Mechanisms of alimentary chemosensation

食物化学感觉机制

基本信息

  • 批准号:
    8479134
  • 负责人:
  • 金额:
    $ 28.87万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-07-01 至 2015-06-30
  • 项目状态:
    已结题

项目摘要

Project Summary A key function of the gustatory system is to detect nutrients, toxins and indicators of spoilage, thus providing critical information to the animal about the quality and nutritional value of food before it is ingested. The ability to detect and discriminate taste stimuli is essential for health and survival, and can drive ingestive behaviors. Therefore, physiological mechanisms that modulate taste function in the context of nutritional needs and metabolic status could optimize ingestive decisions and directly impact human health. Although the gustatory system critically influences food preference, food intake and metabolic homeostasis, the physiological mechanisms that link taste function and metabolism are poorly understood. Recent findings from our laboratory and others suggest that the gustatory and gastrointestinal systems utilize a common molecular toolkit of receptors, signaling molecules and hormones to detect nutrients and other chemicals. This is consistent with a role for taste function in the maintenance of metabolic homeostasis and suggests that sensory function may be modulated in the context of metabolic status. A greater understanding of the interactions between metabolic hormones and the gustatory sensory apparatus would have important consequences for understanding the etiology of metabolic disease. This project will investigate the interactions between taste and hormonal systems in three Aims. In Aim 1, we will examine the contribution of taste receptors and taste receptor variants to the maintenance of glucose homeostasis. In Aim 2, we will characterize the role of two hormones expressed in taste cells and in the digestive system, glucagon-like peptide-1 (GLP-1) and glucagon, in the modulation of taste sensitivity. In Aim 3, we will examine the ability of GLP-1, glucagon and another hormone, leptin, to influence each other's effects on taste function. Together, these studies will offer important new insights into the interplay between taste, nutrition and metabolism and could have broad implications for metabolic diseases such as obesity, Type 2 diabetes mellitus, and the metabolic syndrome.
项目总结

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Peptide regulators of peripheral taste function.
  • DOI:
    10.1016/j.semcdb.2013.01.004
  • 发表时间:
    2013-03
  • 期刊:
  • 影响因子:
    7.3
  • 作者:
    Dotson, Cedrick D.;Geraedts, Maartje C. P.;Munger, Steven D.
  • 通讯作者:
    Munger, Steven D.
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Steven D Munger其他文献

Steven D Munger的其他文献

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{{ truncateString('Steven D Munger', 18)}}的其他基金

Adaptive olfactory threshold testing in the clinical assessment of anosmia
自适应嗅觉阈值测试在嗅觉丧失临床评估中的应用
  • 批准号:
    10491037
  • 财政年份:
    2022
  • 资助金额:
    $ 28.87万
  • 项目类别:
Training Program in Chemosensory Science
化学传感科学培训项目
  • 批准号:
    10439463
  • 财政年份:
    2018
  • 资助金额:
    $ 28.87万
  • 项目类别:
Training Program in Chemosensory Science
化学传感科学培训项目
  • 批准号:
    10202552
  • 财政年份:
    2018
  • 资助金额:
    $ 28.87万
  • 项目类别:
Modulation of Taste-Related Behavior by Molecular Mediators of Appetite & Satiety
食欲分子介质对味觉相关行为的调节
  • 批准号:
    9091556
  • 财政年份:
    2013
  • 资助金额:
    $ 28.87万
  • 项目类别:
Mechanisms of odor detection and transduction
气味检测和传导机制
  • 批准号:
    8490342
  • 财政年份:
    2012
  • 资助金额:
    $ 28.87万
  • 项目类别:
Mechanisms of odor detection and transduction
气味检测和传导机制
  • 批准号:
    8400573
  • 财政年份:
    2012
  • 资助金额:
    $ 28.87万
  • 项目类别:
Chemosensory receptors and the basis of specificity
化学感应受体和特异性的基础
  • 批准号:
    7903521
  • 财政年份:
    2009
  • 资助金额:
    $ 28.87万
  • 项目类别:
Mechanisms of alimentary chemosensation
食物化学感觉机制
  • 批准号:
    8070400
  • 财政年份:
    2009
  • 资助金额:
    $ 28.87万
  • 项目类别:
Mechanisms of alimentary chemosensation
食物化学感觉机制
  • 批准号:
    8278006
  • 财政年份:
    2009
  • 资助金额:
    $ 28.87万
  • 项目类别:
Mechanisms of alimentary chemosensation
食物化学感觉机制
  • 批准号:
    7751640
  • 财政年份:
    2009
  • 资助金额:
    $ 28.87万
  • 项目类别:

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