MRI: Acquisition of a Single Crystal X-Ray Diffractometer for Molecular Structure Analysis at Western Washington University

在主要研究仪器计划(MRI)的这一奖项和化学研究仪器计划(CRIF)的支持下，西华盛顿大学的Paul Spiegel教授和他的同事John Gilbertson将获得一台X射线衍射仪。通常，X射线衍射仪可以准确和精确地测量分子的完整三维结构，包括键距离和角度，并提供关于分子相对于邻近分子的空间排列的准确信息。这里描述的研究将影响许多领域，包括有机化学和无机化学、材料化学和生物化学。该仪器将是西华盛顿大学以及西雅图地区邻近机构教学、研究和研究培训的组成部分。该奖项旨在加强各级研究和教育，特别是在以下领域：(A)确定用于开发重组血液替代品的环状排列的血红蛋白结构；(B)研究血友病治疗的免疫反应；(C)测定工程蛋白复合体的结构生物学；(D)测定用于二氧化碳减排的小分子无机复合体的结构；(E)利用扩展的圆周率体系测定用于太阳能转换的有机荧光团的结构；(F)用于光学和电子性能的量子点三元纳米晶体的结构分析；(G)用于加氢处理石油基原料的核壳纳米催化剂的微型X射线衍射分析；(H)维林/明胶蛋白家族细胞骨架调节剂的结构研究。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Paul Spiegel from Western Washington University and colleague John Gilbertson will acquire an X-ray diffractometer. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here will impact a number of areas, including organic and inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research and research training not only at Western Washington University but also at neighboring institutions from the Seattle area.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) determining the structure of circularly permuted hemoglobin constructs for the development of recombinant blood replacements; (b) studying the immune response to hemophilia treatment; (c) determining the structural biology of engineered protein complexes; (d) determining the structure of small molecule inorganic complexes for the application of carbon dioxide reduction; (e) structure determination of organic fluorophores with extended pi systems for use in solar energy conversion; (f) structural analysis of quantum dot ternary nanocrystals for the application of optical and electronic properties; (g) microscale X-ray diffraction analysis of core-shell nanocatalysts for hydrotreating applications to petroleum-based feedstocks; and (h) structural studies of the villin/gelsolin family of cytoskeleton regulators.