Novel Sensors for Detecting Single Nanoparticles/Molecules
用于检测单个纳米粒子/分子的新型传感器
基本信息
- 批准号:1610674
- 负责人:
- 金额:$ 36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-05-15 至 2019-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Abstract Title: Novel Sensors for Detecting Single Nanoparticles/MoleculesNon-Technical Description: Sensitive detection of a single nanoparticle/molecule is essential for many important applications ranging from medical diagnostics, drug discovery, security screening, to environmental science. The objective of this project is to explore and develop a novel approach for particle and molecule sensing that potentially offers unprecedented sensing resolution significantly beyond current state of the art. By engineering micro/nano-photonic structures to produce intriguing mechanisms to amplify and transduce the sensing signal, and to suppress the noises impacting optical sensing, the PI's group aim to open up a transformative research avenue towards ultra-sensitive, high-speed, label-free detection of single nanoparticles and biomolecules that is of immense importance for broad biomedical, environmental, and security applications. The proposed research, if successful, is expected to have profound impact on broad sensing areas beyond the molecule sensing itself, significantly advancing optical frequency metrology and precision measurement that are impacted by fundamental thermal noises in photonic devices. Fundamental research findings and device innovations will be disseminated to the broader research communities through published papers; the research outcomes will be also incorporated into the courses offered by the PI at the University of Rochester. The proposed research would result in training graduate students and undergraduate students in the diverse interdisciplinary areas of nanophotonics, nonlinear optics, optomechanics, and optical sensing. Through the outreach programs, this project will also help promote the interests and participations of K-12 students, and broaden the participations from underrepresented groups. Technical Description: The proposed research aims to explore nanoparticle and biomolecule sensing based upon novel intriguing light-matter interaction mechanisms inside micro/nano-photonic devices that are able to significantly amplify and transduce the sensing signal and that are able to suppress dramatically the fundamental noises limiting conventional optical sensing. The combined effect leads to a novel sensing methodology with potentially unprecedented sensing resolution. With strong expertise in both the physics and engineering of nanophotonic devices, the PI's group plan to carry out explorative research within the three-year effort, to study the fundamental physics regarding the detection limit of this novel sensing approach, to explore the ultimate sensing resolution offered by the proposed approach for detecting single nanoparticles and single biomolecules, to find the operation conditions that can achieve such resolution, to develop novel nanophotonic device structures on fully integrated platform that are able to provide optimal sensing performance, and to apply them for diverse sensing applications. The preliminary results have shown great promise to achieve these goals.
