MRI: Acquisition of a Single Crystal X-ray Diffraction Instrument for the Creation of an X-ray Diffraction Facility at the University of Puerto Rico

MRI：采购单晶 X 射线衍射仪器，用于在波多黎各大学创建 X 射线衍射设施

• 批准号: 1626103
• 负责人: Dalice Pinero
• 金额: $ 14.99万
• 依托单位: University of Puerto Rico-Rio Piedras
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2019-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1626103&HistoricalAwards=false
• 关键词: MRI; Acquisition; Single; Crystal; ray

With this award from the Major Research Instrumentation (MRI) Program, the Chemistry Research Instrumentation (CRIF) Program as well as the Experimental Program to Stimulate Competitive Research (EPSCoR), Professor Dalice Pinero from the University Puerto Rico Rio Piedras and colleague Vilmali Lopez-Mejias have acquired a crystal X-ray diffractometer equipped with a copper source. Crystal diffraction is a powerful modern tool to determine the atomic structure of solid materials from small but relevant molecules to polymers and biological materials such as pharmaceuticals, natural products and DNA. The instrument is used in undergraduate research projects and in thesis projects of graduate students. The structural information enables researchers to understand the behavior and properties of the substances they synthesize, isolate and characterize. This information impacts the advance of basic science and technological progress from manufacturing of nanomaterials, pharmaceuticals and many other substances used in everyday life. The diffractometer is housed at the University of Puerto Rico's Molecular Sciences Research Center (UPR-MSRC), establishing a complete state-of-the-art X-ray diffraction facility that supports the research and educational efforts of multiple scientists across the metropolitan area of the island of Puerto Rico. The single crystal X-ray diffractometer is used in structural analysis of solid materials. It is aimed at enhancing research in a variety of areas including (a) synthesizing and characterizing magnetic materials for memory devices, sensors, and imaging agents, (b) designing applications and mechanistic studies for crystallization on surfaces, (c) designing a non-aldol approach towards the synthesis of polypropionate derived natural targets, (d) developing layered inorganic compounds as hosts for catalysts and drugs, (e) isolating and structurally elucidating marine natural products, (f) structurally characterizing pharmaceutical solid forms obtained in continuous crystallization processes, (g) synthesizing new transition metal complexes based on pyrene derivatives with promising applications in memory devices; and (h) synthesizing and characterizing aromatic heterocyclic compounds as potential pharmacological agents.

获得主要研究仪器（MRI）计划、化学研究仪器（CRIF）计划以及刺激竞争性研究实验计划（EPSCoR）的奖励后，波多黎各大学里约热内卢Piedras的Dalice Pinero教授和同事Vilmali Lopez-Mejias获得了一台配备铜源的晶体x射线衍射仪。晶体衍射是一种强大的现代工具，可以确定固体材料的原子结构，从小而相关的分子到聚合物和生物材料，如药物、天然产物和DNA。该仪器用于本科生的研究项目和研究生的论文项目。结构信息使研究人员能够了解他们合成、分离和表征的物质的行为和性质。这些信息影响着纳米材料、药品和许多日常生活中使用的其他物质的制造的基础科学和技术进步的进步。该衍射仪位于波多黎各大学分子科学研究中心（UPR-MSRC），建立了一个完整的最先进的x射线衍射设备，支持波多黎各岛大都市区多位科学家的研究和教育工作。单晶x射线衍射仪用于固体材料的结构分析。它的目的是加强在各个领域的研究，包括(a)合成和表征存储器件、传感器和显像剂的磁性材料，(b)设计表面结晶的应用和机理研究，(c)设计一种非醛醇方法来合成聚丙酸衍生的天然靶标，(d)开发层状无机化合物作为催化剂和药物的宿主，(e)分离和结构阐明海洋天然产物。(f)在结构上表征连续结晶过程中获得的药物固体形式，(g)合成基于芘衍生物的新的过渡金属配合物，在存储器件中有很好的应用；(h)芳香族杂环化合物的合成和表征。