Facial Amphiphilic Antimicrobials Biomaterials Containing Fused Multicyclic Structures

非技术性：这个由生物材料项目授予南卡罗来纳大学哥伦比亚分校的奖项是为了促进一类抗菌剂的知识。该奖项由以下项目共同资助：1)材料研究部的BMAT项目；2)化学和生物工程、环境和运输系统(ENG)部门的生物技术和生化工程项目。细菌感染现在已经演变成一场全球医疗危机。越来越多的细菌对传统抗生素产生耐药性，这是与传染病作斗争的一个令人困惑的问题。该计划的一个直接成果将是开发出抗菌化合物和聚合物的原型。该项目将为研究生和本科生提供聚合物合成、建模和抗菌化合物方面的培训机会。开展高中生、本科生、研究生融合教育活动，激发他们的科技兴趣。该项目将继续将非常成功的SEED项目暑期研究计划扩大到来自经济困难家庭的高中生。其他涉及K-12学生的活动包括名为“大影响的小世界：纳米生物学”的一系列演讲和生物分子可视化研讨会。该项目还将培训来自代表性不足群体的学生。这些课程也将为受学业束缚的研究生提供综合教育体验。研究结果和发现将通过发表在同行评议的期刊上和在国内和国际会议上的演讲来传播。技术：该项目是一个综合的研究、教育和推广计划，旨在设计一类多环萜类衍生的面部两亲性化合物和聚合物作为强大的抗菌剂，它可以杀死各种细菌，特别是多药耐药细菌菌株，同时保持对哺乳动物细胞的最低细胞毒性。主要的方法依赖于疏水融合的多环二和三萜类化合物和离子基元的组合。该项目包括设计面部两亲性结构的基础生物材料研究，揭示抗细菌的作用机制，以及对抗令人烦恼的细菌耐药性。本项目的主要目的是：1)从鼠尾草酸、胆酸和甘草次酸合成和表征面部两亲性化合物和聚合物，并评价它们的抗菌活性；2)设计大分子纳米结构作为对抗细菌耐药性的新工具；3)建立面部两亲性抗菌剂与细菌细胞膜之间的作用机理模型。最终目标是将以萜类为基础的阳离子化合物和聚合物最理想和最独特的性质转化为具有当前抗菌材料前所未有的功能和性能的新型抗菌剂。

Non-technical: This award by the Biomaterials program to University of South Carolina at Columbia is to advance the knowledge of a class of antimicrobial agents. This award is co-funded by the following programs: 1) BMAT program in the Division of Materials Research; and 2) Biotechnology and Biochemical Engineering program in the Division of Chemical and Bioengineering, Environmental, and Transport Systems (ENG). Bacterial infections have now evolved into a global healthcare crisis. The ever-increasing emergence of bacterial resistance to traditional antibiotics is a puzzling issue in battling infectious diseases. One direct outcome of this program would be the development of prototype antimicrobial compounds and polymers. This project will provide training opportunities to graduate and undergraduate students in the polymer synthesis, modeling and antimicrobial compounds. Several integrated educational activities for high school, undergraduate and graduate students will be carried out to stimulate their interest in science and technology. This project will continue to expand the highly successful Project Seed Summer Research Program to high school students from economically disadvantaged families. Other activities involving K-12 students include a series of presentations called "Small World with Big Impacts: Nanobiology" and biomolecular visualization workshops. This project will also train students from underrepresented groups. These programs would also serve as integrated educational experience for academically bound graduate students. Research results and discoveries will be disseminated with publications in peer-reviewed journals and presentations at national and international conferences.Technical: This project is an integrated research, education, and outreach program in designing a class of multicyclic terpenoid-derived facial amphiphilic compounds and polymers as robust antimicrobial agents, which could kill a variety of bacteria, particularly multidrug resistant bacterial strains, while maintaining minimal cytotoxicity against mammalian cells. The major approach relies on a combination of hydrophobic fused multicyclic di- and tri-terpenoids and ionic motifs. This project includes fundamental biomaterials research on designing facial amphiphilic structures, uncovering mechanisms of action against bacteria, and fighting vexing bacterial resistance. The main aims of this project are to: 1) synthesize and characterize facial amphiphilic compounds and polymers from carnosic acid, cholic acid and glycyrrhetinic acid, and evaluate their antimicrobial activities; 2) design macromolecular nanostructures as a new tool to fighting bacterial resistance; and 3) model mechanisms of action between facial amphiphilic antimicrobial agents and bacterial cell membranes. The ultimate goal is to translate the most desirable and unique properties of terpenoid-based cationic compounds and polymers into new classes of antimicrobial agents with functionality and performance that are unprecedented for current antimicrobial materials.