CAREER: Two phenotypes, one genome: genomic conflict as a research framework for professional development of science educators
职业:两种表型,一种基因组:基因组冲突作为科学教育者专业发展的研究框架
基本信息
- 批准号:1453089
- 负责人:
- 金额:$ 90万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-03-15 至 2020-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Genomic conflict occurs when different organisms must be produced from the same set of genes, akin to building different structures from the same set of blueprints. A common example is the production of males and females from the shared genome of a species. Conflict arises because genes that are evolutionarily favored in males are disfavored in females, and vice versa. If these conflicts are difficult to resolve, then they will have profound impacts on the evolution of most species. However, the basic question of how to produce two different organisms from the same set of genes transcends evolutionary biology because it involves every step along the way from the expression of genes to the hormones that regulate the development of each sex. This research will provide fundamental insights into the relationship between the genome and the phenotype, along with significant training of K-12 teachers in cutting-edge science. This project has three goals: (1) use new sequencing technology to measure the amount of genomic conflict in a wild population of a lizard in which males and females are so different that they are often mistaken for separate species, (2) test whether this conflict is mitigated by a recently discovered phenomenon in which females appear to adaptively bias the sex of their offspring, and (3) combine breeding experiments with the latest methods for simultaneously measuring the expression of thousands of individual genes to test whether sex differences in hormone levels can reduce genome-wide conflict. This research will support a new professional development program for high school science teachers from underserved schools, who will work alongside project personnel and a national network of collaborators in science and education.
当不同的生物体必须由同一组基因产生时,就会发生基因组冲突,这类似于从同一组蓝图中构建不同的结构。一个常见的例子是从一个物种的共享基因组中产生雄性和雌性。冲突的产生是因为进化上有利于男性的基因在女性中不受欢迎,反之亦然。如果这些冲突难以解决,那么它们将对大多数物种的进化产生深远的影响。然而,如何从同一组基因中产生两种不同的生物体这一基本问题超越了进化生物学,因为它涉及从基因表达到调节两性发育的激素的沿着每一步。这项研究将为基因组和表型之间的关系提供基本的见解,沿着K-12教师在尖端科学方面的重要培训。该项目有三个目标:(1)使用新的测序技术来测量野生蜥蜴种群中基因组冲突的数量,其中雄性和雌性差异如此之大,以至于它们经常被误认为是不同的物种,(2)测试这种冲突是否被最近发现的现象所缓解,其中雌性似乎适应性地偏向其后代的性别,(3)将联合收割机育种实验与同时测量数千个个体基因表达的最新方法相结合,以测试激素水平的性别差异是否可以减少全基因组的冲突。这项研究将支持一个新的专业发展计划,高中科学教师从服务不足的学校,谁将与项目人员和国家网络的合作者在科学和教育工作。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Evolution of hormone-phenotype couplings and hormone-genome interactions
- DOI:10.1016/j.yhbeh.2022.105216
- 发表时间:2022-06-28
- 期刊:
- 影响因子:3.5
- 作者:Cox,Robert M.;Hale,Matthew D.;Cox,Christian L.
- 通讯作者:Cox,Christian L.
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Robert Cox其他文献
Repackaged Android Application Classification Through Static Global Image Feature Analysis
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
Robert Cox - 通讯作者:
Robert Cox
New applications, new global audiences
新的应用程序,新的全球受众
- DOI:
- 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
Sue Gregory;Brent Gregory;D. Wood;J. O’Connell;Scott Grant;Mathew Hillier;D. Butler;Yvonne Masters;Frederick Stokes;Marcus McDonald;Sasha Nikolic;David Ellis;T. Kerr;S. Freitas;H. Farley;Stefan Schutt;J. Sim;Belma Gaukrodger;Lisa Jacka;Joanne Doyle;P. Blyth;D. Corder;Torsten Reiners;Dale Linegar;Merle Hearns;Robert Cox;J. Jegathesan;Suku Sukunesan;K. Flintoff;Leah Irving - 通讯作者:
Leah Irving
Feasibility of using a wireless mesh sensor network in a coal-fired power plant
在燃煤电厂使用无线网状传感器网络的可行性
- DOI:
10.1109/secon.2010.5453846 - 发表时间:
2010 - 期刊:
- 影响因子:0
- 作者:
Aaron Hussey;Asis Nasipuri;Robert Cox;J. Sorge - 通讯作者:
J. Sorge
An experimental evaluation of tiling and shackling for memory hierarchy management
内存层次管理的平铺和束缚的实验评估
- DOI:
10.1145/305138.305243 - 发表时间:
1999 - 期刊:
- 影响因子:0
- 作者:
Induprakas Kodukula;K. Pingali;Robert Cox;D. Maydan - 通讯作者:
D. Maydan
EPIC-RoofNet : An Experimental Testbed for Solar-powered Wireless Sensor Networks
EPIC-RoofNet:太阳能无线传感器网络的实验测试台
- DOI:
- 发表时间:
2013 - 期刊:
- 影响因子:0
- 作者:
Amitangshu Pal;A. Harris;J. Anderson;Asis Nasipuri;Robert Cox;J. Conrad - 通讯作者:
J. Conrad
Robert Cox的其他文献
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{{ truncateString('Robert Cox', 18)}}的其他基金
Eco-evolutionary dynamics of parasitism mediated through variance in host fitness
通过宿主适应性差异介导的寄生生态进化动力学
- 批准号:
2310874 - 财政年份:2023
- 资助金额:
$ 90万 - 项目类别:
Standard Grant
Collaborative Research: Evolutionary reversals in hormonal modulation of growth-regulatory gene networks
合作研究:生长调节基因网络激素调节的进化逆转
- 批准号:
1755026 - 财政年份:2018
- 资助金额:
$ 90万 - 项目类别:
Standard Grant
DISSERTATION RESEARCH: Revealing the genomic targets of opposing natural selection that differ between females and males
论文研究:揭示女性和男性之间不同的反对自然选择的基因组目标
- 批准号:
1601148 - 财政年份:2016
- 资助金额:
$ 90万 - 项目类别:
Standard Grant
DISSERTATION RESEARCH: Male fitness in a single cell: The evolutionary significance of male reproductive cell morphology
论文研究:单细胞的男性适应性:男性生殖细胞形态的进化意义
- 批准号:
1501680 - 财政年份:2015
- 资助金额:
$ 90万 - 项目类别:
Standard Grant
MEETING: Evolutionary Endocrinology: Hormones as Mediators of Evolutionary Phenomena (SICB Symposium, January 5, 2016 in Portland, OR)
会议:进化内分泌学:激素作为进化现象的中介(SICB 研讨会,2016 年 1 月 5 日在俄勒冈州波特兰市)
- 批准号:
1539936 - 财政年份:2015
- 资助金额:
$ 90万 - 项目类别:
Standard Grant
I/UCRC Phase I: Sustainably Integrated Buildings and Sites
I/UCRC 第一阶段:可持续整合的建筑和场地
- 批准号:
1161031 - 财政年份:2012
- 资助金额:
$ 90万 - 项目类别:
Continuing Grant
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