Conference: 2016 Biointerface Science: Active, Adaptive, and Responsive Biointerfaces GRC & GRS

学术价值：2016年生物界面科学GRC将探索自然和工程生物材料系统中的主动、适应性和响应性生物界面。我们推断，在自然和仿生系统中，通过界面的中心作用--既有内在的，也有强加的--出现了广泛的复杂、合作和适应行为。生物界面一方面将功能生命模块(如细胞)内不同的生物成分隔开，另一方面促进整合。认识到界面如何决定生物功能，以及在设计生物材料替代生物材料时必须如何考虑界面，需要进行跨学科的讨论，范围从生物大分子和单个细胞到组织和器官。2016 GRC寻求播撒这一话语，帮助产生跨学科的共同语言，并促进跨学科合作。生物界面科学GRC与会者的支持者已经是多学科的。2016年GRC和相关的GRS将邀请生物工程师、化学家、物理学家、材料科学家和生物学家参加一次会议，讨论将生物学和化学的开创性基础进展转化为生物材料、生物传感器和组学产品的挑战。更广泛的影响：生物界面科学、GRC和GRS在促进研究人员职业生涯早期阶段的发展方面发挥着重要作用。GRC模式旨在促进参与者之间进行深入的科学讨论和建立关系的环境。相关的戈登研究研讨会(GRS)将吸引年轻的科学家和研究人员，并让他们参与到最活跃的科学前沿之一。研究生、博士后和其他具有类似经验和教育水平的科学家将在一个高度刺激和非恐吓的环境中聚集在一起，讨论他们目前的研究，并与他们的同行建立非正式的网络，这可能会导致终身合作和科学成就。GRS是由年轻的研究人员在相关GRC的领先科学家的支持下组织的。大多数GRS参与者将参加GRC，紧随其后的是同一地点。国际和平协会作出了协调一致的努力，使妇女、种族/族裔少数群体和残疾人以及过去在科学和工程领域任职人数不足的其他个人得到适当的代表性。

Intellectual Merit:The 2016 GRC in Biointerface Science will explore Active, Adaptive, and Responsive Biointerfaces across natural and engineered biomaterial systems. We reason that broad classes of complex, cooperative, and adaptive behaviors in natural and biomimetic systems emerge through the central roles of interfaces - both intrinsic and imposed. Biointerfaces on the one hand compartmentalize disparate biological components within a functional living module (e.g., a cell) and on the other hand facilitate integration. The appreciation of how interfaces determine biological functions and how interfaces must be considered in devising biomaterial alternatives to their living counterparts requires an interdisciplinary discourse, ranging over biomacromolecules and single cells to tissues and organs. The 2016 GRC seeks to seed this discourse, help generate a common language across disciplines, and foster interdisciplinary collaborations. The constituency of the Biointerface Science GRC attendees is already multidisciplinary. The 2016 GRC and the associated GRS will engage bioengineers, chemists, physicists, materials scientists, and biologists - all participating in a meeting that addresses the challenges in translating ground breaking fundamental advances in biology and chemistry into products in biomaterials, biosensors, and the -omic sciences. Broader Impacts:The Biointerface Science GRC and GRS play important roles in enhancing the development of researchers in early stages of their careers. The GRC format is designed to foster an environment of in-depth scientific discussion and relationship building among participants. The associated Gordon Research Seminar (GRS) will draw in young scientists and researchers, and get them involved with one of the most lively frontiers of science. Graduate students, post-docs, and other scientists with comparable levels of experience and education will come together in a highly-stimulating and non-intimidating environment to discuss their current research and build informal networks with their peers that may lead to a lifetime of collaboration and scientific achievement. The GRS is organized by young investigators with the support of leading scientists from the associated GRC. The majority of the GRS participants will participate in the GRC, which follows immediately at the same site. The PI has made a concerted effort to achieve an appropriate representation of women, racial/ethnic minorities and persons with disabilities, and other individuals who in the past have been underrepresented in science and engineering.