi, Edward Rosenberg and Charles Thompson will acquire a single crystal X-ray diffractometer. The proposal is aimed at enhancing research and education at all levels, especially in areas such as (a) development of organocatalysts with halogen bonding; (b) solid-state structures of luminescent ruthenium diimine complexes; (c) development of molecular yardsticks to determine the spatial dimensions and key binding motifs of glutamate transporter proteins; (d) asymmetric catalysis of Group 3 metals and cationic cyclizations; (e) development of structure activity relationships for isoxazole containing drug candidates; and (f) electronic and geometric structures of metalloenzymatic and organometallic catalysts.An X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here will impact a number of areas, including organic and inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research and research training and will contribute to educate students both at the University of Montana and Montana State University including those from a Native American background as well as high school students and those at a tribal college.

利用化学研究仪器和设施(CRIF)计划共同资助的重大研究仪器计划颁发的这一奖项，蒙大拿大学的Orion Berryman教授及其同事Tom Livingstone、Robert Szilagyi、Edward Rosenberg和Charles Thompson将获得单晶X射线衍射仪。该建议旨在加强各级的研究和教育，特别是在下列领域：(A)开发具有卤素键合的有机催化剂；(B)发光Ru二亚胺配合物的固态结构；(C)开发分子标尺以确定谷氨酸转运蛋白的空间尺寸和关键结合基序；(D)第3族金属的不对称催化和阳离子环化；(E)开发含异恶唑的候选药物的结构活性关系；和(F)金属酶和有机金属催化剂的电子和几何结构。X射线衍射仪可以准确和精确地测量分子的全部三维结构，包括键距离和角度，并提供关于分子相对于邻近分子的空间排列的准确信息。这里描述的研究将影响许多领域，包括有机化学和无机化学、材料化学和生物化学。这一工具将是教学以及研究和研究培训的组成部分，并将有助于蒙大拿大学和蒙大拿州立大学的学生，包括美洲土著人背景的学生以及高中生和部落大学的学生。