Mechanisms of alimentary chemosensation

食物化学感觉机制

• 批准号: 8070400
• 负责人: Steven D Munger
• 金额: $ 30.39万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8070400
• 关键词: Animals; Appetite Regulation; Cells; Chemicals; Eating; Endocrine system; Etiology; Feeding behaviors; Fiber; Food; Food Preferences; Genes; Glucagon; Glucose; Health; Homeostasis; Hormones; Human; Insulin; Laboratories; Leptin; Link; Maintenance; Metabolic; Metabolic Diseases; Metabolic syndrome; Metabolism; Molecular; Mus; Nerve Fibers; Non-Insulin-Dependent Diabetes Mellitus; Nutrient; Nutritional; Obesity; Physiological; Production; Receptor Signaling; Role; Sensory; Signal Transduction; Signaling Molecule; Stimulus; System; Taste Buds; Taste Perception; Toxin; Variant; afferent nerve; blood glucose regulation; gastrointestinal system; glucagon-like peptide; incretin hormone; insight; nutrition; peptide hormone; receptor; response; sweet taste perception

DESCRIPTION (provided by applicant): A key function of the gustatory system is to detect nutrients, toxins and indicators of spoilage, thus providing critical information to the animal about the quality and nutritional value of food before it is ingested. The ability to detect and discriminate taste stimuli is essential for health and survival, and can drive ingestive behaviors. Therefore, physiological mechanisms that modulate taste function in the context of nutritional needs and metabolic status could optimize ingestive decisions and directly impact human health. Although the gustatory system critically influences food preference, food intake and metabolic homeostasis, the physiological mechanisms that link taste function and metabolism are poorly understood. Recent findings from our laboratory and others suggest that the gustatory and gastrointestinal systems utilize a common molecular toolkit of receptors, signaling molecules and hormones to detect nutrients and other chemicals. This is consistent with a role for taste function in the maintenance of metabolic homeostasis and suggests that sensory function may be modulated in the context of metabolic status. A greater understanding of the interactions between metabolic hormones and the gustatory sensory apparatus would have important consequences for understanding the etiology of metabolic disease. This project will investigate the interactions between taste and hormonal systems in three Aims. In Aim 1, we will examine the contribution of taste receptors and taste receptor variants to the maintenance of glucose homeostasis. In Aim 2, we will characterize the role of two hormones expressed in taste cells and in the digestive system, glucagon-like peptide-1 (GLP-1) and glucagon, in the modulation of taste sensitivity. In Aim 3, we will examine the ability of GLP-1, glucagon and another hormone, leptin, to influence each other's effects on taste function. Together, these studies will offer important new insights into the interplay between taste, nutrition and metabolism and could have broad implications for metabolic diseases such as obesity, Type 2 diabetes mellitus, and the metabolic syndrome. PUBLIC HEALTH RELEVANCE Although the gustatory system critically influences food preference, food intake and metabolic homeostasis, the physiological mechanisms that link taste function and metabolism are poorly understood. Recent findings from our laboratory and others suggest that taste is important for the maintenance of metabolic homeostasis and that taste function may be modulated in the context of metabolic status. The proposed studies will investigate the interactions between taste and hormonal systems, providing important new insights into the interplay between taste, nutrition and metabolism that could have broad implications for metabolic diseases such as obesity, Type 2 diabetes mellitus, and the metabolic syndrome.

描述(申请人提供)：味觉系统的一个关键功能是检测营养物质、毒素和腐烂的指示物，从而在食物被摄取之前向动物提供关于食物质量和营养价值的关键信息。检测和辨别味觉刺激的能力对于健康和生存是必不可少的，并可以驱动进食行为。因此，根据营养需要和代谢状态调节味觉功能的生理机制可以优化摄食决定，并直接影响人类健康。虽然味觉系统对食物偏好、食物摄取和代谢动态平衡有重要影响，但将味觉功能和新陈代谢联系起来的生理机制却知之甚少。我们实验室和其他实验室最近的发现表明，味觉和胃肠系统利用一个由受体、信号分子和激素组成的通用分子工具箱来检测营养和其他化学物质。这与味觉功能在维持代谢动态平衡中的作用是一致的，并表明感觉功能可能在代谢状态的背景下受到调节。更好地理解代谢激素和味觉感觉器之间的相互作用将对理解代谢性疾病的病因具有重要的影响。这个项目将从三个方面研究味觉和荷尔蒙系统之间的相互作用。在目标1中，我们将研究味觉受体和味觉受体变异体在维持血糖稳态中的作用。在目标2中，我们将研究在味觉细胞和消化系统中表达的两种激素，即胰高血糖素样肽-1(GLP-1)和胰高血糖素，在调节味觉敏感性中的作用。在目标3中，我们将研究GLP-1、胰高血糖素和另一种激素瘦素对彼此味觉功能影响的能力。总之，这些研究将为味觉、营养和新陈代谢之间的相互作用提供重要的新见解，并可能对肥胖症、2型糖尿病和代谢综合征等代谢性疾病产生广泛影响。公众健康相关性虽然味觉系统对食物偏好、食物摄入量和代谢动态平衡有重要影响，但将味觉功能和新陈代谢联系起来的生理机制却知之甚少。我们实验室和其他实验室的最新发现表明，味觉对维持代谢稳态很重要，味觉功能可能在代谢状态的背景下受到调节。拟议的研究将调查味觉和激素系统之间的相互作用，为味觉、营养和新陈代谢之间的相互作用提供重要的新见解，这可能对肥胖症、2型糖尿病和代谢综合征等代谢性疾病具有广泛的影响。