MRI: Acquisition of A Single-Crystal X-Ray Diffractometer—Synthesize, Crystallize, Virtualize

MRI：获取单晶 X 射线衍射仪——合成、结晶、虚拟化

• 批准号: 2215262
• 负责人: Semin Lee
• 金额: $ 28.44万
• 依托单位: Louisiana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2215262&HistoricalAwards=false
• 关键词: MRI; Acquisition; Single; Crystal; Ray

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Louisiana State University is acquiring a dual-source single crystal diffractometer equipped with Cu and Ag X-ray sources, an enhanced detector, and a cryogenic device to support the research of Professor Semin Lee and colleagues Noemie Elgrishi, Victor Garcia Lopez, Matthew Chambers, Fatima Rivas. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here impact many areas, including organic and inorganic chemistry, materials chemistry, biochemistry, and catalysis. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate students in chemistry and biochemistry at this institution. Professor Lee and his collaborators are developing a program to enhance virtual reality-based teaching, combined with synthesis and crystallography projects at a number of HBCU/PUI institutions throughout Louisiana.The award is aimed at enhancing research and education at all levels. Research enabled by the instrument is focused on alkyne metathesis catalysts, molecular metallo-cages , natural products, molecular catalysts for energy- relevant transformations, light-activated molecular motors, boron dipyrromethene-based fluorophores, new organic reactions for drug discovery, protein structure: chlamydia trachomatis, quantum materials.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器项目联合支持。路易斯安那州立大学正在购买一台配备铜和银x射线源的双源单晶衍射仪、一台增强型探测器和一台低温设备，以支持Semin Lee教授及其同事Noemie Elgrishi、Victor Garcia Lopez、Matthew Chambers和Fatima Rivas的研究。一般来说，x射线衍射仪可以精确测量分子的完整三维结构，包括键距和角度，并提供有关分子相对于邻近分子的空间排列的准确信息。这里描述的研究影响许多领域，包括有机和无机化学，材料化学，生物化学和催化。该仪器是该机构化学和生物化学本科生和研究生的教学、研究和研究训练的一个组成部分。Lee教授和他的合作者正在开发一个项目，以加强基于虚拟现实的教学，并结合路易斯安那州HBCU/PUI机构的合成和晶体学项目。该奖项旨在加强各级的研究和教育。该仪器支持的研究主要集中在炔复分解催化剂、分子金属笼、天然产物、能量相关转化的分子催化剂、光激活分子马达、基于二吡咯甲基硼的荧光团、用于药物发现的新有机反应、蛋白质结构：沙眼衣原体、量子材料。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。