I-Corps: An enzymatic method for eradicating biofilm and multidrug resistant bacterial infections

I-Corps：一种消除生物膜和多重耐药细菌感染的酶法

• 批准号: 1340277
• 负责人: Chuanwu Xi
• 金额: $ 5万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1340277&HistoricalAwards=false
• 关键词: Corps; enzymatic; method; eradicating; biofilm

This technology is based on research findings that an enzyme treatment can prevent biofilm formation and re-sensitize multidrug resistant pathogens (including both gram-negative and positive bacteria) to antibiotic treatment. Both in vitro and animal model experiments have been successfully completed and demonstrated the efficacy of this technology. The enzyme can potentially be used to alone or as an adjuvant to improve the efficacy of existing and approved antibiotics to eradicate multidrug resistance infections, which in many cases are considered to be non-treatable diseases. Biofilm-related infections and the occurrence of multidrug resistance is a serious worldwide public health problem. In the US alone, roughly 2 million people acquire bacterial infections in the hospital which leads to 99,000 deaths annually. The initial target application is the topical application for wound infections and surgical site infections. Combinatorial the enzyme and antibiotic treatment could improve and the way flesh wounds and bacterial infections are treated in the clinic. The technology can also be applied to nosocomial pneumonia, bacteremia and sepsis, Infections in cystic fibrosis, catheter-associated bacteriuria, etc. especially when the last line of antibiotics is not effective.

该技术基于研究发现，即酶处理可以防止生物膜形成，并使多药耐药病原体（包括革兰氏阴性和阳性细菌）对抗生素治疗重新敏感。体外和动物模型实验均已成功完成，并证明了该技术的有效性。这种酶可以单独使用或作为佐剂，以提高现有和批准的抗生素的疗效，从而根除多重耐药感染，在许多情况下，这种感染被认为是不可治疗的疾病。生物被膜相关感染和多重耐药性的发生是一个严重的全球性公共卫生问题。仅在美国，每年就有大约200万人在医院感染细菌，导致99，000人死亡。初始目标应用是伤口感染和手术部位感染的局部应用。酶和抗生素的联合治疗可以改善临床上处理皮肤伤口和细菌感染的方式。该技术还可应用于医院获得性肺炎、菌血症和败血症、囊性纤维化感染、导管相关菌尿等，特别是当最后一种抗生素无效时。