Facial Amphiphilic Antimicrobials Biomaterials Containing Fused Multicyclic Structures

非技术：该奖项由南卡罗莱纳大学哥伦比亚分校生物材料项目颁发，旨在促进一类抗菌剂的知识。该奖项由以下项目共同资助：1)材料研究部BMAT项目；2)化学与生物工程、环境与运输系统（ENG）学部的生物技术与生化工程专业。细菌感染现已演变成一场全球性的卫生保健危机。细菌对传统抗生素的耐药性日益增加，这是对抗传染病的一个令人困惑的问题。这个项目的一个直接成果将是开发原型抗菌化合物和聚合物。该项目将为研究生和本科生提供高分子合成、建模和抗菌化合物方面的培训机会。为激发中学生、本科生和研究生对科学技术的兴趣，将开展若干综合教育活动。该项目将继续将非常成功的项目种子暑期研究项目扩展到经济困难家庭的高中生。其他涉及K-12学生的活动包括一系列名为“小世界大影响：纳米生物学”的演讲和生物分子可视化研讨会。该项目还将培训来自代表性不足群体的学生。这些项目也将为学术上的研究生提供综合教育经验。研究成果和发现将在同行评议的期刊上发表，并在国家和国际会议上发表。技术：该项目是一个综合研究、教育和推广计划，旨在设计一类多环萜类衍生的面部两亲化合物和聚合物，作为强大的抗菌剂，可以杀死多种细菌，特别是多药耐药菌株，同时保持对哺乳动物细胞的最小细胞毒性。主要的方法依赖于疏水融合多环二萜和三萜以及离子基序的组合。该项目包括设计面部两亲性结构的基础生物材料研究，揭示对抗细菌的作用机制，以及对抗令人烦恼的细菌耐药性。本项目主要目的是：1)从鼠尾草酸、胆酸和甘草次酸中合成和表征表面两亲性化合物和聚合物，并评价其抗菌活性；2)设计大分子纳米结构作为对抗细菌耐药性的新工具；3)模拟面部两亲性抗菌药物与细菌细胞膜的作用机制。最终目标是将萜类阳离子化合物和聚合物最理想和独特的特性转化为具有当前抗菌材料前所未有的功能和性能的新型抗菌药物。

Non-technical: This award by the Biomaterials program to University of South Carolina at Columbia is to advance the knowledge of a class of antimicrobial agents. This award is co-funded by the following programs: 1) BMAT program in the Division of Materials Research; and 2) Biotechnology and Biochemical Engineering program in the Division of Chemical and Bioengineering, Environmental, and Transport Systems (ENG). Bacterial infections have now evolved into a global healthcare crisis. The ever-increasing emergence of bacterial resistance to traditional antibiotics is a puzzling issue in battling infectious diseases. One direct outcome of this program would be the development of prototype antimicrobial compounds and polymers. This project will provide training opportunities to graduate and undergraduate students in the polymer synthesis, modeling and antimicrobial compounds. Several integrated educational activities for high school, undergraduate and graduate students will be carried out to stimulate their interest in science and technology. This project will continue to expand the highly successful Project Seed Summer Research Program to high school students from economically disadvantaged families. Other activities involving K-12 students include a series of presentations called "Small World with Big Impacts: Nanobiology" and biomolecular visualization workshops. This project will also train students from underrepresented groups. These programs would also serve as integrated educational experience for academically bound graduate students. Research results and discoveries will be disseminated with publications in peer-reviewed journals and presentations at national and international conferences.Technical: This project is an integrated research, education, and outreach program in designing a class of multicyclic terpenoid-derived facial amphiphilic compounds and polymers as robust antimicrobial agents, which could kill a variety of bacteria, particularly multidrug resistant bacterial strains, while maintaining minimal cytotoxicity against mammalian cells. The major approach relies on a combination of hydrophobic fused multicyclic di- and tri-terpenoids and ionic motifs. This project includes fundamental biomaterials research on designing facial amphiphilic structures, uncovering mechanisms of action against bacteria, and fighting vexing bacterial resistance. The main aims of this project are to: 1) synthesize and characterize facial amphiphilic compounds and polymers from carnosic acid, cholic acid and glycyrrhetinic acid, and evaluate their antimicrobial activities; 2) design macromolecular nanostructures as a new tool to fighting bacterial resistance; and 3) model mechanisms of action between facial amphiphilic antimicrobial agents and bacterial cell membranes. The ultimate goal is to translate the most desirable and unique properties of terpenoid-based cationic compounds and polymers into new classes of antimicrobial agents with functionality and performance that are unprecedented for current antimicrobial materials.