EAPSI: Light Mediated Synthesis of Amino Acid Analogues: A Methodology for Photochemical Asymmetric Synthesis

获得生命？由于替代的可变性和方法的局限性，S的基本构建模块是越来越大的挑战。具有生物学意义的分子往往具有特定的特殊取向和手性。获取无数分子的合成方法需要是选择性的和可变的，以便获取过多的所需分子。化学方法继续改进，但化学废物和缺乏范围和广度仍然是一个问题。本项目将重点研究利用光合成氨基酸类似物。这项研究将与福井大学的Yasuharu yoshii教授合作进行。Yoshimi教授开发了一种方法，其中光被用作合成氨基酸衍生物的试剂。然而，注意到产物的手性丧失。结合Sivagroup中发展的方法，即atroselective光反应，我们的目标是控制氨基酸类似物的手性，并获得高选择性的所需产物。获得生命？由于替代的可变性和方法的局限性，S的基本构建模块是越来越大的挑战。具有生物学意义的分子具有固有的手性。合成方法需要是选择性的和可变的，以便获得过多的所需分子。不对称合成领域不断发展。然而，化学废物和缺乏总体普遍性仍然是一个问题。本项目主要研究氨基酸类似物的光化学不对称合成。这项研究将与福井大学的Yasuharu yoshii教授合作进行。Yoshimi教授开发了一种方法，其中光被用作合成氨基酸衍生物的试剂。然而，注意到产物的手性丧失。结合Sivagroup中发展的方法，即atroselective光反应，我们的目标是控制氨基酸类似物的手性，并获得高选择性的所需产物。该奖项隶属于东亚和太平洋暑期研究所项目，由美国国家科学基金会和日本科学促进会共同资助，支持一名美国研究生进行暑期研究。

Access to life?s fundamental building blocks is an increasing challenge due to variability in substitution and limits in methodology. Molecules of biological interest often exist with specific special orientation, chirality. Methods of synthesis to access innumerable molecules needs to be selective and variable in order to access the plethora of desired molecules. Chemical methodology continues to improve however chemical waste and lack of scope and breadth continue to be an issue. This project will focus on synthesis of amino acid analogues utilizing light. This research will be conducted in collaboration with Professor Yasuharu Yoshimi of Fukui University. Prof. Yoshimi has developed a methodology wherein light is used as a reagent to synthesize amino acid derivatives. However, loss of chirality in the product was noticed. Combining the methodology developed in the Sivagroup viz., atropselective photoreactions, we aim to control chirality of the amino acid analogs and obtain the desired product with high selectivity.Access to life?s fundamental building blocks is an increasing challenge due to variability in substitution and limits in methodology. Molecules of biological interest are inherently chiral. Synthetic methods need to be selective and variable in order to access the plethora of desired molecules. The field of asymmetric synthesis continues to improve. However, chemical waste and lack of overall generality continue to be an issue. This project will focus on photochemical asymmetric synthesis of amino acid analogues. This research will be conducted in collaboration with Professor Yasuharu Yoshimi of Fukui University. Prof. Yoshimi has developed a methodology wherein light is used as a reagent to synthesize amino acid derivatives. However, loss of chirality in the product was noticed. Combining the methodology developed in the Sivagroup viz., atropselective photoreactions, we aim to control chirality of the amino acid analogs and obtain the desired product with high selectivity.This award under the East Asia and Pacific Summer Institutes program supports summer research by a U.S. graduate student and is jointly funded by NSF and the Japan Society for the Promotion of Science.