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LTREB RENEWAL: Fitness consequences of pleiotropic androgen effects in free-living mammals

LTREB RENEWAL：多效性雄激素效应对自由生活的哺乳动物的健康影响

基本信息

批准号：
1353110
负责人：
Kay Holekamp
金额：
$ 45万
依托单位：
Michigan State University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-01 至 2020-03-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1353110&HistoricalAwards=false
关键词：
LTREB RENEWAL Fitness consequences pleiotropic

项目摘要

Current understanding of the long-term effects of prenatal hormone exposure on offspring fitness in natural populations is extremely limited, particularly in viviparous species. The proposed research investigates the fitness consequences of prenatal androgen exposure in a long-lived mammalian carnivore, the spotted hyena. Wild hyenas are studied in Kenya to document correlates and consequences of naturally-occurring variation in early androgen exposure. Cubs born to mothers with known concentrations of androgens during pregnancy are followed into adulthood to test a hypothesis suggesting that androgen-induced variation in cub behavior and morphology is associated with variation in fitness. Two other competing hypotheses are also evaluated, each suggesting different extents to which opposing hormone effects might constrain adaptive evolution. This work will permit uniquely integrated study in long-lived mammals of the development of hormonally-induced traits, from their induction in the womb to their consequences in natural populations. It will be important for understanding more broadly the role of prenatal androgen exposure in the generation of variation in behavior and morphology, and the role played by androgens in the evolution of mammalian life histories. This research crosses disciplinary boundaries and offers unique and highly valuable international training opportunities for American students. The work also trains Kenyan students, and supports Masai students in local elementary schools near the study site. In addition, project personnel work closely with the public media in the USA and abroad, maintain an educational website, and give many lectures each year to lay audiences. Finally, via a web portal this research makes available to other researchers and the general public core data tables in a database that documents hyena behavior, demography, and physiology at the study site since 1988. This project is jointly supported by the Animal Behavior Program and International Science and Engineering.

目前对自然种群中产前激素暴露对后代健康的长期影响的了解极其有限，特别是在胎生物种中。这项拟议的研究调查了产前雄激素暴露对长寿哺乳动物食肉动物斑鬣狗的健康影响。在肯尼亚对野生鬣狗进行了研究，以记录早期雄激素暴露中自然发生的变化的相关性和后果。怀孕期间雄激素浓度已知的母亲所生的幼崽被跟踪到成年，以测试一个假设，该假设表明雄激素引起的幼崽行为和形态的变化与健康的变化有关。还评估了另外两个相互竞争的假设，每个假设都表明相反的激素效应可能在不同程度上限制适应性进化。这项工作将允许对长寿哺乳动物进行独特的综合研究，研究激素诱导的性状的发展，从它们在子宫中的诱导到它们在自然群体中的后果。这对于更广泛地了解产前雄激素暴露在行为和形态变异产生中的作用，以及雄激素在哺乳动物生命史进化中所发挥的作用非常重要。这项研究跨越了学科界限，为美国学生提供了独特且极具价值的国际培训机会。这项工作还培训肯尼亚学生，并为研究地点附近当地小学的马赛学生提供支持。此外，项目人员与美国和国外的公共媒体密切合作，维护一个教育网站，每年为非专业观众举办多次讲座。最后，通过门户网站，这项研究向其他研究人员和公众开放数据库中的核心数据表，该数据库记录了自 1988 年以来研究地点的鬣狗行为、人口统计和生理学。该项目由动物行为计划和国际科学与工程联合支持。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Beyond infant death: the hidden costs of male immigration in geladas

除了婴儿死亡之外：狒狒中男性移民的隐性成本

DOI：
10.1016/j.anbehav.2019.11.010
发表时间：
2020
期刊：
Animal Behaviour
影响因子：
2.5
作者：
Schneider-Crease, India;Chiou, Kenneth L.;Snyder-Mackler, Noah;Bergman, Thore J.;Beehner, Jacinta C.;Lu, Amy
通讯作者：
Lu, Amy

Geographic distribution of microsatellite alleles in geladas (Primates, Cercopithecidae): Evidence for three evolutionary units

狒狒（灵长类、鹿科）微卫星等位基因的地理分布：三个进化单位的证据

DOI：
10.1111/zsc.12451
发表时间：
2020
期刊：
Zoologica Scripta
影响因子：
2.5
作者：
Trede, Franziska;Lemkul, Anna;Atickem, Anagaw;Beehner, Jacinta C.;Bergman, Thore J.;Burke, Ryan;Fashing, Peter J.;Knauf, Sascha;Mekonnen, Addisu;Moges, Amera
通讯作者：
Moges, Amera

Low rank and primiparity increase fecal glucocorticoid metabolites across gestation in wild geladas