CAREER: New Metal Catalyzed Reactions for Trans-Alkynevinylation

通过这一职业奖，化学催化项目支持锡拉丘兹大学化学系丹尼尔·A·克拉克教授的研究。克拉克教授开发了新的催化方法，用于烯烃的硅乙烯基化反应。这项研究的第一个目标是利用乙烯，一种丰富的化学原料，作为偶联伙伴来生产含有二烯的高度取代的环状化合物。仔细研究了乙烯对炔烃硅基乙烯基化立体化学产物的作用。第二个目标是探索使用乙烯基硼酸盐作为与炔烃的偶联伙伴来创建更复杂的体系。这种方法可能会消除废流，因为不需要对起始材料进行预功能化。拟议研究的成功实施预计将对有机化学和农用化学、制药和材料工业领域产生积极影响。该职业奖还为教育项目提供支持，特别是在锡拉丘兹和北锡拉丘兹公立学校为科学、技术、工程和数学(STEM)教育工作者开设讲习班。克拉克教授计划的目标是提供可以由K-12教师在课堂环境中实施的授课材料和化学实验。克拉克教授的计划与锡拉丘兹大学(SU)的愿景一致，名为：把学术付诸行动，SU对持续社区参与的承诺。

With this CAREER Award, the Chemical Catalysis Program supports the research of Professor Daniel A. Clark of the Department of Chemistry at Syracuse University. Professor Clark develops new catalytic methods for the silylvinylation of alkynes. The first objective of this research is to utilize ethylene, an abundant chemical feedstock, as a coupling partner to produce highly substituted cyclic compounds that contain a diene. The role of ethylene on the stereochemical outcome of silylvinylation of alkynes is carefully examined. The second objective explores the use of vinylboronates as coupling partners with alkynes to create more complex systems. This approach is likely to eliminate waste streams as no pre-functionalization of starting materials is required. The successful implementation of the proposed research is expected to positively impact the fields of organic chemistry and agrochemistry, pharmaceuticals, and the materials industry. The CAREER award also provides support for educational programs; specifically, the creation of workshops for Science, Technology, Engineering, and Mathematics (STEM) educators in the Syracuse and North Syracuse public schools. The goal of Professor Clark's program is to offer access to lecture materials and chemical experiments that can be implemented in a classroom environment by K-12 teachers. Professor Clark's program is in line with the vision of Syracuse University (SU) entitled: Scholarship in Action, a commitment from SU to sustained community engagement.