SHF: Medium: Collaborative Research:Materials authentication using nuclear quadrupole resonance spectroscopy

SHF：媒介：合作研究：使用核四极共振光谱进行材料鉴定

• 批准号: 1563688
• 负责人: Soumyajit Mandal
• 金额: $ 65万
• 依托单位: Case Western Reserve University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-15 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1563688&HistoricalAwards=false
• 关键词: SHF; Medium; Collaborative; Research; Materials

Counterfeit and substandard pharmaceuticals, dietary supplements, and food items containing extremely harmful contaminants have emerged as a major problem worldwide for the health industry. High-value items such as packaged medicines, which are often sold online through untrusted supply chains, are particularly prone to fraud. This project aims to develop and test novel low-cost materials authentication techniques that would enable end users to easily and reliably verify the chemical composition of medicines and dietary supplements. The widespread adoption of the proposed authentication technology could have an impact on public health by significantly enhancing the security of the supply chain for pharmaceutical and food products. The proposed authentication approach is based on comparing the Nuclear Quadrupole Resonance (NQR) spectra generated by the material under test with reference spectra stored in a secure database. The atoms of about half of all the elements in the periodic table contain so-called quadrupolar nuclei that generate NQR signals. This project will focus on the spectra of nitrogen, which is found in a large majority of pharmaceutical products. The NQR spectra are highly sensitive to chemical composition and physical properties, and thus act as unique "chemical fingerprints" that are difficult to emulate or falsify. Low power portable electronics and an integrated system resulting in instrumentation for noninvasive, nondestructive and quantitative testing will be developed for combining sensing, software, and data collection/analysis.

假冒伪劣药品、膳食补充剂和含有极其有害污染物的食品已成为全球卫生行业的一个主要问题。包装药品等高价值物品通常通过不可信的供应链在网上销售，特别容易发生欺诈。该项目旨在开发和测试新型低成本材料认证技术，使最终用户能够轻松可靠地验证药物和膳食补充剂的化学成分。广泛采用拟议的认证技术可能会对公众健康产生影响，因为它会大大提高药品和食品供应链的安全性。所提出的认证方法是基于比较的核四极共振（NQR）谱所产生的材料在测试与参考光谱存储在一个安全的数据库。元素周期表中大约一半的元素的原子都含有产生NQR信号的所谓四极核。该项目将侧重于氮的光谱，这是在大多数药品中发现。NQR光谱对化学成分和物理性质高度敏感，因此充当难以模仿或伪造的独特“化学指纹”。低功耗便携式电子设备和一个集成系统，从而在仪器的非侵入性，无损和定量检测将开发相结合的传感，软件和数据收集/分析。

项目成果

Single-shot spatially-localized NQR using field-dependent relaxation rates

• DOI: 10.1016/j.jmr.2019.106660
• 发表时间: 2020-02-01
• 期刊: JOURNAL OF MAGNETIC RESONANCE
• 影响因子: 2.2
• 作者: Chen, Cheng;Tang, Xinyao;Mandal, Soumyajit
• 通讯作者: Mandal, Soumyajit

Broadband quantitative NQR for authentication of vitamins and dietary supplements

• DOI: 10.1016/j.jmr.2017.03.011
• 发表时间: 2017-05-01
• 期刊: JOURNAL OF MAGNETIC RESONANCE
• 影响因子: 2.2
• 作者: Chen, Cheng;Zhang, Fengchao;Mandal, Soumyajit
• 通讯作者: Mandal, Soumyajit

An easily reproducible, hand-held, single-sided, MRI sensor

• DOI: 10.1016/j.jmr.2019.106591
• 发表时间: 2019-11-01
• 期刊: JOURNAL OF MAGNETIC RESONANCE
• 影响因子: 2.2
• 作者: Greer, Mason;Chen, Cheng;Mandal, Soumyajit
• 通讯作者: Mandal, Soumyajit

Authentication of dietary supplements through Nuclear Quadrupole Resonance (NQR) spectroscopy

• DOI: 10.1111/ijfs.13892
• 发表时间: 2018-12-01
• 期刊: INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
• 影响因子: 3.3
• 作者: Masna, Naren Vikram Raj;Zhang, Fengchao;Bhunia, Swarup
• 通讯作者: Bhunia, Swarup