Nanoscale Curvature Effects on the Properties of Anisotropic Nanomaterials

纳米曲率对各向异性纳米材料性能的影响

• 批准号: 1507790
• 负责人: Teri Odom
• 金额: $ 45万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2019-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1507790&HistoricalAwards=false
• 关键词: Nanoscale; Curvature; Effects; Properties; Anisotropic

With this award the Macromolecular, Supramolecular, and Nanochemistry (MSN) Program in the Chemistry Division is funding Professor Teri Odom at Northwestern University to study a specific type of nanoparticle -gold nanostars-that can be efficiently synthesized. Nanoparticles made from noble metals such as gold and silver are promising in a range of applications, from chemical sensors to optical imaging probes to anti-bacterial agents. However, preparing and controlling specific features (tips, edges, curves) on metal nanoparticles with non-spherical shapes are still challenging. These nanoscopic features are expected to be important as their sizes approach that of molecules. The project aims to obtain nanostars with desired features by tuning the chemistry at the nanoparticle surface. Broader impacts of these unique nanomaterials include integrating the one-pot gold nanostar synthesis with an existing lab on colloidal gold nanoparticles in freshmen general chemistry. In addition, freshman seminars focusing on nanoscience are developing projects similar to 'Ted Ed'-like videos explaining nano-concepts.This proposal seeks to determine how anisotropic nanomaterials that support unique curvature regions of positive, negative, and neutral curvature simultaneously exhibit properties distinct from symmetric (spherical) or elongated (rod-like) nanoparticles. Gold nanostars can serve as a unique model system since they can be synthesized through a seedless method resulting in distinct numbers of branches with tunable thicknesses and lengths. This work aims to resolve the mechanism of seedless growth at the single-particle level as well as determine how gold nanostar sample purity can be optimized by physical post-processing. Other goals include determining the structure-activity relationships of gold nanostars related to ligand attachment. Major outcomes of this work on nanoscale curvature include: (1) identifying functional groups in Good's buffers responsible for the formation gold nanostars with different branch numbers, branch lengths, and negative curvature degrees; (2) resolving the growth mechanism of gold nanostars at the single-particle level using in situ transmission electron microscopy; and (3) determining where biological ligands having secondary structure (double-stranded, looped, quadruplex) preferentially adsorb on the gold nanostars.

凭借该奖项，化学部的大分子，超分子和纳米化学（MSN）计划资助西北大学的Teri Odom教授研究一种可以有效合成的特定类型的纳米颗粒-金纳米星。 由贵金属如金和银制成的纳米颗粒在从化学传感器到光学成像探针到抗菌剂的一系列应用中是有前途的。然而，在具有非球形形状的金属纳米颗粒上制备和控制特定特征（尖端、边缘、曲线）仍然具有挑战性。这些纳米级的功能，预计将是重要的，因为它们的大小接近分子。 该项目旨在通过调整纳米颗粒表面的化学性质来获得具有所需特征的纳米星。这些独特的纳米材料的更广泛的影响包括将一锅金纳米星合成与新生普通化学中现有的胶体金纳米粒子实验室相结合。此外，新生研讨会侧重于纳米科学正在开发类似于'泰德埃德'的视频解释纳米概念的项目。该提案旨在确定如何支持独特的曲率区域的正，负，和中性曲率的各向异性纳米材料同时表现出不同于对称（球形）或细长（棒状）纳米粒子的属性。金纳米星可以作为一个独特的模型系统，因为它们可以通过无籽方法合成，从而产生不同数量的具有可调厚度和长度的分支。这项工作的目的是解决在单粒子水平的无籽生长的机制，以及确定如何可以通过物理后处理优化金纳米星样品的纯度。其他目标包括确定与配体连接相关的金纳米星的结构-活性关系。本研究的主要成果包括：（1）确定了不同分支数目、分支长度和负曲率度的金纳米星形成的Good缓冲层中的功能基团;（2）利用原位透射电子显微镜在单粒子水平上解析了金纳米星的生长机制;以及（3）确定具有二级结构（双链、环状、四链体）的生物配体优先吸附在金纳米星上的位置。