SusChEM: CAREER: Catalytic Methods for Direct Access to Tetrasubstituted Nitrogen-Containing Molecules

SusChEM：职业：直接获得四取代含氮分子的催化方法

• 批准号: 1352665
• 负责人: Catharine Larsen
• 金额: $ 59.98万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2019-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1352665&HistoricalAwards=false
• 关键词: SusChEM; CAREER; Catalytic; Methods; Direct

The Chemical Catalysis (CAT) Program in the NSF Division of Chemistry is supporting the research of Professor Catharine H. Larsen at the University of California, Riverside. The project focuses on developing a new series of catalysts to prepare amine-bearing tetrasubstituted carbon centers in a single, efficient, catalytic process. The reactions minimize waste with the sole by-product being one equivalent of water. The resulting molecular building blocks form the core of therapeutic natural products, biomedical probes, and pharmaceuticals. The outreach activities integrate green chemistry principles, bringing chemistry to students and the wider public through art.Professor Larsen's project develops a one-step catalytic methods to synthesize amine-bearing tetrasubstituted carbon centers. A dual metal system is being used to overcome the high energy barrier required in forming key molecular intermediates for direct access to highly hindered compounds. The approach uses sustainable catalysts to access asymmetric, tetrasubstituted carbons in a single step to provide hindered organic amines. Professor Larsen showcases the influence of green chemistry and catalysis through lectures, laboratory courses, presentations to the Women in Science Engaging Riverside (WISER) club, and "The Science of Art" program, which is integrated into the Riverside Art Museum's "Walk and Wonder" tours. The latter outreach inspires socioeconomically disadvantaged 2nd- and 5th-grade students through tactile experimentation with the chemistry involved in the creation of paintings, sculptures, and other media, providing a positive reaction to science.

NSF化学部的化学催化计划（CAT）计划支持加利福尼亚大学河滨分校的Catharine H. Larsen教授的研究。该项目着重于开发一系列新的催化剂，以在单个，高效的催化过程中准备含胺的四碱成立碳中心。这些反应将唯一副产品的废物最小化，相当于水。所得的分子构建块构成了治疗天然产物，生物医学探针和药物的核心。外展活动将绿色的化学原则纳入了绿色化学原则，通过艺术将化学作用为学生和更广泛的公众带来。双重金属系统被用来克服形成关键分子中间体所需的高能屏障，以直接进入高度阻碍的化合物。该方法使用可持续的催化剂在单一步骤中访问不对称的四重取代的碳，以提供阻碍的有机胺。拉尔森教授通过讲座，实验室课程，向妇女介绍与河滨俱乐部（WISER）俱乐部的妇女的演讲以及“艺术科学”计划的影响，展示了绿色化学和催化的影响，该计划融入了河滨艺术博物馆的“步行和奇迹”之旅中。后者的宣传激发了社会经济不利的二年级和5年级学生，通过触觉实验，涉及绘画，雕塑和其他媒体所涉及的化学反应，从而对科学产生了积极的反应。