International Collaboration on Nanotube Safety (ICONS) NSF 15-022

纳米管安全国际合作 (ICONS) NSF 15-022

• 批准号: 1530505
• 负责人: James Bonner
• 金额: $ 32万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-11-01 至 2019-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1530505&HistoricalAwards=false
• 关键词: International; Collaboration; Nanotube; Safety; ICONS

Proposal: 1530505 PI: Bonner, James C.This project is the U.S. component of a joint US-European proposal submitted concurrently to the European Research Area for Safe Implementation of Innovative Nanoscience and Nanotechnology (ERA-NET SIINN) in coordination with NSF. The International Collaboration on Nanotube Safety (ICONS) proposal entitled - An integrated testing strategy for mechanistically assessing the respiratory toxicity of functionalized multi-walled carbon nanotubes- creates a complementary and interdisciplinary collaboration between North Carolina State University (NCSU) in the U.S. with three European laboratories in Romania, Belgium, and Germany to integrate transnational expertise in the toxicology of multi-walled carbon nanotubes (MWCNT), which is likely to find increasing practical applications.The International Collaboration on Nanotube Safety (ICONS) project will be a coordinated effort to understand the mechanistic basis of multi-walled carbon nanotubes (MWCNT) toxicity and the physico-chemical parameters that result in toxic effects. Experimental strategy includes - detailed characterization of physico-chemical properties of pristine and functionalized MWCNT, testing them in several in vitro assays, in vivo studies using oropharyngeal aspiration in rats and mice for identifying relevant and meaningful MWCNT candidates, and a 28-day in vivo inhalation study in rats for validation of in vivo relevance, hazard and dose-response characterization. A single and consistent source of MWCNT will be used with various surface functionalizations. NCSU will coordinate and perform in vitro cell testing of MWCNT samples with the Belgium partner to determine the reliability of cultured human lung cells for predicting in vivo outcomes in rats or mice exposed to MWCNT by oropharyngeal aspiration (NCSU and Belgium) or inhalation exposure (Germany). Detailed characterization of functionalized MWCNT in media and tissues (Romania) will complement the bioassays. NCSU will coordinate dissemination of the findings of the ICONS project via a publicly accessible website. The expected outcome of the proposed project is the broad impact through promoting the safe development of nanotechnology through dissemination of the interdisciplinary research findings and NCSU will coordinate findings to the public through a newly created ICONS website that will be linked to other accessible nanotechnology websites. In addition, data will be deposited in the JRC NANOhub database, part of the European Commission Joint Research Center, Institute for Health and Consumer Protection (IHCP). Further, an important expected outcome is that ICONS will serve as a model for U.S.-European interdisciplinary testing of nanomaterials that will promote the safe development of nanotechnology and prevent potential future lung diseases caused by occupational or environmental exposure to nanomaterials. It is anticipated that the ICONS will increase partnerships between academia, industry, and government, thus enhancing economic and safe development of nanotechnology.

提案：1530505 PI：Bonner，James C。该项目是与 NSF 协调同时提交给欧洲创新纳米科学和纳米技术安全实施研究领域 (ERA-NET SIINN) 的美欧联合提案的美国部分。纳米管安全国际合作 (ICONS) 提案题为“机械评估功能化多壁碳纳米管呼吸毒性的综合测试策略”，该提案在美国北卡罗来纳州立大学 (NCSU) 与罗马尼亚、比利时和德国的三个欧洲实验室之间建立了互补的跨学科合作，以整合毒理学方面的跨国专业知识。 多壁碳纳米管（MWCNT）的实际应用可能会越来越多。纳米管安全国际合作（ICONS）项目将是一项协调努力，旨在了解多壁碳纳米管（MWCNT）毒性的机制基础以及导致毒性作用的物理化学参数。实验策略包括 - 详细表征原始和功能化 MWCNT 的物理化学性质，在多种体外测定中对其进行测试，在大鼠和小鼠中使用口咽抽吸进行体内研究，以识别相关且有意义的 MWCNT 候选物，以及在大鼠中进行 28 天的体内吸入研究，以验证体内相关性、危害和剂量反应 表征。单一且一致的多壁碳纳米管来源将用于各种表面功能化。 NCSU 将与比利时合作伙伴协调并进行 MWCNT 样品的体外细胞测试，以确定培养的人肺细胞的可靠性，以预测通过口咽抽吸（NCSU 和比利时）或吸入暴露（德国）暴露于 MWCNT 的大鼠或小鼠的体内结果。介质和组织中功能化多壁碳纳米管（罗马尼亚）的详细表征将补充生物测定。 NCSU 将通过一个可公开访问的网站协调 ICONS 项目研究结果的传播。拟议项目的预期成果是通过传播跨学科研究成果促进纳米技术的安全发展，从而产生广泛影响，NCSU 将通过新创建的 ICONS 网站向公众协调研究结果，该网站将链接到其他可访问的纳米技术网站。此外，数据将存储在 JRC NANOhub 数据库中，该数据库是欧盟委员会联合研究中心、健康和消费者保护研究所 (IHCP) 的一部分。此外，一个重要的预期成果是，ICONS 将成为美国-欧洲纳米材料跨学科测试的模型，这将促进纳米技术的安全发展，并预防未来因职业或环境接触纳米材料而引起的潜在肺部疾病。预计 ICONS 将加强学术界、工业界和政府之间的合作，从而促进纳米技术的经济和安全发展。