Mechanisms of alimentary chemosensation
食物化学感觉机制
基本信息
- 批准号:8479134
- 负责人:
- 金额:$ 28.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-07-01 至 2015-06-30
- 项目状态:已结题
- 来源:
- 关键词:AnimalsAppetite RegulationCellsChemicalsEatingEndocrine systemEtiologyFeeding behaviorsFiberFoodFood PreferencesGenesGlucagonGlucoseHealthHomeostasisHormonesHumanInsulinLaboratoriesLeptinLinkMaintenanceMetabolicMetabolic DiseasesMetabolic syndromeMetabolismMolecularMusNerve FibersNon-Insulin-Dependent Diabetes MellitusNutrientNutritionalObesityPhysiologicalProductionReceptor SignalingRoleSensorySignal TransductionSignaling MoleculeStimulusSystemTaste BudsTaste PerceptionToxinVariantafferent nerveblood glucose regulationgastrointestinal systemglucagon-like peptideincretin hormoneinsightnutritionpeptide hormonereceptorresponsesweet taste perception
项目摘要
Project Summary
A key function of the gustatory system is to detect nutrients, toxins and indicators of spoilage,
thus providing critical information to the animal about the quality and nutritional value of food
before it is ingested. The ability to detect and discriminate taste stimuli is essential for health
and survival, and can drive ingestive behaviors. Therefore, physiological mechanisms that
modulate taste function in the context of nutritional needs and metabolic status could optimize
ingestive decisions and directly impact human health. Although the gustatory system critically
influences food preference, food intake and metabolic homeostasis, the physiological
mechanisms that link taste function and metabolism are poorly understood. Recent findings
from our laboratory and others suggest that the gustatory and gastrointestinal systems utilize a
common molecular toolkit of receptors, signaling molecules and hormones to detect nutrients
and other chemicals. This is consistent with a role for taste function in the maintenance of
metabolic homeostasis and suggests that sensory function may be modulated in the context of
metabolic status. A greater understanding of the interactions between metabolic hormones and
the gustatory sensory apparatus would have important consequences for understanding the
etiology of metabolic disease. This project will investigate the interactions between taste and
hormonal systems in three Aims. In Aim 1, we will examine the contribution of taste receptors
and taste receptor variants to the maintenance of glucose homeostasis. In Aim 2, we will
characterize the role of two hormones expressed in taste cells and in the digestive system,
glucagon-like peptide-1 (GLP-1) and glucagon, in the modulation of taste sensitivity. In Aim 3,
we will examine the ability of GLP-1, glucagon and another hormone, leptin, to influence each
other's effects on taste function. Together, these studies will offer important new insights into
the interplay between taste, nutrition and metabolism and could have broad implications for
metabolic diseases such as obesity, Type 2 diabetes mellitus, and the metabolic syndrome.
项目总结
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Gustatory stimuli representing different perceptual qualities elicit distinct patterns of neuropeptide secretion from taste buds.
- DOI:10.1523/jneurosci.0372-13.2013
- 发表时间:2013-04-24
- 期刊:
- 影响因子:0
- 作者:Geraedts MC;Munger SD
- 通讯作者:Munger SD
Peptide regulators of peripheral taste function.
- DOI:10.1016/j.semcdb.2013.01.004
- 发表时间:2013-03
- 期刊:
- 影响因子:7.3
- 作者:Dotson, Cedrick D.;Geraedts, Maartje C. P.;Munger, Steven D.
- 通讯作者:Munger, Steven D.
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Steven D Munger其他文献
Steven D Munger的其他文献
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{{ truncateString('Steven D Munger', 18)}}的其他基金
Adaptive olfactory threshold testing in the clinical assessment of anosmia
自适应嗅觉阈值测试在嗅觉丧失临床评估中的应用
- 批准号:
10491037 - 财政年份:2022
- 资助金额:
$ 28.87万 - 项目类别:
Modulation of Taste-Related Behavior by Molecular Mediators of Appetite & Satiety
食欲分子介质对味觉相关行为的调节
- 批准号:
9091556 - 财政年份:2013
- 资助金额:
$ 28.87万 - 项目类别:
Chemosensory receptors and the basis of specificity
化学感应受体和特异性的基础
- 批准号:
7903521 - 财政年份:2009
- 资助金额:
$ 28.87万 - 项目类别:
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