CAREER: Optofluidic Lasers at the Liquid-Liquid Interface: A Versatile Biosensing Platform

提案标题职业：在液-液界面的光流体激光器：一个通用的生物传感平台项目目标这个CAREER项目研究生物相容性和生物可配置的光流体激光器，在液-液界面自组装，并探索其在生物科学中的变革性应用。非技术摘要这个CAREER项目整合了研究，教育和推广组件，以领导在光流体激光器和生物传感技术在医疗保健中的创新。该新方法通过光子学、微流体学、MEMS和生物纳米技术的多学科集成实现，创建了一种新的全液体激光阵列模式，可以由生物/化学分子和流体控制和配置。该项目包括针对本科生和研究生的突出的跨学科教育和培训组件。还制定了促进代表性不足的学生参与的计划，这利用了UTA作为历史上黑人学院和大学以及少数民族服务机构之一的地位。特别注意招收和留住工科女生。最后，技术摘要本CAREER项目的目标是开发一系列生物兼容和生物可配置的光流控激光器，这些激光器在液-液界面处自组装，并研究这种新颖的光流控激光器启用的多功能生物传感技术平台，以实现卓越的生物传感技术。在各种生物和生物医学传感应用中的检测灵敏度、选择性和通量。所提出的掺杂流体激光器的特征在于单层激光增益材料（即，只有几纳米厚）限制在液-液界面处，这允许生物和生化分子进入并直接调制激光增益材料，从而形成增强的检测灵敏度和选择性的基础。拟议的激光传感平台的研究快速和低成本的多路复用癌症生物标志物检测的最终目标是解决当前的挑战，在护理点医疗诊断和健康监测。该研究成果将在生物光流体器件和工程领域以及极端传感和极端光子学的基础研究方面带来新的发展和发现。

Proposal TitleCAREER: Optofluidic Lasers at the Liquid-Liquid Interface: A Versatile BiosensingPlatformProject GoalsThis CAREER project investigates bio compatible and bio configurable optofluidiclasers that are self assembled at the liquid-liquid interface and explores theirtransformative applications in bioscience.Nontechnical AbstractThis CAREER project integrates research, educational, and outreach components tolead the innovations in both optofluidic lasers and biosensing technologies inhealthcare. The novel approach is enabled by multidisciplinary integration ofphotonics, microfluidics, MEMS, and bionanotechnologies that creates a newmodality of all liquid laser array that can be controlled and configured bybio/chemical molecules and fluids.The project includes prominent interdisciplinary education and trainingcomponents for undergraduate and graduate students. Plans are also in place topromote involvement of underrepresented students, which leverages the UTA'sstatus as one of the Historically Black Colleges and Universities and MinorityServing Institutions. Special attention is paid to recruit and retain female students inengineering. Finally, the proposed project has extensive outreach programs to trainhigh school students and engineering teachers and to disseminate knowledge andresearch discoveries to the general public.Technical AbstractThe objective of this CAREER project is to develop an array of bio compatible andbio configurable optofluidic lasers that are self assembled at the liquid liquidinterface and study this novel optofluidic laser enabled versatile biosensingtechnology platform to achieve exceptional detection sensitivity, selectivity, andthroughput in various biological and biomedical sensing applications. The proposedoptofluidic laser features a monolayer laser gain material (i.e., only a fewnanometers thick) confined at the liquid liquid interface, which allows biologicaland biochemical molecules to access and directly modulate the laser gain material,and thus forms the basis of enhanced detection sensitivity and selectivity. Theproposed laser sensing platform is studied for rapid and low cost multiplexedcancer biomarker detection towards a final goal of addressing current challenges inthe point of care medical diagnostics and health monitoring. The outcomesgenerated from this research will lead to new development and discoveries in thefield of bioinspired optofluidic devices and engineering, as well as fundamentalresearch on extreme sensing and extreme photonics.