摘要标题:用于检测单个纳米颗粒/分子的新型传感器非技术描述:单个纳米颗粒/分子的灵敏检测对于从医学诊断、药物发现、安全筛选到环境科学的许多重要应用是必不可少的。本项目的目标是探索和开发一种新的粒子和分子传感方法,该方法可能提供前所未有的传感分辨率,远远超过当前的技术水平。通过设计微/纳米光子结构,产生有趣的机制来放大和放大传感信号,并抑制影响光学传感的噪声,PI小组旨在开辟一条变革性研究途径,实现对单个纳米粒子和生物分子的超灵敏、高速、无标记检测,这对广泛的生物医学、环境和安全应用至关重要。如果这项研究成功,预计将对分子传感本身以外的广泛传感领域产生深远的影响,显著推进受光子器件中基本热噪声影响的光频计量和精密测量。基础研究结果和器械创新将通过发表的论文传播给更广泛的研究群体;研究成果也将纳入罗切斯特大学PI提供的课程中。 拟议的研究将导致培训研究生和本科生在纳米光子学,非线性光学,光学机械学和光学传感的不同跨学科领域。 通过外展计划,该项目还将有助于促进K-12学生的兴趣和参与,并扩大代表性不足的群体的参与。 技术说明:拟议的研究旨在探索基于微/纳米光子器件内部新颖的有趣的光物质相互作用机制的纳米颗粒和生物分子传感,这些器件能够显着放大和转换传感信号,并且能够显着抑制限制传统光学传感的基本噪音。组合效应导致具有潜在的前所未有的感测分辨率的新颖感测方法。凭借在纳米光子器件的物理和工程方面的强大专业知识,PI的团队计划在三年内开展探索性研究,研究关于这种新型传感方法的检测极限的基础物理学,探索由所提出的方法提供的用于检测单个纳米颗粒和单个生物分子的最终传感分辨率,找到可以实现这种分辨率的操作条件,在完全集成的平台上开发能够提供最佳感测性能的新型纳米光子器件结构,并将其应用于各种感测应用。 初步结果表明,实现这些目标大有希望。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Qiang Lin其他文献
Bis(μ-N-benzyl-N-tetradecyldithiocarbamato-κ2S:S)bis[(Nbenzyl-N-tetradecyldithiocarbamato-κ2S,S)zinc(II)]
双(μ-N-苄基-N-十四烷基二硫代氨基甲酸酯-μ2S:S
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
Jie Pei;Chun-Man Jia;Qiang Lin;Wen-Bing Yuan;Qi Zhang - 通讯作者:
Qi Zhang
Terpolymerizations of CO2, Propylene Oxide and DL-Lactide Catalyzed by Zn-Fe DMC Catalysts with Quaternary Ammonium Salts
Zn-Fe DMC 季铵盐催化剂催化 CO2、环氧丙烷和 DL-丙交酯三聚
- DOI:
10.1002/slct.201904461 - 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
Ningzhang Liu;Chuanhai Gu;Mengting Chen;Junan Zhang;Wen Yang;Aihong Zhan;Kewei Zhang;Qiang Lin;Linhua Zhu - 通讯作者:
Linhua Zhu
Experimental study of the inhibition effect of CXCL12/CXCR4 in malignant pleural mesothelioma
CXCL12/CXCR4对恶性胸膜间皮瘤抑制作用的实验研究
- DOI:
- 发表时间:
2018 - 期刊:
- 影响因子:2.6
- 作者:
Jianshuang Li;Tong Li;Shuo Li;Lipeng Xie;Yi;Qiang Lin;Orli Kadoch;Hui Li;Sheng;Zhidong Xu - 通讯作者:
Zhidong Xu
Construction of bisection model of SPECT bone scan image based on VGGNet
基于VGGNet的SPECT骨扫描图像二等分模型构建
- DOI:
10.1109/aiid51893.2021.9456458 - 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
Ziwen Zheng;Liangxia Liu;Xiaoyan Chen;Qiang Lin - 通讯作者:
Qiang Lin
Development of ligustrazine hydrochloride carboxymethyl chitosan and collagen microspheres: Formulation optimization, characterization, and vitro release
盐酸川芎嗪羧甲基壳聚糖和胶原微球的开发:配方优化、表征和体外释放
- DOI:
10.1080/21655979.2016.1227584 - 发表时间:
2017-01 - 期刊:
- 影响因子:4.9
- 作者:
Qiang Lin;Qing Huo;Yingzhe Qin;Zhuo Zhao;Fengyun Tao - 通讯作者:
Fengyun Tao
Qiang Lin的其他文献
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{{ truncateString('Qiang Lin', 18)}}的其他基金
QuIC-TAQS: Multifunctional integrated quantum photonic processor for quantum interconnect
QuIC-TAQS:用于量子互连的多功能集成量子光子处理器
- 批准号:
2138174 - 财政年份:2021
- 资助金额:
$ 36万 - 项目类别:
Continuing Grant
RAISE-EQuIP: A high-speed, reconfigurable, fully integrated circuit platform for quantum photonic applications
RAISE-EQuIP:用于量子光子应用的高速、可重新配置、全集成电路平台
- 批准号:
1842691 - 财政年份:2018
- 资助金额:
$ 36万 - 项目类别:
Standard Grant
EFRI ACQUIRE: A Scalable Integrated Quantum Photonic Interconnect
EFRI ACQUIRE:可扩展的集成量子光子互连
- 批准号:
1641099 - 财政年份:2016
- 资助金额:
$ 36万 - 项目类别:
Standard Grant
Collaborative Research: Silicon Carbide Devices for Optomechanics and Photonics
合作研究:用于光机械和光子学的碳化硅器件
- 批准号:
1408517 - 财政年份:2014
- 资助金额:
$ 36万 - 项目类别:
Standard Grant
CAREER: Integrated quantum silicon photonics: Generating high-purity quantum entanglement on a silicon chip
职业:集成量子硅光子学:在硅芯片上产生高纯度量子纠缠
- 批准号:
1351697 - 财政年份:2014
- 资助金额:
$ 36万 - 项目类别:
Standard Grant
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