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CAREER: Optofluidic Lasers at the Liquid-Liquid Interface: A Versatile Biosensing Platform

职业：液-液界面的光流控激光器：多功能生物传感平台

基本信息

批准号：
1554013
负责人：
Yuze (Alice) Sun
金额：
$ 50万
依托单位：
University of Texas at Arlington
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2016
资助国家：
美国
起止时间：
2016-01-01 至 2022-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1554013&HistoricalAwards=false
关键词：
CAREER Optofluidic Lasers Liquid Interface

项目摘要

Proposal TitleCAREER: Optofluidic Lasers at the Liquid-Liquid Interface: A Versatile BiosensingPlatformProject GoalsThis CAREER project investigates bio compatible and bio configurable optofluidiclasers that are self assembled at the liquid-liquid interface and explores theirtransformative applications in bioscience.Nontechnical AbstractThis CAREER project integrates research, educational, and outreach components tolead the innovations in both optofluidic lasers and biosensing technologies inhealthcare. The novel approach is enabled by multidisciplinary integration ofphotonics, microfluidics, MEMS, and bionanotechnologies that creates a newmodality of all liquid laser array that can be controlled and configured bybio/chemical molecules and fluids.The project includes prominent interdisciplinary education and trainingcomponents for undergraduate and graduate students. Plans are also in place topromote involvement of underrepresented students, which leverages the UTA'sstatus as one of the Historically Black Colleges and Universities and MinorityServing Institutions. Special attention is paid to recruit and retain female students inengineering. Finally, the proposed project has extensive outreach programs to trainhigh school students and engineering teachers and to disseminate knowledge andresearch discoveries to the general public.Technical AbstractThe objective of this CAREER project is to develop an array of bio compatible andbio configurable optofluidic lasers that are self assembled at the liquid liquidinterface and study this novel optofluidic laser enabled versatile biosensingtechnology platform to achieve exceptional detection sensitivity, selectivity, andthroughput in various biological and biomedical sensing applications. The proposedoptofluidic laser features a monolayer laser gain material (i.e., only a fewnanometers thick) confined at the liquid liquid interface, which allows biologicaland biochemical molecules to access and directly modulate the laser gain material,and thus forms the basis of enhanced detection sensitivity and selectivity. Theproposed laser sensing platform is studied for rapid and low cost multiplexedcancer biomarker detection towards a final goal of addressing current challenges inthe point of care medical diagnostics and health monitoring. The outcomesgenerated from this research will lead to new development and discoveries in thefield of bioinspired optofluidic devices and engineering, as well as fundamentalresearch on extreme sensing and extreme photonics.

提案标题职业：液-液界面的光流控激光器：多功能生物传感平台项目目标该职业项目研究在液-液界面自组装的生物相容性和生物可配置的光流控激光器，并探索它们在生物科学中的变革性应用。非技术摘要该职业项目集研究、教育和外展于一体引领医疗保健领域光流控激光器和生物传感技术创新的组件。这种新颖的方法是通过光子学、微流体、MEMS和生物纳米技术的多学科集成实现的，创建了一种可以由生物/化学分子和流体控制和配置的全液体激光阵列的新模式。该项目包括针对本科生和研究生的突出的跨学科教育和培训部分。还制定了促进代表性不足的学生参与的计划，这利用了 UTA 作为历史上黑人学院和大学以及少数族裔服务机构之一的地位。特别注意招收和留住工程专业的女学生。最后，拟议项目有广泛的外展计划，以培训高中生和工程教师，并向公众传播知识和研究发现。技术摘要该职业项目的目标是开发一系列生物相容性和生物可配置的光流控激光器，这些激光器在液-液界面上自组装，并研究这种新型光流控激光器启用的多功能生物传感技术平台，以实现在各种生物和生物医学传感应用中具有出色的检测灵敏度、选择性和吞吐量。所提出的光流控激光器具有限制在液液界面的单层激光增益材料（即只有几纳米厚），允许生物和生化分子访问并直接调制激光增益材料，从而形成增强检测灵敏度和选择性的基础。所提出的激光传感平台用于快速、低成本的多重癌症生物标志物检测，最终目标是解决护理点医疗诊断和健康监测中当前的挑战。这项研究的成果将带来仿生光流控器件和工程领域的新发展和发现，以及极限传感和极限光子学的基础研究。