INSPIRE Track 1: Intrinsic Oscillations in Supramolecular Assemblies: Novel Ultra-High Sensitivity Protein and Virus Detection

INSPIRE 轨道 1：超分子组装体中的固有振荡：新型超高灵敏度蛋白质和病毒检测

• 批准号: 1344263
• 负责人: Elliott Brown
• 金额: $ 62.55万
• 依托单位: Wright State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1344263&HistoricalAwards=false
• 关键词: INSPIRE; Track; Intrinsic; Oscillations; Supramolecular

Overview: This INSPIRE award is partially funded by the Electronics, Photonics, and Magnetics Devices Program in the Division of Electrical, Communications and Cyber Systems in the Directorate for Engineering; and the Chemical Structure, Dynamics and Mechanisms program in the Division of Chemistry in the Directorate for Mathematical and Physical Sciences. Objective: Recently predicted autonomous oscillations in virus-like particles are investigated via simulation and experiment. Types of biological systems displaying such oscillations will be identified, and implications for pure and applied sciences drawn. Novel multiscale theoretical methods will be developed for the simulations, and nanofluidic coupling structures will be fabricated for high-sensitivity high-resolution GHz-to-THz detection of the oscillations.Intellectual merit: At the boundary between the microscopic and macroscopic worlds, sustained autonomous structural oscillations in nanostructures will be investigated. As the phenomena of interest involve both long- and short-temporal scale processes, novel concepts in multiscale theory will be developed. Coarse-grained variables will be coevolved with the positions and momenta of the N atoms using Trotter factorization with attendant accuracy control. Innovations include: (a) discovery of sustained autonomous oscillations in equilibrium mesoscopic systems; (b) methods in multiscale theory; (c) biosample presentation and spectroscopic identification of autonomous oscillations in virus-like particles; (d) methods for viral threat detection and nanomedical design; and (e) autonomously oscillating molecular circuit elements. Broader impacts: A successful investigation will revolutionize structural biochemistry and the electromagnetics of biological systems, and could provide a radical change in viral sensing for threat-detection and human health. Methods for computer-aided design of nanostructured materials for molecular electronics and nanomedical systems are developed. Opportunities for under-represented groups in STEM education are created.Why Inspire?Electrical engineers understand the importance of nondissipative oscillatory circuit elements. Chemists and physicists have expertise in multiscale theory. Biologists understand the responses of virus-like particles. Few scientists appreciate all these topics.

概述：该INSPIRE奖部分由工程局电气、通信和网络系统部门的电子、光子学和磁性设备项目资助；以及数学和物理科学理事会化学系的化学结构、动力学和机制项目。目的：通过模拟和实验对最近预测的病毒样颗粒的自主振荡进行研究。将识别显示这种振荡的生物系统类型，并绘制对纯科学和应用科学的影响。研究人员将开发新的多尺度理论模拟方法，并制作纳米流体耦合结构，用于高灵敏度、高分辨率的ghz - thz振荡检测。智力优势：在微观和宏观世界之间的边界，纳米结构中持续的自主结构振荡将被研究。由于感兴趣的现象涉及长时间和短时间尺度过程，因此将发展出多尺度理论中的新概念。粗粒度变量将与N原子的位置和动量共同演化，使用Trotter分解并附带精度控制。创新包括：(a)平衡介观系统中持续自主振荡的发现；(b)多尺度理论方法；(c)病毒样颗粒的生物样品展示和自主振荡的光谱鉴定；(d)病毒威胁检测和纳米医学设计方法；(e)自主振荡分子电路元件。更广泛的影响：一项成功的研究将彻底改变生物系统的结构生物化学和电磁学，并可能为威胁检测和人类健康提供病毒传感的根本改变。开发了用于分子电子学和纳米医学系统的纳米结构材料的计算机辅助设计方法。为STEM教育中代表性不足的群体创造了机会。为什么激励?电气工程师了解非耗散振荡电路元件的重要性。化学家和物理学家在多尺度理论方面有专长。生物学家了解类病毒颗粒的反应。很少有科学家能理解所有这些话题。