The role of the alimentary microbiome in the development of mucositis

消化道微生物组在粘膜炎发生中的作用

• 批准号: nhmrc : 1016696
• 负责人: Dr Andrea Stringer
• 金额: $ 20.15万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-alimentary-microbiome-development-mucositis/109800
• 关键词: role; alimentary; microbiome; development; mucositis

Mucositis is a debilitating side effect of cancer treatment, which is currently not treatable or preventable, due to a lack of understanding of how mucositis develops. Previous research has shown that microbes are involved in the development of mucositis in animal models. This project will determine if bacteria in the mouth and intestine play a role in the development of mucositis in patients, and if changes are easily detected, to allow for a more 'personalised' approach to manage mucositis.

粘膜炎是癌症治疗的一种使人衰弱的副作用，由于缺乏对粘膜炎的发展方式，目前无法治疗或预防。先前的研究表明，微生物参与动物模型中粘膜炎的发展。该项目将确定口腔中的细菌和肠道中的细菌是否在患者的粘膜炎发展中起作用，并且是否容易检测到变化，以允许采用更“个性化”的方法来治疗粘膜炎。