International Collaboration on Nanotube Safety (ICONS) NSF 15-022

纳米管安全国际合作 (ICONS) NSF 15-022

• 批准号: 1530505
• 负责人: James Bonner
• 金额: $ 32万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-11-01 至 2019-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1530505&HistoricalAwards=false
• 关键词: International; Collaboration; Nanotube; Safety; ICONS

Proposal: 1530505 PI: Bonner, James C.This project is the U.S. component of a joint US-European proposal submitted concurrently to the European Research Area for Safe Implementation of Innovative Nanoscience and Nanotechnology (ERA-NET SIINN) in coordination with NSF. The International Collaboration on Nanotube Safety (ICONS) proposal entitled - An integrated testing strategy for mechanistically assessing the respiratory toxicity of functionalized multi-walled carbon nanotubes- creates a complementary and interdisciplinary collaboration between North Carolina State University (NCSU) in the U.S. with three European laboratories in Romania, Belgium, and Germany to integrate transnational expertise in the toxicology of multi-walled carbon nanotubes (MWCNT), which is likely to find increasing practical applications.The International Collaboration on Nanotube Safety (ICONS) project will be a coordinated effort to understand the mechanistic basis of multi-walled carbon nanotubes (MWCNT) toxicity and the physico-chemical parameters that result in toxic effects. Experimental strategy includes - detailed characterization of physico-chemical properties of pristine and functionalized MWCNT, testing them in several in vitro assays, in vivo studies using oropharyngeal aspiration in rats and mice for identifying relevant and meaningful MWCNT candidates, and a 28-day in vivo inhalation study in rats for validation of in vivo relevance, hazard and dose-response characterization. A single and consistent source of MWCNT will be used with various surface functionalizations. NCSU will coordinate and perform in vitro cell testing of MWCNT samples with the Belgium partner to determine the reliability of cultured human lung cells for predicting in vivo outcomes in rats or mice exposed to MWCNT by oropharyngeal aspiration (NCSU and Belgium) or inhalation exposure (Germany). Detailed characterization of functionalized MWCNT in media and tissues (Romania) will complement the bioassays. NCSU will coordinate dissemination of the findings of the ICONS project via a publicly accessible website. The expected outcome of the proposed project is the broad impact through promoting the safe development of nanotechnology through dissemination of the interdisciplinary research findings and NCSU will coordinate findings to the public through a newly created ICONS website that will be linked to other accessible nanotechnology websites. In addition, data will be deposited in the JRC NANOhub database, part of the European Commission Joint Research Center, Institute for Health and Consumer Protection (IHCP). Further, an important expected outcome is that ICONS will serve as a model for U.S.-European interdisciplinary testing of nanomaterials that will promote the safe development of nanotechnology and prevent potential future lung diseases caused by occupational or environmental exposure to nanomaterials. It is anticipated that the ICONS will increase partnerships between academia, industry, and government, thus enhancing economic and safe development of nanotechnology.

提案：1530505 PI：Bonner，James C.该项目是美国联合提案的美国组成部分，该提案同时提交给欧洲研究领域，以安全地实施与NSF协调的创新纳米科学和纳米技术（ERA-NET SIINN）。国际纳米管安全（ICONS）提案的国际合作题为“一种综合测试策略，用于评估功能化的多壁碳纳米管的呼吸毒性 - 在北卡罗来纳州立大学（NCSU）之间，在欧洲的三个欧洲实验室中，贝尔格（Belgium in formania in formania in formania）与贝尔格（Belgium incoritator in Comecition in Comecition in Comecition in Comecition in Comecition in Comecition）建立了互补和跨学科的合作多壁碳纳米管（MWCNT）可能会发现越来越多的实际应用。纳米管安全（ICONS）项目的国际合作将是一项协调的努力，以了解多壁碳纳米管（MWCNT）毒性的机械基础，毒性和物理学化学参数及其有效效应。 Experimental strategy includes - detailed characterization of physico-chemical properties of pristine and functionalized MWCNT, testing them in several in vitro assays, in vivo studies using oropharyngeal aspiration in rats and mice for identifying relevant and meaningful MWCNT candidates, and a 28-day in vivo inhalation study in rats for validation of in vivo relevance, hazard and dose-response表征。单一且一致的MWCNT来源将用于各种表面功能化。 NCSU将与比利时伴侣协调和执行MWCNT样品的体外细胞测试，以确定培养的人类肺细胞的可靠性，以预测通过口交攻击（NCSU和比利时）或吸入式暴露于MWCNT的大鼠或小鼠的体内结局。媒体和组织中功能化MWCNT的详细表征（罗马尼亚）将补充生物测定。 NCSU将通过公共访问的网站协调图标项目的发现。拟议项目的预期结果是通过传播跨学科研究结果来促进纳米技术的安全开发，而NCSU将通过新创建的图标网站向公众协调发现，该网站将与其他可访问的纳米技术网站链接。此外，数据还将存入JRC纳米布数据库，该数据库是欧盟委员会联合研究中心，卫生与消费者保护研究所（IHCP）。此外，一个重要的预期结果是，图标将作为对纳米材料的美国 - 欧洲跨学科测试的模型，这些模型将促进纳米技术的安全发展，并防止因职业或环境暴露于纳米材料而引起的潜在未来肺部疾病。预计这些图标将增加学术界，工业和政府之间的伙伴关系，从而增强纳米技术的经济和安全发展。