PFI:AIR - TT: Wireless implantable pressure sensor for continuous monitoring of chronic disorders

这个PFI：空气技术转换项目专注于转换第一个用于生理监测的无线、微制造、基于微气泡的压力传感器，以填补当前慢性植入式诊断传感器的技术空白。转换后的技术为患有慢性疾病的患者提供可靠的实时压力记录，这些患者通常是终身的，压力升高是其风险因素或指标，并消除了对笨重的外部诊断工具的需求。该微泡压力传感器具有以下独特特点：生物兼容结构、占地面积小(小于0.1平方英尺)。Mm)，无线控制和电源，以及微气泡传输机制。微泡转导机制绕过了机械疲劳和生物污染等故障模式，这些故障模式困扰着依赖于弹性膜偏转的传感器。这些特点提供了一种不显眼、可靠的植入物，与目前最先进的生理压力监测相比，更多地应用于慢性活体监测。该项目将产生一个工作的原型压力传感器和关键数据，以降低正在进行的开发的风险。该项目通过将用于电力和遥测的无线电路集成到现有的原型微气泡传感器中，并生成关于长期精确度、精密度和重复性的关键表征数据，作为将该技术转化为商业部署的必要步骤，解决了当前的技术差距。研究生和本科生研究人员将致力于最终确定设备电子和封装，并通过彻底的台式测试来校准原型压力传感器。此外，参与该项目的所有人员将受益于我们的i-Corps节点和Coulter研讨会系列提供的翻译教育计划，这些计划将使他们了解客户发现、客户访谈、精益创业方法、医疗器械商业化以及监管和报销战略。该团队正在与洛杉矶儿童医院的神经外科医生合作，他们将为脑积水的生物医学技术的设计和部署提供指导。该团队还将利用行业联系和技术商业化计划，在商业化、制造和融资方面提供指导和培训，因为这些计划与将技术转化为竞争性商业现实的潜力有关。该项目的潜在经济和社会影响包括美国在生物医学传感技术方面的更大竞争力，以及通过新的临床压力传感器实现的医疗质量的改善和医疗成本的降低，这种传感器为慢性病患者提供数据驱动的诊断和及时的医疗干预。

This PFI: AIR Technology Translation project focuses on translating the first wireless, microfabricated, microbubble-based pressure sensor for physiological monitoring to fill the current technology gap in chronic, implantable diagnostic sensors. The translated technology offers reliable pressure recordings in real-time for patients suffering from chronic, often life-long medical conditions for which elevated pressure is a risk factor or indicator, and removes the need for bulky exterior diagnostic tools. The microbubble pressure sensor has the following unique features: biocompatible construction, small footprint (less than 0.1 sq. mm.), wireless control and power, and a microbubble transduction mechanism. The microbubble transduction mechanism circumvents failures modes such as mechanical fatigue and biofouling, which plague sensors that rely on deflection in elastic membranes. These features provide for an unobtrusive, reliable implant, with greater application to chronic in vivo monitoring compared to current state-of-the-art in physiological pressure monitoring. The project will result in a working prototype pressure sensor and critical data to de-risk on-going development. This project addresses current technology gaps by integrating wireless circuitry for power and telemetry into the existing prototype microbubble transducer and by generating critical characterization data on long term accuracy, precision and repeatability, as necessary steps for translating the technology toward commercial deployment. Graduate and undergraduate researchers will work to finalize device electronics and packaging and calibrate the prototype pressure sensor with thorough benchtop testing. In addition, all personnel involved in this project, will benefit from translational education programs offered by our I-Corps node and Coulter workshop series that will expose them to customer discovery, customer interviews, Lean Startup methodology, medical device commercialization, and regulatory and reimbursement strategy. The team is collaborating with neurosurgeons at the Children's Hospital Los Angeles; they will provide guidance in design and deployment of biomedical technologies for hydrocephalus. The team will also leverage industry connections and technology commercialization programs for guidance and training on commercialization, manufacturing, and financing as they pertain to the potential to translate the technology into a competitive commercial reality. The potential economic and societal impact of this project include greater US competitiveness in biomedical sensing technology, and the improvements in healthcare quality and reductions in healthcare cost realized by new clinical pressure sensors, that offer data driven diagnostics and timely medical interventions for chronically suffering patients.