EAPSI: Light Mediated Synthesis of Amino Acid Analogues: A Methodology for Photochemical Asymmetric Synthesis

获得生命？由于替代的多样性和方法的限制，S的基本构建块是一个越来越大的挑战。具有生物意义的分子往往具有特定的特殊取向，即手性。获得无数分子的合成方法需要有选择性和多样性，才能获得过多的所需分子。化学方法在继续改进，但化学废物和缺乏广度和广度仍然是一个问题。该项目将专注于利用光合成氨基酸类似物。这项研究将与福井大学的吉井康治教授合作进行。Yoshimi教授开发了一种利用光作为试剂来合成氨基酸衍生物的方法。然而，产品中的手性丢失被注意到。结合Sivan roup发展的方法学，即反式选择性光反应，我们的目标是控制氨基酸类似物的手性，并获得高选择性的预期产品。接近生命？由于取代的多样性和方法学的限制，S的基本构建块是一个越来越大的挑战。具有生物学意义的分子本质上是手性的。为了获得过多的所需分子，合成方法需要具有选择性和可变性。不对称合成领域不断完善。然而，化学废物和缺乏总体普遍性仍然是一个问题。本项目将集中于氨基酸类似物的光化学不对称合成。这项研究将与福井大学的吉井康治教授合作进行。Yoshimi教授开发了一种利用光作为试剂来合成氨基酸衍生物的方法。然而，产品中的手性丢失被注意到。结合SIVERGROUP开发的方法学，即反式选择性光反应，我们的目标是控制氨基酸类似物的手性，并获得高选择性的预期产品。该奖项由东亚和太平洋夏季学院计划资助一名美国研究生的暑期研究，由NSF和日本科学促进会共同资助。

Access to life?s fundamental building blocks is an increasing challenge due to variability in substitution and limits in methodology. Molecules of biological interest often exist with specific special orientation, chirality. Methods of synthesis to access innumerable molecules needs to be selective and variable in order to access the plethora of desired molecules. Chemical methodology continues to improve however chemical waste and lack of scope and breadth continue to be an issue. This project will focus on synthesis of amino acid analogues utilizing light. This research will be conducted in collaboration with Professor Yasuharu Yoshimi of Fukui University. Prof. Yoshimi has developed a methodology wherein light is used as a reagent to synthesize amino acid derivatives. However, loss of chirality in the product was noticed. Combining the methodology developed in the Sivagroup viz., atropselective photoreactions, we aim to control chirality of the amino acid analogs and obtain the desired product with high selectivity.Access to life?s fundamental building blocks is an increasing challenge due to variability in substitution and limits in methodology. Molecules of biological interest are inherently chiral. Synthetic methods need to be selective and variable in order to access the plethora of desired molecules. The field of asymmetric synthesis continues to improve. However, chemical waste and lack of overall generality continue to be an issue. This project will focus on photochemical asymmetric synthesis of amino acid analogues. This research will be conducted in collaboration with Professor Yasuharu Yoshimi of Fukui University. Prof. Yoshimi has developed a methodology wherein light is used as a reagent to synthesize amino acid derivatives. However, loss of chirality in the product was noticed. Combining the methodology developed in the Sivagroup viz., atropselective photoreactions, we aim to control chirality of the amino acid analogs and obtain the desired product with high selectivity.This award under the East Asia and Pacific Summer Institutes program supports summer research by a U.S. graduate student and is jointly funded by NSF and the Japan Society for the Promotion of Science.