The Fundamental Dynamics and Optical Control of Molecular Devices

分子器件的基本动力学和光学控制

• 批准号: 1464584
• 负责人: Roseanne Sension
• 金额: $ 53.65万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1464584&HistoricalAwards=false
• 关键词: Fundamental; Dynamics; Optical; Control; Molecular

With this award, the Chemical Structure, Dynamics and Mechanisms (CSDM-A) Program of the Division of Chemistry is funding Professor Sension of the University of Michigan, Ann Arbor to investigate molecular-based components of optically controlled nanomachines. These devices aim to provide a means for nanoscale remote-controlled sensing, transport, synthesis, memory, logic circuits, and information storage. The practical development of these devices faces significant challenges in design, arising from incomplete knowledge of the complicated systems involved. Professor Sension will use ultrafast spectroscopy to study the fundamental chemistry and physics of molecular processes relevant to molecular switches based on photochemical ring-opening reactions, molecular motors, based on isomerization around a central bond, and vitamin B12 analogues capable of photoactivated drug delivery. Methods will also be developed to use the wavelength, energy, phase, beam profile, polarization, and temporal structure of laser pulses intelligently to manipulate molecular constituents of potential devices. Students engaged in this research will receive training in modern experimental physical chemistry techniques, working on research problems relevant to biological processes, as well as nanotechnology and engineering. One of the most important reactions is the electrocyclic ring-opening reaction of substituted cyclohexadiene active in many molecular switches. Fundamental studies of small cyclohexadiene containing molecules will provide experimental data to inform theoretical efforts in a synergistic relationship. Study of the ring-opening reaction of 7-dehydrocholesterol is important as this is precisely the reaction that occurs in human skin to produce pre-vitamin D. The photoinitiated ring-opening reaction will be studied in liposomes, a physiologically relevant model system. This project also seeks to increase the fundamental understanding of cis-trans isomerization reactions key to molecular motors. The photochemical reactions of cobalamins are finding increased application in the sensors, antivitamins, and molecular drug-delivery devices. Fundamental studies of the ultrafast internal conversion and photodissociation of active cobalamins will be performed to understand the photochemistry and photophysics of these systems as a function of ligand, wavelength, temperature, and environment.

化学系的化学结构、动力学和机理(CSDM-A)项目获得这一奖项，资助密歇根大学安娜堡分校的Sension教授研究基于分子的光学控制纳米机器组件。这些设备旨在为纳米级遥控传感、传输、合成、存储、逻辑电路和信息存储提供一种手段。由于对涉及的复杂系统的不完全了解，这些设备的实际开发在设计上面临着巨大的挑战。森森教授将使用超快光谱学研究与基于光化学环开环反应的分子开关、基于中心键周围异构化的分子马达以及能够光激活药物输送的维生素B12类似物相关的分子过程的基本化学和物理。还将开发利用激光脉冲的波长、能量、相位、光束轮廓、偏振和时间结构来智能地操纵潜在设备的分子成分的方法。从事这项研究的学生将接受现代实验物理化学技术方面的培训，致力于与生物过程以及纳米技术和工程相关的研究问题。其中最重要的反应之一是许多分子开关中活性的取代环己二烯的电环开环反应。对环己二烯小分子的基础研究将为协同关系中的理论工作提供实验数据。研究7-脱氢胆固醇的开环反应很重要，因为这正是人体皮肤中发生的产生维生素D前体的反应。光引发的开环反应将在脂质体中进行研究，这是一个与生理相关的模型系统。该项目还寻求增加对分子马达关键的顺反异构化反应的基本了解。钴蛋白的光化学反应在传感器、抗维生素和分子药物输送设备中的应用越来越多。我们将对活性钴胺的超快内转换和光解离进行基础研究，以了解这些体系的光化学和光物理随配体、波长、温度和环境的变化。